2. Gene
  3. STX17 - syntaxin 17 Gene

STX17 - syntaxin 17 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 55014 | Gene type: protein coding

About STX17

Cytogenetic location: 9q31.1 Genomic coordinates (GRCh38): 9:99,906,654-99,974,534 (from NCBI)

This gene has 12 transcripts (splice variants), 169 orthologues and 12 paralogues. Ubiquitous expression in thyroid (RPKM 7.7), skin (RPKM 7.1) and 25 other tissues.

Summary

Enables SNAP receptor activity; SNARE binding activity; and protein Phosphatase binding activity. Involved in several processes, including autophagosome membrane docking; endoplasmic reticulum to Golgi vesicle-mediated transport; and endoplasmic reticulum-Golgi intermediate compartment organization. Acts upstream of or within protein localization to phagophore assembly site. Located in several cellular components, including autophagosome membrane; endoplasmic reticulum-Golgi intermediate compartment; and mitochondria-associated endoplasmic reticulum membrane. Part of SNARE complex. Colocalizes with HOPS complex. [provided by Alliance of Genome Resources, Apr 2022]

STX17 Products(1)

mRNA Protein Name
NM_017919.3 NP_060389.2 syntaxin-17
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables SNAP receptor activity IMP
IMP: Inferred from mutant phenotype
23217709 GOA
enables SNARE binding IDA
IDA: Inferred from direct assay
23217709 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23217709 GOA
enables protein phosphatase binding IPI
IPI: Inferred from physical interaction
23006999 GOA
Biological Process GO Annotation Evidence Reference Source
involved in Golgi organization IMP
IMP: Inferred from mutant phenotype
21545355 GOA
involved in autophagosome maturation IDA
IDA: Inferred from direct assay
28306502 GOA
involved in autophagosome maturation IMP
IMP: Inferred from mutant phenotype
23217709 GOA
involved in autophagosome membrane docking IDA
IDA: Inferred from direct assay
25686604 GOA
involved in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
IMP: Inferred from mutant phenotype
21545355 GOA
involved in endoplasmic reticulum-Golgi intermediate compartment organization IMP
IMP: Inferred from mutant phenotype
21545355 GOA
acts upstream of or within protein localization to phagophore assembly site IDA
IDA: Inferred from direct assay
23455425 GOA
Cellular Component GO Annotation Evidence Reference Source
part of HOPS complex IDA
IDA: Inferred from direct assay
24554770 GOA
part of SNARE complex IDA
IDA: Inferred from direct assay
23217709 GOA
located in autophagosome IDA
IDA: Inferred from direct assay
25686604 GOA
located in autophagosome membrane IDA
IDA: Inferred from direct assay
23217709 GOA
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
23217709 GOA
located in endoplasmic reticulum-Golgi intermediate compartment IDA
IDA: Inferred from direct assay
23006999 GOA
NOT located in lysosomal membrane IDA
IDA: Inferred from direct assay
10930465 GOA
located in mitochondria-associated endoplasmic reticulum membrane contact site IDA
IDA: Inferred from direct assay
23455425 GOA
NOT located in mitochondrion IDA
IDA: Inferred from direct assay
10930465 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
23217709 GOA
NOT located in rough endoplasmic reticulum IDA
IDA: Inferred from direct assay
10930465 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STX17 Protein Structure

SNARE

SNARE: SNARE domain (173 - 227)

  • 0
  • 100
  • 200
  • 302 a.a.
Protein Preferred Names Protein Names

syntaxin-17

STX17 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
STX17 P56962 ACSL3 Homo sapiens O95573
Anti Tag CoIP
29549094
Intra
STX17 P56962 ACSL3 Homo sapiens O95573
PLA
29549094
Intra
STX17 P56962 VPS41 Homo sapiens P49754
Anti Tag CoIP
24554770
Intra
STX17 P56962 VPS33A Homo sapiens Q96AX1
Anti Tag CoIP
24554770
Intra
STX17 P56962 VPS16 Homo sapiens Q9H269
Anti Tag CoIP
24554770
Intra
STX17 P56962 VPS16 Homo sapiens Q9H269
Confocal
24554770
Intra
STX17 P56962 SNAP29 Homo sapiens O95721
Anti Tag CoIP
25419848
Intra
STX17 P56962 SNAP29 Homo sapiens O95721
Anti Tag CoIP
23217709
Intra
STX17 P56962 SNAP29 Homo sapiens O95721
Anti Bait CoIP
25419848
Intra
STX17 P56962 SNAP29 Homo sapiens O95721
Anti Tag CoIP
33422265
Cross
STX17 P56962 Vamp7 Mus musculus P70280
Anti Tag CoIP
23217709
Intra
STX17 P56962 VAMP8 Homo sapiens Q9BV40
Anti Tag CoIP
23217709
Intra
STX17 P56962 VAMP8 Homo sapiens Q9BV40
Anti Bait CoIP
25419848
Intra
STX17 P56962 VAMP8 Homo sapiens Q9BV40
Anti Tag CoIP
33422265
Intra
STX17 P56962 VAMP8 Homo sapiens Q9BV40
Anti Tag CoIP
25419848
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Melanomatosis
Vici Syndrome

Absent Corpus Callosum Cataract Immunodeficiency

VICIS

Immunodeficiency With Cleft Lip/Palate, Cataract, Hypopigmentation, And Absent Corpus Callosum

Dionisi Vici Sabetta Gambarara Syndrome

Immunodeficiency With Cleft Lip/Palate, Cataract, Hypopigmentation And Absent Corpus Callosum

Corpus Callosum Agenesis-Cataract-Immunodeficiency Syndrome

Dionisi-Vici-Sabetta-Gambarara Syndrome

Immunodeficiency With Cleft Lip/Palate Cataract Hypopigmentation And Absent Corpus Callosum
Alopecia Areata

Aa

Alopecia Celsi

Alopecia Circumscripta

Cazenave'S Vitiligo

Celsus' Vitiligo

Diffuse Alopecia

Jonston'S Alopecia

Marginal Alopecia

Pseudopelade

Circumscribed Alopecia

Alopecia Cicatrisata

Patchy Alopecia

Alopecia

Aa - [Alopecia Areata]

Pelade
Alopecia Universalis Congenita

Alopecia Universalis

ALUNC

Atrichia, Generalized

Au

Alopecia Areata Universalis

Atrichia Generalized
Pontiac Fever
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-152100 CUR5g Inhibitor 98.69% Unkown
HY-RS13978 STX17 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus STX17 MGD MGI:1914977
Rattus norvegicus STX17 RGD RGD:708499
Macaca mulatta STX17 VGNC VGNC:78042
Felis catus STX17 VGNC VGNC:65808
Bos taurus STX17 VGNC VGNC:35433
Canis familiaris STX17 VGNC VGNC:46951