GAPDHS - glyceraldehyde-3-phosphate dehydrogenase, spermatogenic Gene

Homo sapiens

Also known as GAPD2; GAPDS; HSD-35; GAPDH-2; HEL-S-278

Gene ID: 26330 | Gene type: protein coding

About GAPDHS

Cytogenetic location: 19q13.12 Genomic coordinates (GRCh38): 19:35,533,456-35,545,319 (from NCBI)

This gene has 3 transcripts (splice variants), 189 orthologues and 1 paralogue. Biased expression in testis (RPKM 87.7) and thyroid (RPKM 2.9).

Summary

This gene encodes a protein belonging to the glyceraldehyde-3-phosphate dehydrogenase family of Enzymes that play an important role in carbohydrate metabolism. Like its somatic cell counterpart, this sperm-specific Enzyme functions in a nicotinamide adenine dinucleotide-dependent manner to remove hydrogen and add phosphate to glyceraldehyde 3-phosphate to form 1,3-diphosphoglycerate. During spermiogenesis, this Enzyme may play an important role in regulating the switch between different energy-producing pathways, and it is required for sperm motility and male fertility. [provided by RefSeq, Jul 2008]

GAPDHS Products(1)

mRNA	Protein	Name
NM_014364.5	NP_055179.1	glyceraldehyde-3-phosphate dehydrogenase, testis-specific

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16820410	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GAPDHS Protein Structure

Gp_dh_N

Gp_dh_C

0
100
200
300
408 a.a.

Protein Preferred Names

Protein Names

glyceraldehyde-3-phosphate dehydrogenase, testis-specific

epididymis secretory protein Li 278

Related Diseases

Diseases

Alias

Ovarian Dysgenesis 2

Premature Ovarian Failure 4	ODG2
Ovarian Dysgenesis, Hypergonadotropic, X-Linked	Ovarian Failure, Hypergonadotropic, Due To Ovarian Dysgenesis
Ovarian Failure Hypergonadotropic Due To Ovarian Dysgenesis	X-Linked Hypergonadotropic Ovarian Dysgenesis
POF4	Dysgenesis, Ovarian, Type 2

Retinitis Pigmentosa 38

RP38	Rod-Cone Dystrophy, Childhood-Onset
Retinitis Pigmentosa, Type 38

Corneal Dystrophy And Perceptive Deafness

Corneal Dystrophy-Perceptive Deafness Syndrome	CDPD
Harboyan Syndrome	Cdpd1
Corneal Dystrophy And Sensorineural Deafness	Corneal Endothelial Dystrophy And Perceptive Deafness
Corneal Dystrophy With Progressive Deafness	Congenital Corneal Dystrophy, Progressive Sensorineural Deafness
Corneal Dystrophy With Progressive Hearing Loss	Corneal Dystrophy-Perceptive Hearing Loss Syndrome
Dystrophy, Corneal, Endothelial, And Perceptive Deafness

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-16361A	Omigapil maleate	Inhibitor	99.43%	Phase 2
HY-147280	Misetionamide	Inducer	99.49%	Phase 1

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-123962	G6PD activator AG1	Activator	99.54%	Unkown
HY-112758	DLin-KC2-DMA		99.88%	Unkown
HY-D0849	Sodium iodoacetate	Inhibitor	99.91%	Unkown
HY-120838	Heptelidic acid	Inhibitor	97.50%	Unkown
HY-132126	SPHINX	Inhibitor	99.87%	Unkown
HY-157395	malonyl-NAC		/	Unkown
HY-123668	KM05382		/	Unkown
HY-131921	DL-Glyceraldehyde 3-phosphate diethyl acetal barium		/	Unkown
HY-161668	Ru-Poma		/	Unkown
HY-N3247	Monomethyl kolavate	Inhibitor	/	Unkown
HY-RS03616	DDIT4L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS05273	GAPDH Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS05274	GAPDHS Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS16258	Lipt1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	GAPDHS	VGNC	VGNC:29248
Macaca mulatta	GAPDHS	VGNC	VGNC:72778
Mus musculus	GAPDHS	MGD	MGI:95653
Rattus norvegicus	GAPDHS	RGD	RGD:620150
Felis catus	GAPDHS	VGNC	VGNC:62460
Canis familiaris	GAPDHS	VGNC	VGNC:41109

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