KPRP - keratinocyte proline rich protein Gene

Homo sapiens

Also known as C1orf45

Gene ID: 448834 | Gene type: protein coding

About KPRP

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:152,758,025-152,762,056 (from NCBI)

This gene has 1 transcript (splice variant), 142 orthologues and 12 paralogues. Restricted expression toward skin (RPKM 105.2).

Summary

This gene encodes a proline-rich skin protein possibly involved in keratinocyte differentiation. [provided by RefSeq, Jul 2016]

KPRP Products(1)

mRNA	Protein	Name
NM_001025231.3	NP_001020402.1	keratinocyte proline-rich protein

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	27107012	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

keratinocyte proline-rich protein

keratinocyte expressed, proline-rich protein

KPRP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KPRP	Q5T749	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	KPRP	Q5T749	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	KPRP	Q5T749	KRTAP4-2	Homo sapiens	Q9BYR5	Validated Y2H	32296183
Intra	KPRP	Q5T749	KRTAP13-3	Homo sapiens	Q3SY46	Y2H Prey Pooling	32296183
Intra	KPRP	Q5T749	KRTAP13-3	Homo sapiens	Q3SY46	Y2H Array	32296183
Intra	KPRP	Q5T749	KRTAP19-7	Homo sapiens	Q3SYF9	Y2H Array	32296183
Intra	KPRP	Q5T749	KRTAP19-7	Homo sapiens	Q3SYF9	Y2H Prey Pooling	32296183
Intra	KPRP	Q5T749	LCE3C	Homo sapiens	Q5T5A8	Y2H Prey Pooling	32296183
Intra	KPRP	Q5T749	NID2	Homo sapiens	Q8IV28	Validated Y2H	32296183
Intra	KPRP	Q5T749	DYRK1A	Homo sapiens	Q13627	Y2H Prey Pooling	32296183
Intra	KPRP	Q5T749	DYRK1A	Homo sapiens	Q13627	Y2H Array	32296183
Intra	KPRP	Q5T749	ITIH6	Homo sapiens	Q6UXX5	Y2H Array	32296183
Intra	KPRP	Q5T749	ITIH6	Homo sapiens	Q6UXX5	Validated Y2H	32296183
Intra	KPRP	Q5T749	ITIH6	Homo sapiens	Q6UXX5	Y2H Prey Pooling	32296183
Intra	KPRP	Q5T749	KRTAP1-5	Homo sapiens	Q9BYS1	Validated Y2H	32296183
Intra	KPRP	Q5T749	KRTAP1-5	Homo sapiens	Q9BYS1	Y2H Array	32296183
Intra	KPRP	Q5T749	KRTAP1-5	Homo sapiens	Q9BYS1	Y2H Prey Pooling	32296183
Intra	KPRP	Q5T749	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Prey Pooling	32296183
Intra	KPRP	Q5T749	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Array	32296183
Intra	KPRP	Q5T749	TFAP2D	Homo sapiens	Q7Z6R9	Y2H Array	32296183
Intra	KPRP	Q5T749	TFAP2D	Homo sapiens	Q7Z6R9	Validated Y2H	32296183
Intra	KPRP	Q5T749	KRTAP12-3	Homo sapiens	P60328	Y2H Array	32296183
Intra	KPRP	Q5T749	KRTAP12-3	Homo sapiens	P60328	Y2H Prey Pooling	32296183
Intra	KPRP	Q5T749	VGLL3	Homo sapiens	A8MV65-2	Y2H Array	32296183
Intra	KPRP	Q5T749	VGLL3	Homo sapiens	A8MV65-2	Y2H Prey Pooling	32296183
Intra	KPRP	Q5T749	VWC2	Homo sapiens	Q2TAL6	Y2H Prey Pooling	32296183
Intra	KPRP	Q5T749	VWC2	Homo sapiens	Q2TAL6	Y2H Array	32296183
Intra	KPRP	Q5T749	KRTAP5-3	Homo sapiens	Q6L8H2	Validated Y2H	32296183
Intra	KPRP	Q5T749	GNE	Homo sapiens	Q9Y223-2	Validated Y2H	32296183
Intra	KPRP	Q5T749	ACTMAP	Homo sapiens	Q5BKX5-3	Y2H Array	32296183
Intra	KPRP	Q5T749	ACTMAP	Homo sapiens	Q5BKX5-3	Y2H Prey Pooling	32296183
Intra	KPRP	Q5T749	FCHO1	Homo sapiens	A0A0C3SFZ9	Y2H Prey Pooling	32296183
