NAAA - N-acylethanolamine acid amidase Gene

Homo sapiens

Also known as PLT; ASAHL

Gene ID: 27163 | Gene type: protein coding

About NAAA

Cytogenetic location: 4q21.1 Genomic coordinates (GRCh38): 4:75,910,655-75,941,013 (from NCBI)

This gene has 9 transcripts (splice variants), 199 orthologues and 1 paralogue. Broad expression in prostate (RPKM 15.8), colon (RPKM 14.0) and 24 other tissues.

Summary

This gene encodes an N-acylethanolamine-hydrolyzing Enzyme which is highly similar to acid Ceramidase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

NAAA Products(3)

mRNA	Protein	Name
NM_001042402.2	NP_001035861.1	N-acylethanolamine-hydrolyzing acid amidase isoform 2 precursor
NM_001363719.2	NP_001350648.1	N-acylethanolamine-hydrolyzing acid amidase isoform 2 precursor
NM_014435.4	NP_055250.2	N-acylethanolamine-hydrolyzing acid amidase isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	21106534	GOA
enables N-(long-chain-acyl)ethanolamine deacylase activity	IDA IDA: Inferred from direct assay	15655246	GOA
enables N-acylsphingosine amidohydrolase activity	IDA IDA: Inferred from direct assay	15655246	GOA
enables fatty acid amide hydrolase activity	IDA IDA: Inferred from direct assay	15655246	GOA
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	IDA IDA: Inferred from direct assay	17980170	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in N-acylethanolamine metabolic process	IDA IDA: Inferred from direct assay	15655246	GOA
involved in N-acylphosphatidylethanolamine metabolic process	IDA IDA: Inferred from direct assay	22825852	GOA
involved in fatty acid metabolic process	IDA IDA: Inferred from direct assay	15655246	GOA
involved in sphingosine metabolic process	IDA IDA: Inferred from direct assay	15655246	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10610717	GOA
located in lysosome	IDA IDA: Inferred from direct assay	15655246	GOA
located in membrane	IDA IDA: Inferred from direct assay	30301806	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NAAA Protein Structure

NAAA-beta

CBAH

0
100
200
300
359 a.a.

Protein Preferred Names

Protein Names

N-acylethanolamine-hydrolyzing acid amidase

ASAH-like protein

Related Diseases

Diseases

Alias

Bleeding Disorder, Platelet-Type, 12

BDPLT12	Prostaglandin-Endoperoxide Synthase 1 Deficiency, Platelet
Pghs1 Deficiency	Platelet Cyclooxygenase 1 Deficiency
Platelet Cox1 Deficiency	Platelet-Type Bleeding Disorder 12
Platelet Prostaglandin-Endoperoxide Synthase 1 Deficiency

Vulvar Syringoma

Noonan Syndrome 10

NS10	Noonan Syndrome, Type 10

Charcot-Marie-Tooth Disease, Type 4j

Charcot-Marie-Tooth Disease Type 4j	CMT4J
Charcot-Marie-Tooth Disease, Autosomal Recessive, Type 4j	Autosomal Recessive Charcot-Marie-Tooth Disease Type 4j
Charcot-Marie-Tooth Disease 4j

Yunis-Varon Syndrome

Cleidocranial Dysplasia With Micrognathia, Absent Thumbs, And Distal Aphalangia	Yunis Varon Syndrome
YVS	Cleidocranial Dysplasia-Micrognathia-Absent Thumbs Syndrome
Cleidocranial Dysplasia, Micrognathia, Absent Thumbs, & Distal Aphalangia	Yunis-Varón Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0182	Carmofur	Inhibitor	99.95%	Unkown

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W074890	Palmitoylglycine	Modulator	99.74%	Unkown
HY-145339	ARN19702		99.80%	Unkown
HY-120813	ARN 077	Inhibitor	98.83%	Unkown
HY-147773	NAAA-IN-1		99.65%	Unkown
HY-124597	ARN726		95.00%	Unkown
HY-132882	ARN19689	Inhibitor	/	Unkown
HY-120813A	ARN 077 (enantiomer)	Inhibitor	99.71%	Unkown
HY-121975	N-Cyclohexanecarbonylpentadecylamine		/	Unkown
HY-147775	NAAA-IN-3		/	Unkown
HY-D2338	PMBD		/	Unkown
HY-RS08993	NAAA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-157223	ARN16186	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NAAA	VGNC	VGNC:75068
Mus musculus	NAAA	MGD	MGI:1914361
Felis catus	NAAA	VGNC	VGNC:68327
Bos taurus	NAAA	VGNC	VGNC:31854
Rattus norvegicus	NAAA	RGD	RGD:1307267

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