PDCD4 - programmed cell death 4 Gene

Homo sapiens

Also known as H731

Gene ID: 27250 | Gene type: protein coding

About PDCD4

Cytogenetic location: 10q25.2 Genomic coordinates (GRCh38): 10:110,871,928-110,900,006 (from NCBI)

This gene has 11 transcripts (splice variants) and 203 orthologues. Ubiquitous expression in colon (RPKM 80.4), thyroid (RPKM 70.8) and 25 other tissues.

Summary

This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

PDCD4 Products(3)

mRNA	Protein	Name
NM_001199492.2	NP_001186421.1	programmed cell death protein 4 isoform 3
NM_014456.5	NP_055271.2	programmed cell death protein 4 isoform 1
NM_145341.4	NP_663314.1	programmed cell death protein 4 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12054647	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in BMP signaling pathway	IDA IDA: Inferred from direct assay	18548003	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	16357133	GOA
involved in negative regulation of myofibroblast differentiation	IMP IMP: Inferred from mutant phenotype	20533548	GOA
involved in negative regulation of vascular associated smooth muscle cell differentiation	IDA IDA: Inferred from direct assay	18548003	GOA
involved in negative regulation of vascular associated smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	28522568	GOA
involved in positive regulation of endothelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	24732886	GOA
involved in positive regulation of non-canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	19946272	GOA
involved in positive regulation of vascular associated smooth muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	28522568	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IMP IMP: Inferred from mutant phenotype	16357133	GOA
located in cytosol	IDA IDA: Inferred from direct assay	12054647	GOA
located in nucleus	IMP IMP: Inferred from mutant phenotype	16357133	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDCD4 Protein Structure

MA3

0
100
200
300
400
469 a.a.

Protein Preferred Names

Protein Names

programmed cell death protein 4

neoplastic transformation inhibitor protein

PDCD4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PDCD4	Q53EL6	APOE	Homo sapiens	P02649	Anti Bait CoIP	21163940
Intra	PDCD4	Q53EL6	EIF4A3	Homo sapiens	P38919	Y2H Prey Pooling	32296183
Intra	PDCD4	Q53EL6	EIF4A3	Homo sapiens	P38919	Validated Y2H	25416956
Intra	PDCD4	Q53EL6	EIF4A3	Homo sapiens	P38919	Y2H Array	25416956
Intra	PDCD4	Q53EL6	EIF4A3	Homo sapiens	P38919	Y2H Array	32296183
Intra	PDCD4	Q53EL6	RPS13	Homo sapiens	P62277	Y2H	12054647
Intra	PDCD4	Q53EL6	EIF4A1	Homo sapiens	P60842	Anti Bait CoIP	24413684
Intra	PDCD4	Q53EL6	EIF4A2	Homo sapiens	Q14240	Anti Bait CoIP	17353931
Intra	PDCD4	Q53EL6	EIF4A2	Homo sapiens	Q14240	Validated Y2H	25416956
Intra	PDCD4	Q53EL6	EIF4A2	Homo sapiens	Q14240	Y2H Array	25416956
Intra	PDCD4	Q53EL6	RELA	Homo sapiens	Q04206	Anti Tag CoIP	24413684
Intra	PDCD4	Q53EL6	RELA	Homo sapiens	Q04206	Anti Bait CoIP	24413684

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PDCD4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71191	PDCD4 Protein, Human (His)	Q53EL6 (K212-P357)	≥95%

Related Diseases

Diseases

Alias

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Ciliary Dyskinesia, Primary, 30

Primary Ciliary Dyskinesia 30	CILD30
Ciliary Dyskinesia, Primary, 30, With Or Without Situs Inversus	Primary Ciliary Dyskinesia 30 Without Situs Inversus
Primary Ciliary Dyskinesia 30 With Or Without Situs Inversus	Dyskinesia, Ciliary, Primary, Type 30

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-145232	PhosTAC7		98.96%	Unkown
HY-148509	PhosTAC5		99.94%	Unkown
HY-148508	PhosTAC3		99.97%	Unkown
HY-153383	PDCD4-IN-1		99.65%	Unkown
HY-RS10192	PDCD4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PDCD4	VGNC	VGNC:75794
Rattus norvegicus	PDCD4	RGD	RGD:620816
Mus musculus	PDCD4	MGD	MGI:107490
Felis catus	PDCD4	VGNC	VGNC:68744
Bos taurus	PDCD4	VGNC	VGNC:32661
Canis familiaris	PDCD4	VGNC	VGNC:44338
Others	PDCD4	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.