Intra	KPRP	Q5T749	FCHO1	Homo sapiens	A0A0C3SFZ9	Y2H Array	32296183
Intra	KPRP	Q5T749	GUCD1	Homo sapiens	Q96NT3-2	Validated Y2H	32296183
Intra	KPRP	Q5T749	KRTAP5-7	Homo sapiens	Q6L8G8	Y2H Prey Pooling	32296183
Intra	KPRP	Q5T749	KRTAP5-7	Homo sapiens	Q6L8G8	Validated Y2H	32296183
Intra	KPRP	Q5T749	KRTAP5-7	Homo sapiens	Q6L8G8	Y2H Array	32296183
Intra	KPRP	Q5T749	KRTAP4-5	Homo sapiens	Q9BYR2	Validated Y2H	32296183
Intra	KPRP	Q5T749	SAXO4	Homo sapiens	Q7Z5V6-2	Validated Y2H	32296183
Intra	KPRP	Q5T749	ATG9A	Homo sapiens	Q7Z3C6-3	Validated Y2H	32296183
Intra	KPRP	Q5T749	NUFIP2	Homo sapiens	Q7Z417	Validated Y2H	32296183
Intra	KPRP	Q5T749	KRTAP6-1	Homo sapiens	Q3LI64	Y2H Prey Pooling	32296183
Intra	KPRP	Q5T749	KRTAP6-1	Homo sapiens	Q3LI64	Y2H Array	32296183
Intra	KPRP	Q5T749	KRTAP19-2	Homo sapiens	Q3LHN2	Y2H Array	32296183
Intra	KPRP	Q5T749	KRTAP19-2	Homo sapiens	Q3LHN2	Y2H Prey Pooling	32296183
Intra	KPRP	Q5T749	ESR2	Homo sapiens	Q92731-3	Validated Y2H	32296183
Intra	KPRP	Q5T749	SPRY3	Homo sapiens	O43610	Y2H Array	32296183
Intra	KPRP	Q5T749	SPRY3	Homo sapiens	O43610	Y2H Prey Pooling	32296183
Intra	KPRP	Q5T749	CES1	Homo sapiens	P23141-3	Y2H Prey Pooling	32296183
Intra	KPRP	Q5T749	CES1	Homo sapiens	P23141-3	Y2H Array	32296183
Intra	KPRP	Q5T749	KRTAP19-6	Homo sapiens	Q3LI70	Y2H Prey Pooling	32296183
Intra	KPRP	Q5T749	KRTAP19-6	Homo sapiens	Q3LI70	Y2H Array	32296183
Intra	KPRP	Q5T749	SLC15A2	Homo sapiens	Q16348	Y2H Prey Pooling	32296183
Intra	KPRP	Q5T749	SLC15A2	Homo sapiens	Q16348	Y2H Array	32296183
Intra	KPRP	Q5T749	RBP3	Homo sapiens	P10745	Y2H Array	32296183
Intra	KPRP	Q5T749	RBP3	Homo sapiens	P10745	Y2H Prey Pooling	32296183
Intra	KPRP	Q5T749	KRTAP19-1	Homo sapiens	Q8IUB9	Y2H Prey Pooling	32296183
Intra	KPRP	Q5T749	KRTAP19-1	Homo sapiens	Q8IUB9	Validated Y2H	32296183
Intra	KPRP	Q5T749	KRTAP19-1	Homo sapiens	Q8IUB9	Y2H Array	32296183
Intra	KPRP	Q5T749	CNFN	Homo sapiens	Q9BYD5	Y2H Prey Pooling	32296183
Intra	KPRP	Q5T749	CNFN	Homo sapiens	Q9BYD5	Validated Y2H	32296183
Intra	KPRP	Q5T749	CNFN	Homo sapiens	Q9BYD5	Y2H Array	32296183
Intra	KPRP	Q5T749	LIMS1	Homo sapiens	P48059-3	Y2H Prey Pooling	32296183
Intra	KPRP	Q5T749	LIMS1	Homo sapiens	P48059-3	Y2H Array	32296183
Intra	KPRP	Q5T749	FAM72B	Homo sapiens	Q86X60-2	Y2H Prey Pooling	32296183
Intra	KPRP	Q5T749	FAM72B	Homo sapiens	Q86X60-2	Validated Y2H	32296183
Intra	KPRP	Q5T749	FAM72B	Homo sapiens	Q86X60-2	Y2H Array	32296183
Intra	KPRP	Q5T749	NR4A3	Homo sapiens	Q92570	Validated Y2H	32296183
Intra	KPRP	Q5T749	NR4A3	Homo sapiens	Q92570	Y2H Array	32296183
Intra	KPRP	Q5T749	NR4A3	Homo sapiens	Q92570	Y2H Prey Pooling	32296183
Intra	KPRP	Q5T749	UBASH3B	Homo sapiens	Q8TF42	Validated Y2H	32296183
Intra	KPRP	Q5T749	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	KPRP	Q5T749	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	KPRP	Q5T749	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	KPRP	Q5T749	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	KPRP	Q5T749	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	KPRP	Q5T749	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Array	32296183
