DAZAP1 - DAZ associated protein 1 Gene

Homo sapiens

Gene ID: 26528 | Gene type: protein coding

About DAZAP1

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:1,407,586-1,435,684 (from NCBI)

This gene has 11 transcripts (splice variants), 201 orthologues and 36 paralogues. Ubiquitous expression in testis (RPKM 19.6), appendix (RPKM 11.8) and 25 other tissues.

Summary

In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ (deleted in azoospermia) gene cluster maps to the AZFc region of the Y chromosome and is deleted in many azoospermic and severely oligospermic men. It is thought that the DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL also involved in germ cell development and gametogenesis. This gene encodes a RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL. Two isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]

DAZAP1 Products(5)

mRNA	Protein	Name
NM_001352033.2	NP_001338962.1	DAZ-associated protein 1 isoform c
NM_001352034.2	NP_001338963.1	DAZ-associated protein 1 isoform d
NM_001352035.2	NP_001338964.1	DAZ-associated protein 1 isoform e
NM_018959.4	NP_061832.2	DAZ-associated protein 1 isoform b
NM_170711.3	NP_733829.1	DAZ-associated protein 1 isoform a

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables poly(G) binding	IMP IMP: Inferred from mutant phenotype	10857750	GOA
enables poly(U) RNA binding	IMP IMP: Inferred from mutant phenotype	10857750	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10857750	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of protein-containing complex	IDA IDA: Inferred from direct assay	10857750	GOA
part of ribonucleoprotein complex	IMP IMP: Inferred from mutant phenotype	10857750	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DAZAP1 Protein Structure

RRM_1

0
100
200
300
407 a.a.

Protein Preferred Names

Protein Names

DAZ-associated protein 1

deleted in azoospermia-associated protein 1

DAZAP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DAZAP1	Q96EP5	DAZ1	Homo sapiens	Q9NQZ3	Pull Down	10857750

Cross: Cross-species interaction Intra: Intraspecies interaction

DAZAP1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82901	DAZAP1 Antibody (YA2646)	WB, IP	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Infertility

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03540	DAZAP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DAZAP1	VGNC	VGNC:71738
Rattus norvegicus	DAZAP1	RGD	RGD:1305280
Bos taurus	DAZAP1	VGNC	VGNC:27885
Canis familiaris	DAZAP1	VGNC	VGNC:39778
Mus musculus	DAZAP1	MGD	MGI:1917498
Felis catus	DAZAP1	VGNC	VGNC:61344

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