GFER - Gfer growth factor, augmenter of liver regeneration Gene

Rattus norvegicus

Also known as ALR

Gene ID: 27100 | Gene type: protein coding

About GFER

Summary

Enables flavin-linked sulfhydryl oxidase activity. Involved in several processes, including cellular response to actinomycin D; liver regeneration; and negative regulation of cell death. Located in cytosol; extracellular space; and mitochondrion. Used to study acute kidney failure. Biomarker of acute kidney failure; cryptorchidism; and ureteral obstruction. Human ortholog(s) of this gene implicated in kidney failure and renal fibrosis. Orthologous to human GFER (growth factor, augmenter of liver regeneration). [provided by Alliance of Genome Resources, Apr 2022]

GFER Products(1)

mRNA	Protein	Name
NM_013222.2	NP_037354.2	FAD-linked sulfhydryl oxidase ALR

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables flavin-dependent sulfhydryl oxidase activity	IDA IDA: Inferred from direct assay	11346147	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to actinomycin D	IEP IEP: Inferred from expression pattern	23073658	RGD
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	23073658	RGD
involved in cellular response to toxic substance	IEP IEP: Inferred from expression pattern	23073658	RGD
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	23073658	RGD
involved in liver regeneration	IMP IMP: Inferred from mutant phenotype	24880092	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	18272248	RGD
involved in negative regulation of natural killer cell mediated cytotoxicity	IDA IDA: Inferred from direct assay	9021955	RGD
involved in positive regulation of DNA biosynthetic process	IDA IDA: Inferred from direct assay	16937468	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	23073658	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	10216127	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

FAD-linked sulfhydryl oxidase ALR

FAD-linked sulfhydryl oxidase ALR-like	augmenter of liver regeneration
growth factor, erv1 homolog	growth factor, erv1-like (augmenter of liver regeneration)
translation initiation factor IF-2-like

Recombinant GFER Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71571	GFER Protein, Rat (His-SUMO)	Q63042 (M1-D198)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05377	GFER Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	GFER	NCBI	NCBI:2671

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