1. Gene
  2. EHF - ETS homologous factor Gene

EHF - ETS homologous factor Gene

Homo sapiens

Also known as ESE3; ESEJ; ESE3B

Gene ID: 26298 | Gene type: protein coding

About EHF

Cytogenetic location: 11p13 Genomic coordinates (GRCh38): 11:34,621,093-34,663,288 (from NCBI)

This gene has 12 transcripts (splice variants), 205 orthologues and 28 paralogues. Biased expression in esophagus (RPKM 89.9), colon (RPKM 60.6) and 12 other tissues.

Summary

This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). The encoded protein acts as a transcriptional repressor and may be involved in epithelial differentiation and carcinogenesis. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

EHF Products(19)

mRNA Protein Name
NM_001206615.2 NP_001193544.1 ETS homologous factor isoform 3
NM_001206616.2 NP_001193545.1 ETS homologous factor isoform 1 precursor
NM_001378041.1 NP_001364970.1 ETS homologous factor isoform 2
NM_001378042.1 NP_001364971.1 ETS homologous factor isoform 2
NM_001378043.1 NP_001364972.1 ETS homologous factor isoform 2
NM_001378044.1 NP_001364973.1 ETS homologous factor isoform 2
NM_001378045.1 NP_001364974.1 ETS homologous factor isoform 2
NM_001378046.1 NP_001364975.1 ETS homologous factor isoform 2
NM_001378047.1 NP_001364976.1 ETS homologous factor isoform 2
NM_001378048.1 NP_001364977.1 ETS homologous factor isoform 3
NM_001378049.1 NP_001364978.1 ETS homologous factor isoform 4
NM_001378050.1 NP_001364979.1 ETS homologous factor isoform 4
NM_001378051.1 NP_001364980.1 ETS homologous factor isoform 4
NM_001378052.1 NP_001364981.1 ETS homologous factor isoform 5 precursor
NM_001378053.1 NP_001364982.1 ETS homologous factor isoform 6
NM_001378054.1 NP_001364983.1 ETS homologous factor isoform 7
NM_001378055.1 NP_001364984.1 ETS homologous factor isoform 8
NM_001378056.1 NP_001364985.1 ETS homologous factor isoform 9
NM_012153.6 NP_036285.2 ETS homologous factor isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables DNA binding IDA
IDA: Inferred from direct assay
10644770 GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
10644770 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
17027647 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
Biological Process GO Annotation Evidence Reference Source
involved in epithelial cell differentiation IEP
IEP: Inferred from expression pattern
10644770 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10644770 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EHF Protein Structure

SAM_PNT

SAM_PNT: Sterile alpha motif (SAM)/Pointed domain (38 - 114)

Ets

Ets: Ets-domain (207 - 290)

  • 0
  • 100
  • 200
  • 300 a.a.
Protein Preferred Names Protein Names

ETS homologous factor

ESE3 transcription factor

EHF Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
EHF Q9NZC4 KPRP Homo sapiens Q5T749
Anti Tag CoIP
33961781
Intra
EHF Q9NZC4 KPRP Homo sapiens Q5T749
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Allergic Urticaria
Infiltrative Basal Cell Carcinoma

Skin Infiltrating Basal Cell Carcinoma

Milk Allergy

Milk Allergic Reaction

Milk Hypersensitivity

Allergy Milk

Cow Milk Allergy

Bos Taurus Milk Allergy

Cow'S Milk Protein Sensitivity

Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Canis familiaris EHF VGNC VGNC:40249
Felis catus EHF VGNC VGNC:102879
Macaca mulatta EHF VGNC VGNC:72178
Mus musculus EHF MGD MGI:1270840
Bos taurus EHF VGNC VGNC:28375
Rattus norvegicus EHF RGD RGD:1310282