2. Gene
  3. GAPDHS - glyceraldehyde-3-phosphate dehydrogenase, spermatogenic Gene

GAPDHS - glyceraldehyde-3-phosphate dehydrogenase, spermatogenic Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GAPD2; GAPDS; HSD-35; GAPDH-2; HEL-S-278

Gene ID: 26330 | Gene type: protein coding

About GAPDHS

Cytogenetic location: 19q13.12 Genomic coordinates (GRCh38): 19:35,533,456-35,545,319 (from NCBI)

This gene has 3 transcripts (splice variants), 189 orthologues and 1 paralogue. Biased expression in testis (RPKM 87.7) and thyroid (RPKM 2.9).

Summary

This gene encodes a protein belonging to the glyceraldehyde-3-phosphate dehydrogenase family of Enzymes that play an important role in carbohydrate metabolism. Like its somatic cell counterpart, this sperm-specific Enzyme functions in a nicotinamide adenine dinucleotide-dependent manner to remove hydrogen and add phosphate to glyceraldehyde 3-phosphate to form 1,3-diphosphoglycerate. During spermiogenesis, this Enzyme may play an important role in regulating the switch between different energy-producing pathways, and it is required for sperm motility and male fertility. [provided by RefSeq, Jul 2008]

GAPDHS Products(1)

mRNA Protein Name
NM_014364.5 NP_055179.1 glyceraldehyde-3-phosphate dehydrogenase, testis-specific
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16820410 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GAPDHS Protein Structure

Gp_dh_N

Gp_dh_N: Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain (77 - 224)

Gp_dh_C

Gp_dh_C: Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain (229 - 386)

  • 0
  • 100
  • 200
  • 300
  • 408 a.a.
Protein Preferred Names Protein Names

glyceraldehyde-3-phosphate dehydrogenase, testis-specific

epididymis secretory protein Li 278

GAPDHS Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
GAPDHS O14556 ZMYND19 Homo sapiens Q96E35
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Ovarian Dysgenesis 2

Premature Ovarian Failure 4

ODG2

Ovarian Dysgenesis, Hypergonadotropic, X-Linked

Ovarian Failure, Hypergonadotropic, Due To Ovarian Dysgenesis

Ovarian Failure Hypergonadotropic Due To Ovarian Dysgenesis

X-Linked Hypergonadotropic Ovarian Dysgenesis

POF4

Dysgenesis, Ovarian, Type 2
Retinitis Pigmentosa 38

RP38

Rod-Cone Dystrophy, Childhood-Onset

Retinitis Pigmentosa, Type 38
Corneal Dystrophy And Perceptive Deafness

Corneal Dystrophy-Perceptive Deafness Syndrome

CDPD

Harboyan Syndrome

Cdpd1

Corneal Dystrophy And Sensorineural Deafness

Corneal Endothelial Dystrophy And Perceptive Deafness

Corneal Dystrophy With Progressive Deafness

Congenital Corneal Dystrophy, Progressive Sensorineural Deafness

Corneal Dystrophy With Progressive Hearing Loss

Corneal Dystrophy-Perceptive Hearing Loss Syndrome

Dystrophy, Corneal, Endothelial, And Perceptive Deafness
Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-16361A Omigapil maleate Inhibitor 99.43% Phase 2
HY-147280 Misetionamide Inducer 99.49% Phase 1
Pre-clinical Phase
Bioactive Molecules (19)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-123962 G6PD activator AG1 Activator 99.54% Unkown
HY-112758 DLin-KC2-DMA 99.88% Unkown
HY-D0849 Sodium iodoacetate Inhibitor 99.91% Unkown
HY-120838 Heptelidic acid Inhibitor 97.50% Unkown
HY-157395 malonyl-NAC / Unkown
HY-132126 SPHINX Inhibitor 99.87% Unkown
HY-RS05273 GAPDH Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS16270 TANGO1-S Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS16277 SLAMF4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-123668 KM05382 Inhibitor / Unkown
HY-131921 DL-Glyceraldehyde 3-phosphate diethyl acetal barium / Unkown
HY-161668 Ru-Poma / Unkown
HY-N3247 Monomethyl kolavate Inhibitor / Unkown
HY-RS03616 DDIT4L Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS05274 GAPDHS Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS16258 Lipt1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS16274 Human CDC27P10 Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS16276 KRT19 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS16278 IL2RB Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus GAPDHS VGNC VGNC:29248
Macaca mulatta GAPDHS VGNC VGNC:72778
Mus musculus GAPDHS MGD MGI:95653
Rattus norvegicus GAPDHS RGD RGD:620150
Felis catus GAPDHS VGNC VGNC:62460
Canis familiaris GAPDHS VGNC VGNC:41109