1. Gene
  2. GDI2 - GDP dissociation inhibitor 2 Gene

GDI2 - GDP dissociation inhibitor 2 Gene

Homo sapiens

Also known as RABGDIB; HEL-S-46e

Gene ID: 2665 | Gene type: protein coding

About GDI2

Cytogenetic location: 10p15.1 Genomic coordinates (GRCh38): 10:5,765,223-5,813,434 (from NCBI)

This gene has 9 transcripts (splice variants), 252 orthologues and 3 paralogues. Ubiquitous expression in lymph node (RPKM 104.1), appendix (RPKM 84.4) and 25 other tissues.

Summary

GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the Ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

GDI2 Products(2)

mRNA Protein Name
NM_001115156.2 NP_001108628.1 rab GDP dissociation inhibitor beta isoform 2
NM_001494.4 NP_001485.2 rab GDP dissociation inhibitor beta isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
11809807 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of cilium assembly IMP
IMP: Inferred from mutant phenotype
25860027 GOA
involved in negative regulation of protein localization to cilium IMP
IMP: Inferred from mutant phenotype
25860027 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GDI2 Protein Structure

GDI

GDI: GDP dissociation inhibitor (1 - 437)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 445 a.a.
Protein Preferred Names Protein Names

rab GDP dissociation inhibitor beta

GDI-2

GDI2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
GDI2 P50395 RAB1A Homo sapiens P62820-1 20176951
Cross
GDI2 P50395 Dzip1 Mus musculus Q8BMD2-1 25860027
Cross
GDI2 P50395 Dzip1 Mus musculus Q8BMD2-1 25860027
Intra
GDI2 P50395 RAB24 Homo sapiens Q969Q5 35271311
Cross
GDI2 P50395 Rab8a Mus musculus P55258 25860027
Cross
GDI2 P50395 Dzip1 Mus musculus Q8BMD2 25860027
Intra
GDI2 P50395 RAB4A Homo sapiens P20338 35271311
Intra
GDI2 P50395 RAB4A Homo sapiens P20338 19570034
Cross
GDI2 P50395 Rab10 Mus musculus P61027 19570034
Cross
GDI2 P50395 Rab10 Mus musculus P61027 19570034
Cross
GDI2 P50395 Rab10 Mus musculus P61027 19570034
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GDI2 Proteins

Cat. No. Product Name Accession Purity
HY-P71737 GDI2 Protein, Human (P.pastoris, His) P50395 (M1-D445) ≥95%

Orthologs Information

Species Symbol Source ID
Mus musculus GDI2 MGD MGI:99845
Rattus norvegicus GDI2 RGD RGD:61802
Bos taurus GDI2 VGNC VGNC:29308
Canis familiaris GDI2 VGNC VGNC:41165
Felis catus GDI2 VGNC VGNC:62507
Macaca mulatta GDI2 VGNC VGNC:72911
Others GDI2 NCBI