STK36 - serine/threonine kinase 36 Gene

Homo sapiens

Also known as FU; CILD46

Gene ID: 27148 | Gene type: protein coding

About STK36

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:218,672,086-218,702,717 (from NCBI)

This gene has 16 transcripts (splice variants), 201 orthologues, 1 paralogue and is associated with 2 phenotypes. Broad expression in testis (RPKM 24.8), gall bladder (RPKM 6.4) and 21 other tissues.

Summary

This gene encodes a member of the serine/threonine kinase family of Enzymes. This family member is similar to a Drosophila protein that plays a key role in the Hedgehog signaling pathway. This human protein is a positive regulator of the Gli zinc-finger transcription factors. Knockout studies of the homologous mouse gene suggest that defects in this human gene may lead to congenital hydrocephalus, possibly due to a functional defect in motile cilia. Because Hedgehog signaling is frequently activated in certain kinds of gastrointestinal cancers, it has been suggested that this gene is a target for the treatment of these cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]

STK36 Products(3)

mRNA	Protein	Name
NM_001243313.2	NP_001230242.1	serine/threonine-protein kinase 36 isoform 2
NM_001369423.1	NP_001356352.1	serine/threonine-protein kinase 36 isoform 1
NM_015690.5	NP_056505.2	serine/threonine-protein kinase 36 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10806483	GOA
enables protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	31279575	GOA
enables transcription corepressor binding	IDA IDA: Inferred from direct assay	10806483	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in axoneme assembly	IMP IMP: Inferred from mutant phenotype	28543983	GOA
involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	28543983	GOA
involved in regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	10806483	GOA
involved in smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	31279575	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10806483	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10806483	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STK36 Protein Structure

Pkinase

HEAT_2

0
300
600
900
1200
1315 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase 36

fused homolog

STK36 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	STK36	Q9NRP7	SUFU	Homo sapiens	Q9UMX1	Anti Tag CoIP	10806483

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Ciliary Dyskinesia, Primary, 46

CILD46

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome	Kartagener Syndrome
Dextrocardia Bronchiectasis And Sinusitis	Pcd
Ciliary Motility Disorders	Ciliary Motility Disorder
Immotile Ciliary Syndrome	Ciliary Dyskinesia Primary
Ics	Polynesian Bronchiectasis
Dextrocardia-Bronchiectasis-Sinusitis Syndrome	Immotile Cilia Syndrome, Kartagener Type
Primary Ciliary Dyskinesia And Situs Inversus	Primary Ciliary Dyskinesia, Kartagener Type
Siewert Syndrome	Dyskinesia, Ciliary, Primary

Congenital Hydrocephalus

Hydrocephalus	Hydrocephalus Adverse Event
Hydrocephalus, Nonsyndromic, Autosomal Recessive 1	Hydrocephalus In Newborn
Congenital Hydrocephaly

Hydrocephalus

Hydrocephalus, Nonsyndromic, Autosomal Recessive	Hydrocephalus, X-Linked
Hydrocephalus Adverse Event	Hydrocephaly Nos

Cervical Large Cell Neuroendocrine Carcinoma

Nivelon-Nivelon-Mabille Syndrome

Chondrodysplasia-Pseudohermaphroditism Syndrome	NNMS
Chondrodysplasia-Disorder Of Sex Development Syndrome	Nivelon Nivelon Mabille Syndrome

Chromosome 2q35 Duplication Syndrome

Syndactyly	Syndactyly Type 1
Sdty1	Zygodactyly
Syndactyly, Type I	Sd1
Syndactyly, Type 1, With Or Without Craniosynostosis	Symphalangism
Non-Syndromic Syndactyly	Symphalangy
Webbing Of Digits	Syndactyly, Type 1

Brachydactyly, Type A1

Brachydactyly Type A1	BDA1
Farabee-Type Brachydactyly	Farabee Type Brachydactyly
Brachydactyly Farabee Type	Brachydactyly, Farabee Type
Brachydactyly A1	Brachydactyly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13937	STK36 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	STK36	MGD	MGI:1920831
Rattus norvegicus	STK36	RGD	RGD:1307318
Macaca mulatta	STK36	VGNC	VGNC:78145
Canis familiaris	STK36	VGNC	VGNC:46918
Felis catus	STK36	VGNC	VGNC:65785
Bos taurus	STK36	VGNC	VGNC:35398

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