GCNT1 - glucosaminyl (N-acetyl) transferase 1 Gene

Homo sapiens

Also known as G6NT; C2GNT; C2GNT1; NACGT2; NAGCT2; C2GNT-L; C2GlcNAcT

Gene ID: 2650 | Gene type: protein coding

About GCNT1

Cytogenetic location: 9q21.13 Genomic coordinates (GRCh38): 9:76,441,666-76,507,416 (from NCBI)

This gene has 6 transcripts (splice variants), 150 orthologues and 8 paralogues. Biased expression in duodenum (RPKM 20.0), stomach (RPKM 13.9) and 13 other tissues.

Summary

This gene is a member of the beta-1,6-N-acetylglucosaminyltransferase gene family. It is essential to the formation of Gal beta 1-3(GlcNAc beta 1-6)GalNAc structures and the core 2 O-glycan branch. The gene coding this Enzyme was originally mapped to 9q21, but was later localized to 9q13. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

GCNT1 Products(9)

mRNA	Protein	Name
NM_001097633.2	NP_001091102.1	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
NM_001097634.1	NP_001091103.1	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
NM_001097635.2	NP_001091104.1	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
NM_001097636.2	NP_001091105.1	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
NM_001407181.1	NP_001394110.1	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
NM_001407182.1	NP_001394111.1	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
NM_001407183.1	NP_001394112.1	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
NM_001407184.1	NP_001394113.1	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
NM_001490.5	NP_001481.2	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23027862	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in O-glycan processing, core 2	IDA IDA: Inferred from direct assay	1329093	GOA
involved in cell adhesion molecule production	IMP IMP: Inferred from mutant phenotype	23027862	GOA
involved in glycoprotein biosynthetic process	IMP IMP: Inferred from mutant phenotype	23027862	GOA
involved in leukocyte tethering or rolling	IMP IMP: Inferred from mutant phenotype	23027862	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi cisterna	IDA IDA: Inferred from direct assay	23027862	GOA
located in trans-Golgi network	IDA IDA: Inferred from direct assay	23027862	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GCNT1 Protein Structure

Branch

0
100
200
300
400
428 a.a.

Protein Preferred Names

Protein Names

beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

beta-1,6-N-acetylglucosaminyltransferase

GCNT1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GCNT1	Q02742	GOLPH3	Homo sapiens	Q9H4A6	Y2H	23027862
Intra	GCNT1	Q02742	GOLPH3	Homo sapiens	Q9H4A6	Pull Down	23027862

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05339	GCNT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GCNT1	RGD	RGD:621370
Canis familiaris	GCNT1	VGNC	VGNC:54843
Mus musculus	GCNT1	MGD	MGI:95676
Bos taurus	GCNT1	VGNC	VGNC:56968

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