VPS41 - VPS41 subunit of HOPS complex Gene

Homo sapiens

Also known as HVPS41; HVSP41; SCAR29; hVps41p

Gene ID: 27072 | Gene type: protein coding

About VPS41

Cytogenetic location: 7p14.1 Genomic coordinates (GRCh38): 7:38,722,974-38,909,191 (from NCBI)

This gene has 14 transcripts (splice variants), 209 orthologues and is associated with 2 phenotypes. Ubiquitous expression in brain (RPKM 18.7), gall bladder (RPKM 13.0) and 25 other tissues.

Summary

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human ortholog of yeast Vps41 protein which is also conserved in Drosophila, tomato, and Arabidopsis. Expression studies in yeast and human indicate that this protein may be involved in the formation and fusion of transport vesicles from the Golgi. Several transcript variants encoding different isoforms have been described for this gene, however, the full-length nature of not all is known. [provided by RefSeq, Jul 2008]

VPS41 Products(2)

mRNA	Protein	Name
NM_014396.4	NP_055211.2	vacuolar protein sorting-associated protein 41 homolog isoform 1
NM_080631.4	NP_542198.2	vacuolar protein sorting-associated protein 41 homolog isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	24210660	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19109425	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Golgi vesicle transport	IMP IMP: Inferred from mutant phenotype	11412045	GOA
involved in endosomal vesicle fusion	IMP IMP: Inferred from mutant phenotype	23167963	GOA
involved in endosome to lysosome transport	IMP IMP: Inferred from mutant phenotype	25783203	GOA
involved in late endosome to lysosome transport	IMP IMP: Inferred from mutant phenotype	23167963	GOA
involved in vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	33851776	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of AP-3 adaptor complex	IDA IDA: Inferred from direct assay	21411634	GOA
located in Golgi-associated vesicle	IMP IMP: Inferred from mutant phenotype	11412045	GOA
part of HOPS complex	IDA IDA: Inferred from direct assay	19109425	GOA
part of HOPS complex	IMP IMP: Inferred from mutant phenotype	33851776	GOA
part of clathrin complex	IDA IDA: Inferred from direct assay	21411634	GOA
located in clathrin-coated vesicle	IDA IDA: Inferred from direct assay	21411634	GOA
located in cytosol	IDA IDA: Inferred from direct assay	11412045	GOA
located in endosome membrane	IDA IDA: Inferred from direct assay	21411634	GOA
located in late endosome	IDA IDA: Inferred from direct assay	33422265	GOA
located in late endosome membrane	IDA IDA: Inferred from direct assay	23167963	GOA
part of lysosomal HOPS complex	IDA IDA: Inferred from direct assay	21802320	GOA
located in lysosomal membrane	IDA IDA: Inferred from direct assay	23167963	GOA
located in lysosome	IDA IDA: Inferred from direct assay	21802320	GOA
located in membrane	IDA IDA: Inferred from direct assay	11412045	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VPS41 Protein Structure

Clathrin

0
200
400
600
800
854 a.a.

Protein Preferred Names

Protein Names

vacuolar protein sorting-associated protein 41 homolog

S53

VPS41 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	VPS41	P49754	VPS18	Homo sapiens	Q9P253	Anti Tag CoIP	33961781
Intra	VPS41	P49754	VPS18	Homo sapiens	Q9P253	Anti Tag CoIP	35271311
Intra	VPS41	P49754	VPS11	Homo sapiens	Q9H270	Anti Tag CoIP	33961781
Intra	VPS41	P49754	VPS11	Homo sapiens	Q9H270	Anti Tag CoIP	25500191
Intra	VPS41	P49754	PLEKHM1	Homo sapiens	Q9Y4G2	Anti Tag CoIP	25500191
Intra	VPS41	P49754	STX17	Homo sapiens	P56962	Anti Tag CoIP	33422265
Intra	VPS41	P49754	VIPAS39	Homo sapiens	Q9H9C1	Anti Tag CoIP	19109425
Intra	VPS41	P49754	VIPAS39	Homo sapiens	Q9H9C1	Anti Bait CoIP	19109425

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Spinocerebellar Ataxia, Autosomal Recessive 29

SCAR29	Barakat-Van Ham-Kaya Syndrome
Bavahaka	Neurodevelopmental Disorder With Hypotonia And Cerebellar Ataxia
Nedhca	Spinocerebellar Ataxia, Autosomal Recessive, 29

Spinocerebellar Ataxia, Autosomal Recessive 4

SCAR4	Scasi
Spinocerebellar Ataxia With Saccadic Intrusions	Autosomal Recessive Cerebellar Ataxia-Saccadic Intrusion Syndrome
Spinocerebellar Ataxia 24	Autosomal Recessive Spinocerebellar Ataxia 4
Sca24	Spinocerebellar Ataxia 24, Formerly
Sca24, Formerly	Spinocerebellar Ataxia Autosomal Recessive 4
Autosomal Recessive Cerebellar Ataxia-Movement Disorder Syndrome

Chromosome 1q21.1 Duplication Syndrome

1q21.1 Microduplication Syndrome	Trisomy 1q21.1
1q21.1 Duplication Syndrome	1q21.1 Microduplication
1q21.1 Duplication	Dup(1)(Q21.1)

Atypical Neurofibroma

Cockayne Syndrome A

Cockayne Syndrome Type 1	Cockayne Syndrome, Type A
Cockayne Syndrome Type I	CSA
Cockayne Syndrome Classic Form	Cockayne Syndrome Classical
Cockayne Syndrome Type A	Ckn1

Dystonia

Dystonic Disease	Dystonic Disorder
Dystonia Disorders	Neuroleptic Dyskinesia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15691	VPS41 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	VPS41	RGD	RGD:1560511
Canis familiaris	VPS41	VGNC	VGNC:48291
Macaca mulatta	VPS41	VGNC	VGNC:78776
Felis catus	VPS41	VGNC	VGNC:66968
Mus musculus	VPS41	MGD	MGI:1929215
Bos taurus	VPS41	VGNC	VGNC:36823

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