Intra	KPRP	Q5T749	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Prey Pooling	32296183
Intra	KPRP	Q5T749	RNF38	Homo sapiens	Q9H0F5	Validated Y2H	32296183
Intra	KPRP	Q5T749	FBXO17	Homo sapiens	Q96EF6	Validated Y2H	32296183
Intra	KPRP	Q5T749	PPIL1	Homo sapiens	Q9Y3C6	Validated Y2H	32296183
Intra	KPRP	Q5T749	SH3KBP1	Homo sapiens	Q96B97	Validated Y2H	32296183
Intra	KPRP	Q5T749	AKAP8L	Homo sapiens	Q9ULX6	Validated Y2H	32296183
Intra	KPRP	Q5T749	AKAP8L	Homo sapiens	Q9ULX6	Y2H Prey Pooling	32296183
Intra	KPRP	Q5T749	AKAP8L	Homo sapiens	Q9ULX6	Y2H Array	32296183
Intra	KPRP	Q5T749	GLRX3	Homo sapiens	O76003	Y2H Prey Pooling	32296183
Intra	KPRP	Q5T749	GLRX3	Homo sapiens	O76003	Y2H Array	32296183
Intra	KPRP	Q5T749	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	KPRP	Q5T749	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	KPRP	Q5T749	HSD3B7	Homo sapiens	Q9H2F3	Validated Y2H	32296183
Intra	KPRP	Q5T749	TRIM42	Homo sapiens	Q8IWZ5	Y2H Prey Pooling	32296183
Intra	KPRP	Q5T749	TRIM42	Homo sapiens	Q8IWZ5	Validated Y2H	32296183
Intra	KPRP	Q5T749	TRIM42	Homo sapiens	Q8IWZ5	Y2H Array	32296183
Intra	KPRP	Q5T749	HEXIM2	Homo sapiens	Q96MH2	Validated Y2H	32296183
Intra	KPRP	Q5T749	ZNF587	Homo sapiens	Q96SQ5	Validated Y2H	32296183
Intra	KPRP	Q5T749	LCE3D	Homo sapiens	Q9BYE3	Validated Y2H	32296183
Intra	KPRP	Q5T749	SPRED2	Homo sapiens	Q7Z698	Validated Y2H	32296183
Intra	KPRP	Q5T749	PLA2G10	Homo sapiens	O15496	Y2H Prey Pooling	32296183
Intra	KPRP	Q5T749	PLA2G10	Homo sapiens	O15496	Y2H Array	32296183
Intra	KPRP	Q5T749	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	KPRP	Q5T749	GRAP2	Homo sapiens	O75791	Y2H Prey Pooling	32296183
Intra	KPRP	Q5T749	GRAP2	Homo sapiens	O75791	Y2H Array	32296183
Intra	KPRP	Q5T749	OTX1	Homo sapiens	P32242	Y2H Array	32296183
Intra	KPRP	Q5T749	OTX1	Homo sapiens	P32242	Y2H Prey Pooling	32296183
Intra	KPRP	Q5T749	HOXA1	Homo sapiens	P49639	Y2H Prey Pooling	32296183
Intra	KPRP	Q5T749	HOXA1	Homo sapiens	P49639	Y2H Array	32296183
Intra	KPRP	Q5T749	CNNM3	Homo sapiens	Q8NE01	Validated Y2H	32296183
Intra	KPRP	Q5T749	TRIP6	Homo sapiens	Q15654	Y2H Prey Pooling	32296183
Intra	KPRP	Q5T749	TRIP6	Homo sapiens	Q15654	Y2H Array	32296183
Intra	KPRP	Q5T749	TRIP6	Homo sapiens	Q15654	Validated Y2H	32296183
Intra	KPRP	Q5T749	NTN4	Homo sapiens	Q9HB63	Validated Y2H	32296183
Intra	KPRP	Q5T749	CATSPER1	Homo sapiens	Q8NEC5	Validated Y2H	32296183
Intra	KPRP	Q5T749	TEKT4	Homo sapiens	Q8WW24	Validated Y2H	32296183
Intra	KPRP	Q5T749	KRTAP3-2	Homo sapiens	Q9BYR7	Validated Y2H	32296183
Intra	KPRP	Q5T749	KRTAP3-2	Homo sapiens	Q9BYR7	Y2H Prey Pooling	32296183
Intra	KPRP	Q5T749	KRTAP3-2	Homo sapiens	Q9BYR7	Y2H Array	32296183
Intra	KPRP	Q5T749	PLSCR4	Homo sapiens	Q9NRQ2	Validated Y2H	32296183
Intra	KPRP	Q5T749	MAPKBP1	Homo sapiens	O60336	Y2H Prey Pooling	32296183
Intra	KPRP	Q5T749	TNS2	Homo sapiens	Q63HR2	Validated Y2H	32296183
Intra	KPRP	Q5T749	DMRT3	Homo sapiens	Q9NQL9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Pancreatic Squamous Cell Carcinoma

