Mapk8 - mitogen-activated protein kinase 8 Gene

Mus musculus

Also known as JNK; JNK1; Prkm8; SAPK1

Gene ID: 26419 | Gene type: protein coding

About Mapk8

Chromosome 14: 33,099,855-33,169,115 reverse strand.GRCm39:CM001007.3

This gene has 11 transcripts (splice variants), 291 orthologues, 19 paralogues and is associated with 38 phenotypes. Broad expression in CNS E18 (RPKM 19.1), CNS E14 (RPKM 18.4) and 26 other tissues.

Summary

Enables JUN kinase activity and protein serine/threonine/tyrosine kinase activity. Involved in several processes, including JNK cascade; generation of neurons; and positive regulation of cellular protein metabolic process. Acts upstream of or within several processes, including cellular response to nitric oxide; positive regulation of determination of dorsal identity; and protein phosphorylation. Located in several cellular components, including basal dendrite; mitochondrion; and podosome. Is expressed in several structures, including central nervous system; genitourinary system; oral region epithelium; sensory organ; and skin. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm; chronic mucocutaneous candidiasis; colorectal adenoma; rectal benign neoplasm; and type 2 diabetes mellitus. Orthologous to human MAPK8 (mitogen-activated protein kinase 8). [provided by Alliance of Genome Resources, Apr 2022]

Mapk8 Products(4)

mRNA	Protein	Name
NM_001310454.1	NP_001297383.1	mitogen-activated protein kinase 8 isoform 3
NM_001310452.1	NP_001297381.1	mitogen-activated protein kinase 8 isoform 2
NM_001310453.1	NP_001297382.1	mitogen-activated protein kinase 8 isoform 4
NM_016700.4	NP_057909.1	mitogen-activated protein kinase 8 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables JUN kinase activity	IDA IDA: Inferred from direct assay	10811224	MGI
enables kinase activity	IDA IDA: Inferred from direct assay	12808090	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10471813	MGI
enables protein kinase activity	IDA IDA: Inferred from direct assay	24889144	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	24127566	MGI
enables protein serine/threonine/tyrosine kinase activity	IMP IMP: Inferred from mutant phenotype	29153991	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in JNK cascade	IDA IDA: Inferred from direct assay	10811224	MGI
acts upstream of or within JUN phosphorylation	IMP IMP: Inferred from mutant phenotype	14967141	MGI
acts upstream of apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	16458303	MGI
acts upstream of or within cellular response to biotic stimulus	IMP IMP: Inferred from mutant phenotype	23262141	MGI
acts upstream of or within cellular response to hydrogen peroxide	IDA IDA: Inferred from direct assay	20808772	MGI
acts upstream of or within cellular response to nitric oxide	IMP IMP: Inferred from mutant phenotype	18007661	MGI
involved in dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	16000625	MGI
involved in energy homeostasis	IDA IDA: Inferred from direct assay	36977414	MGI
involved in integrin-mediated signaling pathway	IDA IDA: Inferred from direct assay	36812915	MGI
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	17284179	MGI
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	17284179	MGI
involved in neuron migration	IMP IMP: Inferred from mutant phenotype	21297631	MGI
acts upstream of or within ossification	IMP IMP: Inferred from mutant phenotype	15820682	MGI
acts upstream of or within peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	24889144	MGI
acts upstream of or within peptidyl-threonine phosphorylation	IMP IMP: Inferred from mutant phenotype	14967141	MGI
involved in positive regulation of NLRP3 inflammasome complex assembly	IDA IDA: Inferred from direct assay	28943315	MGI
acts upstream of or within positive regulation of apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	16458303	MGI
acts upstream of or within positive regulation of determination of dorsal identity	IDA IDA: Inferred from direct assay	18316368	MGI
acts upstream of or within positive regulation of podosome assembly	IMP IMP: Inferred from mutant phenotype	24127566	MGI
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	29153991	MGI
involved in positive regulation of protein ubiquitination	IMP IMP: Inferred from mutant phenotype	29153991	MGI
acts upstream of or within programmed necrotic cell death	IMP IMP: Inferred from mutant phenotype	18007661	MGI
acts upstream of or within protein localization to tricellular tight junction	IMP IMP: Inferred from mutant phenotype	24889144	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	15767678	MGI
involved in protein phosphorylation	IMP IMP: Inferred from mutant phenotype	22441692	MGI
involved in regulation of circadian rhythm	IMP IMP: Inferred from mutant phenotype	22441692	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	19289495	MGI
acts upstream of or within response to cadmium ion	IGI IGI: Inferred from genetic interaction	16458303	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	17284179	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	17284179	MGI
located in axon	IMP IMP: Inferred from mutant phenotype	22683681	MGI
located in basal dendrite	IMP IMP: Inferred from mutant phenotype	22683681	MGI
is active in cytoplasm	IDA IDA: Inferred from direct assay	29078390	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	15030387	MGI
located in cytoplasm	IMP IMP: Inferred from mutant phenotype	29153991	MGI
located in cytosol	IDA IDA: Inferred from direct assay	11884367	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	11884367	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	29078390	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15030387	MGI
located in podosome	IDA IDA: Inferred from direct assay	24127566	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mapk8 Protein Structure

STKc_JNK

0
100
200
300
400
427 a.a.

Protein Preferred Names

Protein Names

mitogen-activated protein kinase 8

JNK1 beta1 protein kinase	MAP kinase 8
MAPK 8	c-Jun N-terminal kinase 1
protein kinase mitogen-activated 8	stress-activated protein kinase JNK1

Mapk8 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Mapk8	Q91Y86	Jun	Mus musculus	P05627	Protein Kinase Assay	17255944

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-128448	Carmoisine		≥98.0%	Unkown
HY-148063	DB0614		98.80%	Unkown
HY-148061	DB1113		99.28%	Unkown
HY-RS08123	Mapk8 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08121	MAPK8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08122	Mapk8 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08124	MAPK8IP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08125	MAPK8IP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08126	MAPK8IP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mapk8	NCBI	NCBI:5599

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