PDCD4 - programmed cell death 4 Gene

Homo sapiens

Also known as H731

Gene ID: 27250 | Gene type: protein coding

About PDCD4

Cytogenetic location: 10q25.2 Genomic coordinates (GRCh38): 10:110,871,928-110,900,006 (from NCBI)

This gene has 11 transcripts (splice variants) and 203 orthologues. Ubiquitous expression in colon (RPKM 80.4), thyroid (RPKM 70.8) and 25 other tissues.

Summary

This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

PDCD4 Products(3)

mRNA	Protein	Name
NM_001199492.2	NP_001186421.1	programmed cell death protein 4 isoform 3
NM_014456.5	NP_055271.2	programmed cell death protein 4 isoform 1
NM_145341.4	NP_663314.1	programmed cell death protein 4 isoform 2

PDCD4 Protein Structure

MA3

0
100
200
300
400
469 a.a.

Protein Preferred Names

Protein Names

programmed cell death protein 4

neoplastic transformation inhibitor protein

Recombinant PDCD4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71191	PDCD4 Protein, Human (His)	Q53EL6 (K212-P357)	≥95%

Related Diseases

Diseases

Alias

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Ciliary Dyskinesia, Primary, 30

Primary Ciliary Dyskinesia 30	CILD30
Ciliary Dyskinesia, Primary, 30, With Or Without Situs Inversus	Primary Ciliary Dyskinesia 30 Without Situs Inversus
Primary Ciliary Dyskinesia 30 With Or Without Situs Inversus	Dyskinesia, Ciliary, Primary, Type 30

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148509	PhosTAC5		99.94%	Unkown
HY-148508	PhosTAC3		99.97%	Unkown
HY-153383	PDCD4-IN-1		99.65%	Unkown
HY-RS10192	PDCD4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PDCD4	VGNC	VGNC:75794
Rattus norvegicus	PDCD4	RGD	RGD:620816
Mus musculus	PDCD4	MGD	MGI:107490
Felis catus	PDCD4	VGNC	VGNC:68744
Bos taurus	PDCD4	VGNC	VGNC:32661
Canis familiaris	PDCD4	VGNC	VGNC:44338
Others	PDCD4	NCBI

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