GLS2 - glutaminase 2 Gene

Homo sapiens

Also known as GA; GLS; LGA; hLGA

Gene ID: 27165 | Gene type: protein coding

About GLS2

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:56,470,952-56,488,161 (from NCBI)

This gene has 17 transcripts (splice variants), 252 orthologues and 1 paralogue. Biased expression in liver (RPKM 39.1), brain (RPKM 4.2) and 2 other tissues.

Summary

The protein encoded by this gene is a mitochondrial phosphate-activated Glutaminase that catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. Originally thought to be liver-specific, this protein has been found in Other tissues as well. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]

GLS2 Products(4)

mRNA	Protein	Name
NM_001280796.2	NP_001267725.1	glutaminase liver isoform, mitochondrial isoform 3
NM_001280797.2	NP_001267726.1	glutaminase liver isoform, mitochondrial isoform 4
NM_001280798.2	NP_001267727.1	glutaminase liver isoform, mitochondrial isoform 4
NM_013267.4	NP_037399.2	glutaminase liver isoform, mitochondrial isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11163757	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	20351271	GOA
acts upstream of or within regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	20351271	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrion	IDA IDA: Inferred from direct assay	20351271	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GLS2 Protein Structure

Glutaminase

Ank_2

0
100
200
300
400
500
602 a.a.

Protein Preferred Names

Protein Names

glutaminase liver isoform, mitochondrial

L-glutamine amidohydrolase

GLS2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GLS2	Q9UI32	XAF1	Homo sapiens	Q6GPH4	Y2H Prey Pooling	32296183
Intra	GLS2	Q9UI32	XAF1	Homo sapiens	Q6GPH4	Y2H Array	32296183
Intra	GLS2	Q9UI32	HIP1	Homo sapiens	O00291	Anti Tag CoIP	33961781
Intra	GLS2	Q9UI32	HIP1	Homo sapiens	O00291	Y2H Prey Pooling	32296183
Intra	GLS2	Q9UI32	HIP1	Homo sapiens	O00291	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Juvenile Dermatitis Herpetiformis

Metabolic Acidosis

Sclerosing Keratitis

Sclerokeratitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12248	Telaglenastat		99.82%	Phase 2
HY-12248A	Telaglenastat hydrochloride		/	Phase 2
HY-103671	IPN60090	Inhibitor	99.47%	Phase 1
HY-103671A	IPN60090 dihydrochloride	Inhibitor	99.68%	Phase 1

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-151434	GLS1 Inhibitor-6		/	Unkown
HY-RS05503	GLS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	GLS2	VGNC	VGNC:29420
Canis familiaris	GLS2	VGNC	VGNC:41277
Mus musculus	GLS2	MGD	MGI:2143539
Felis catus	GLS2	VGNC	VGNC:62595
Macaca mulatta	GLS2	VGNC	VGNC:73035
Rattus norvegicus	GLS2	RGD	RGD:620359

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