C5AR2 - complement C5a receptor 2 Gene

Homo sapiens

Also known as C5L2; GPF77; GPR77

Gene ID: 27202 | Gene type: protein coding

About C5AR2

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:47,332,175-47,347,329 (from NCBI)

This gene has 2 transcripts (splice variants), 152 orthologues and 8 paralogues. Broad expression in spleen (RPKM 2.6), appendix (RPKM 1.3) and 16 other tissues.

Summary

This gene encodes a G-protein coupled receptor 1 family member involved in the Complement System of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

C5AR2 Products(3)

mRNA	Protein	Name
NM_001271749.2	NP_001258678.1	C5a anaphylatoxin chemotactic receptor 2
NM_001271750.2	NP_001258679.1	C5a anaphylatoxin chemotactic receptor 2
NM_018485.3	NP_060955.1	C5a anaphylatoxin chemotactic receptor 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12540846	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	16204243	GOA
involved in negative regulation of neutrophil chemotaxis	IMP IMP: Inferred from mutant phenotype	16204243	GOA
involved in negative regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	16204243	GOA
involved in regulation of interleukin-8 production	IMP IMP: Inferred from mutant phenotype	22496247	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical part of cell	IDA IDA: Inferred from direct assay	22496247	GOA
located in basal plasma membrane	IDA IDA: Inferred from direct assay	22960554	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

C5AR2 Protein Structure

7tm_1

0
100
200
300
337 a.a.

Protein Preferred Names

Protein Names

C5a anaphylatoxin chemotactic receptor 2

C5a anaphylatoxin chemotactic receptor C5L2

C5AR2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	C5AR2	Q9P296	DCDC2	Homo sapiens	Q9UHG0	Validated Y2H	32296183
Intra	C5AR2	Q9P296	DCDC2	Homo sapiens	Q9UHG0	Y2H Array	32296183
Intra	C5AR2	Q9P296	DCDC2	Homo sapiens	Q9UHG0	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Complement Component 5 Deficiency

C5 Deficiency

C5D

Complement Component 3 Deficiency

C3 Deficiency

Hemolytic Uremic Syndrome, Atypical 1

Atypical Hemolytic-Uremic Syndrome	Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1
Atypical Hemolytic Uremic Syndrome	Hemolytic Uremic Syndrome, Atypical, Susceptibility To
Ahus	AHUS1
Hemolytic-Uremic Syndrome	Ahus 1
Ahus, Susceptibility To, 1	Hemolytic Uremic Syndrome, Atypical
Non-Shiga-Like Toxin-Associated Hus	Non-Stx-Hus
Nonenteropathic Hus	Atypical Hus
Shiga Toxin-Associated Hemolytic Uremic Syndrome	D+ Hus
Ehec-Hus	Hemolytic Uremic Syndrome Associated With Shiga Toxin-Producing Escherichia Coli
Hemolytic Uremic Syndrome With Diarrhea	Stec-Hus
Shiga-Like Toxin-Associated Hus	Stx-Hus
Typical Hus	Typical Hemolytic Uremic Syndrome
Atypical Hemolytic Uremic Syndrome With Anti-Factor H Antibodies	Atypical Hus With Anti-Factor H Antibodies
Ahus With Anti-Factor H Antibodies	Ahus With Neutralizing Autoantibodies Against Factor H
Hemolytic Uremic Syndrome Atypical 1	Atypical Hemolytic Uremic Syndrome With H Factor Anomaly
D Hus	Hemolytic-Uremic Syndrome Without Diarrhea
Hemolytic-Uremic Syndrome, Atypical, Type 1	Hemolytic Uremic Syndrome, Typical

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P10639	C5aR2 agonist P32	Agonist	99.82%	Unkown
HY-RS01751	C5AR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-P10639A	C5aR2 agonist P32 acetate	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	C5AR2	VGNC	VGNC:70690
Bos taurus	C5AR2	VGNC	VGNC:26642
Rattus norvegicus	C5AR2	RGD	RGD:1303027
Canis familiaris	C5AR2	VGNC	VGNC:38597
Mus musculus	C5AR2	MGD	MGI:2442013
Others	C5AR2	NCBI

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