Autosomal Recessive Congenital Ichthyosis

Lamellar Ichthyosis	Congenital Ichthyosiform Erythroderma
Li	Congenital Nonbullous Ichthyosiform Erythroderma
Arci	Congenital Lamellar Ichthyosis
Nonbullous Congenital Ichthyosiform Erythroderma	Cie
Congenital Non-Bullous Ichthyosiform Erythroderma	Erythrodermic Ichthyosis
Nbcie	Ncie
Non-Bullous Congenital Ichthyosiform Erythroderma	Collodion Baby
Ichthyosis, Lamellar	Non Bullous Congenital Ichthyosiform Erythroderma
Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form	Ichthyosiform Erythroderma, Congenital, Nonbullous, 1
Collodion Baby Syndrome	Ichthyoses, Lamellar
Nbie	Nonbullous Ichthyosiform Erythroderma
Classic Lamellar Ichthyosis	Ichthyosiform Erythroderma Nonbullous Congenital
Ichthyosiform Erythroderma Congenital	Ichthyosis, Congenital, Autosomal Recessive
Ichthyosiform Erythroderma, Congenital	Collodion Fetus
Non-Bullous Ichthyosiform Erythroderma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07423	KPRP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	KPRP	RGD	RGD:1303244
Bos taurus	KPRP	VGNC	VGNC:30708
Macaca mulatta	KPRP	VGNC	VGNC:106400
Mus musculus	KPRP	MGD	MGI:1920981

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