2. Gene
  3. MOCS3 - molybdenum cofactor synthesis 3 Gene

MOCS3 - molybdenum cofactor synthesis 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as UBA4

Gene ID: 27304 | Gene type: protein coding

About MOCS3

Cytogenetic location: 20q13.13 Genomic coordinates (GRCh38): 20:50,958,818-50,963,929 (from NCBI)

This gene has 1 transcript (splice variant), 195 orthologues and 9 paralogues.

Summary

Molybdenum cofactor (MoCo) is necessary for the function of all molybdoenzymes. The protein encoded by this gene adenylates and activates molybdopterin synthase, an Enzyme required for biosynthesis of MoCo. This gene contains no introns. A pseudogene of this gene is present on chromosome 14. [provided by RefSeq, Nov 2012]

MOCS3 Products(1)

mRNA Protein Name
NM_014484.5 NP_055299.1 adenylyltransferase and sulfurtransferase MOCS3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables URM1 activating enzyme activity IDA
IDA: Inferred from direct assay
19017811 GOA
enables molybdopterin-synthase sulfurtransferase activity IDA
IDA: Inferred from direct assay
15073332 GOA
enables molybdopterin-synthase sulfurtransferase activity IMP
IMP: Inferred from mutant phenotype
15073332 GOA
enables nucleotidyltransferase activity IDA
IDA: Inferred from direct assay
19017811 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18650437 GOA
enables sulfurtransferase activity IDA
IDA: Inferred from direct assay
15910006 GOA
enables sulfurtransferase activity IMP
IMP: Inferred from mutant phenotype
17459099 GOA
Biological Process GO Annotation Evidence Reference Source
involved in Mo-molybdopterin cofactor biosynthetic process IDA
IDA: Inferred from direct assay
15073332 GOA
involved in Mo-molybdopterin cofactor biosynthetic process IMP
IMP: Inferred from mutant phenotype
30817134 GOA
involved in molybdopterin cofactor metabolic process IDA
IDA: Inferred from direct assay
18650437 GOA
involved in tRNA thio-modification IDA
IDA: Inferred from direct assay
19017811 GOA
involved in tRNA thio-modification IMP
IMP: Inferred from mutant phenotype
30817134 GOA
involved in tRNA wobble uridine modification IDA
IDA: Inferred from direct assay
19017811 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
23593335 GOA
located in cytosol IDA
IDA: Inferred from direct assay
15073332 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MOCS3 Protein Structure

ThiF

ThiF: ThiF family (85 - 213)

(219 - 303)

Rhodanese

Rhodanese: Rhodanese-like domain (351 - 451)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 460 a.a.
Protein Preferred Names Protein Names

adenylyltransferase and sulfurtransferase MOCS3

MPT synthase sulfurylase

Related Diseases

Diseases Alias
Molybdenum Cofactor Deficiency

Combined Molybdoflavoprotein Enzyme Deficiency

Mocod

Combined Deficiency Of Sulfite Oxidase, Xanthine Dehydrogenase, And Aldehyde Oxidase

Combined Deficiency Of Sulfite Oxidase, Xanthine Dehydrogenase And Aldehyde Oxidase

Combined Xanthine Oxidase And Sulfite Oxidase And Aldehyde Oxidase Deficiency

Deficiency Of Molybdenum Cofactor

Deficiency, Molybdenum Cofactor
Molybdenum Cofactor Deficiency, Complementation Group C

MOCODC

Sulfite Oxidase Deficiency Due To Molybdenum Cofactor Deficiency Type C

Molybdenum Cofactor Deficiency C

Molybdenum Cofactor Deficiency Type C

Combined Deficiency Of Sulfite Oxidase, Xanthine Dehydrogenase And Aldehyde Oxidase Type C

Mocod Type C

Molybdenum Cofactor Deficiency Complementation Group C

Deficiency, Molybdenum Cofactor, Complementation Group C
Sulfite Oxidase Deficiency, Isolated

Sulfite Oxidase Deficiency

Sulfocysteinuria

Isolated Sulfite Oxidase Deficiency

ISOD

Encephalopathy Due To Sulfite Oxidase Deficiency
Molybdenum Cofactor Deficiency, Complementation Group A

MOCODA

Sulfite Oxidase Deficiency Due To Molybdenum Cofactor Deficiency Type A

Molybdenum Cofactor Deficiency A

Molybdenum Cofactor Deficiency Type A

Combined Deficiency Of Sulfite Oxidase, Xanthine Dehydrogenase And Aldehyde Oxidase Type A

Mocod Type A

Combined Deficiency Of Sulfite Oxidase, Xanthine Dehydrogenase, And Aldehyde Oxidase

Sulfite Oxidase, Xanthine Dehydrogenase, And Aldehyde Oxidase, Combined Deficiency Of

Molybdenum Cofactor Deficiency Complementation Group A

Molybdenum Cofactor Deficiency, Type A

Deficiency, Molybdenum Cofactor, Complementation Group A
Molybdenum Cofactor Deficiency, Complementation Group B

MOCODB

Sulfite Oxidase Deficiency Due To Molybdenum Cofactor Deficiency Type B

Molybdenum Cofactor Deficiency B

Molybdenum Cofactor Deficiency Type B

Combined Deficiency Of Sulfite Oxidase, Xanthine Dehydrogenase And Aldehyde Oxidase Type B

Mocod Type B

Molybdenum Cofactor Deficiency Complementation Group B

Deficiency, Molybdenum Cofactor, Complementation Group B
Neu-Laxova Syndrome 2

NLS2
Encephalomalacia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08582 MOCS3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris MOCS3 VGNC VGNC:43307
Bos taurus MOCS3 VGNC VGNC:31549
Macaca mulatta MOCS3 VGNC VGNC:74772
Rattus norvegicus MOCS3 RGD RGD:1307044
Mus musculus MOCS3 MGD MGI:1916622
Felis catus MOCS3 VGNC VGNC:63550