2. Gene
  3. Mapk8 - mitogen-activated protein kinase 8 Gene

Mapk8 - mitogen-activated protein kinase 8 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as JNK; JNK1; Prkm8; SAPK1

Gene ID: 26419 | Gene type: protein coding

About Mapk8

Chromosome 14: 33,099,855-33,169,115 reverse strand.GRCm39:CM001007.3

This gene has 11 transcripts (splice variants), 291 orthologues, 19 paralogues and is associated with 38 phenotypes. Broad expression in CNS E18 (RPKM 19.1), CNS E14 (RPKM 18.4) and 26 other tissues.

Summary

Enables JUN kinase activity and protein serine/threonine/tyrosine kinase activity. Involved in several processes, including JNK cascade; generation of neurons; and positive regulation of cellular protein metabolic process. Acts upstream of or within several processes, including cellular response to nitric oxide; positive regulation of determination of dorsal identity; and protein phosphorylation. Located in several cellular components, including basal dendrite; mitochondrion; and podosome. Is expressed in several structures, including central nervous system; genitourinary system; oral region epithelium; sensory organ; and skin. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm; chronic mucocutaneous candidiasis; colorectal adenoma; rectal benign neoplasm; and type 2 diabetes mellitus. Orthologous to human MAPK8 (mitogen-activated protein kinase 8). [provided by Alliance of Genome Resources, Apr 2022]

Mapk8 Products(4)

mRNA Protein Name
NM_001310454.1 NP_001297383.1 mitogen-activated protein kinase 8 isoform 3
NM_001310452.1 NP_001297381.1 mitogen-activated protein kinase 8 isoform 2
NM_001310453.1 NP_001297382.1 mitogen-activated protein kinase 8 isoform 4
NM_016700.4 NP_057909.1 mitogen-activated protein kinase 8 isoform 1

Mapk8 Protein Structure

STKc_JNK

STKc_JNK: cd07850 (24 - 359)

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  • 427 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase 8

JNK1 beta1 protein kinase

MAP kinase 8

MAPK 8

c-Jun N-terminal kinase 1

protein kinase mitogen-activated 8

stress-activated protein kinase JNK1

Related Agents

Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-148063 DB0614 98.80% Unkown
HY-128448 Carmoisine ≥98.0% Unkown
HY-148061 DB1113 99.28% Unkown
HY-RS08123 Mapk8 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS08121 MAPK8 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS08122 Mapk8 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS08124 MAPK8IP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS08125 MAPK8IP2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS08126 MAPK8IP3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mapk8 NCBI NCBI:5599