ANGPTL3 - angiopoietin like 3 Gene

Homo sapiens

Also known as ANL3; ANG-5; FHBL2; ANGPT5

Gene ID: 27329 | Gene type: protein coding

About ANGPTL3

Cytogenetic location: 1p31.3 Genomic coordinates (GRCh38): 1:62,597,520-62,606,313 (from NCBI)

This gene has 3 transcripts (splice variants), 257 orthologues, 25 paralogues and is associated with 2 phenotypes. Restricted expression toward liver (RPKM 171.2).

Summary

This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metabolism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2. [provided by RefSeq, Aug 2015]

ANGPTL3 Products(1)

mRNA	Protein	Name
NM_014495.4	NP_055310.1	angiopoietin-related protein 3 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables growth factor activity	IDA IDA: Inferred from direct assay	11877390	GOA
enables integrin binding	IPI IPI: Inferred from physical interaction	11877390	GOA
enables phospholipase inhibitor activity	IDA IDA: Inferred from direct assay	17110602	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in acylglycerol homeostasis	IDA IDA: Inferred from direct assay	17110602	GOA
involved in cell-matrix adhesion	IPI IPI: Inferred from physical interaction	11877390	GOA
involved in cholesterol homeostasis	IDA IDA: Inferred from direct assay	17110602	GOA
involved in cholesterol metabolic process	IDA IDA: Inferred from direct assay	17110602	GOA
involved in fatty acid metabolic process	IDA IDA: Inferred from direct assay	12565906	GOA
involved in glycerol metabolic process	IDA IDA: Inferred from direct assay	12565906	GOA
involved in lipid homeostasis	IDA IDA: Inferred from direct assay	17110602	GOA
involved in lipid storage	IDA IDA: Inferred from direct assay	12565906	GOA
involved in negative regulation of lipoprotein lipase activity	IDA IDA: Inferred from direct assay	17110602	GOA
involved in negative regulation of phospholipase activity	IDA IDA: Inferred from direct assay	17110602	GOA
involved in phospholipid catabolic process	IDA IDA: Inferred from direct assay	17110602	GOA
involved in phospholipid homeostasis	IDA IDA: Inferred from direct assay	17110602	GOA
involved in phospholipid metabolic process	IDA IDA: Inferred from direct assay	17110602	GOA
involved in positive regulation of angiogenesis	IDA IDA: Inferred from direct assay	11877390	GOA
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	11877390	GOA
involved in positive regulation of lipid catabolic process	IDA IDA: Inferred from direct assay	12565906	GOA
involved in signal transduction	IDA IDA: Inferred from direct assay	11877390	GOA
acts upstream of or within triglyceride homeostasis	IGI IGI: Inferred from genetic interaction	23150577	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	12565906	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	17110602	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANGPTL3 Protein Structure

Fibrinogen_C

0
100
200
300
400
460 a.a.

Protein Preferred Names

Protein Names

angiopoietin-related protein 3

angiopoietin 5

Recombinant ANGPTL3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7505	ANGPTL3/Angiopoietin-like 3 Protein, Human (HEK293, His)	Q9Y5C1 (S17-P220)	≥95%
HY-P75580	ANGPTL3/Angiopoietin-like 3 Protein, Human (sf9, His)	Q9Y5C1 (M1-E460)	≥95%
HY-P78059	ANGPTL3/Angiopoietin-like 3 Protein, Human (Biotinylated, HEK293, His-Avi)	Q9Y5C1 (S17-K219)	≥95%
HY-P78379	ANGPTL3/Angiopoietin-like 3 Protein, Human (HEK293, His-Avi)	Q9Y5C1 (S17-K219)	≥95%

Related Diseases

Diseases

Alias

Hypobetalipoproteinemia, Familial, 2

Familial Hypobetalipoproteinemia 2	FHBL2
Hypolipidemia, Familial, Combined	Combined Familial Hypolipidemia
Combined Hypobetalipoproteinemia Familial	Hypobetalipoproteinemia, Familial, Type 2

Hypobetalipoproteinemia, Familial, 1

Hypobetalipoproteinemia	Familial Hypobetalipoproteinemia 1
Familial Hypobetalipoproteinemia	FHBL1
Hypobetalipoproteinemia, Familial	Fhbl
Acanthocytosis With Hypobetalipoproteinemia	Hypobetalipoproteinemias
Hypobetalipoproteinemia, Normotriglyceridemic	Hypo-Beta-Lipoproteinemia
Hypobetalipoprotéinemia, Familial	Normotriglyceridemic Hypobetalipoproteinemia
Hypobetalipoproteinemia, Familial, Type 1

Nephrotic Syndrome

Finnish Congenital Nephrotic Syndrome	Ns - [Nephrotic Syndrome]
Nephrosis Syndrome	Nephrosis Nos
Glomerular Lesion Nephrosis

Atherosclerosis Susceptibility

Atherosclerosis	Atherosclerosis, Susceptibility To
ATHS	Atherogenic Lipoprotein Phenotype
Alp	Arteriosclerosis

Familial Hyperlipidemia

Familial Hyperlipoproteinemia	Hyperlipidaemia
Hyperlipoproteinemias	Hyperlipidemia
Hyperlipemia	Hyperlipidemias

Hyperlipoproteinemia, Type I

Lipoprotein Lipase Deficiency	Familial Chylomicronemia Syndrome
Lpl Deficiency	Hyperchylomicronemia, Familial
Hyperlipemia, Idiopathic, Burger-Grutz Type	Hyperlipemia, Essential Familial
Lipase D Deficiency	Lipd Deficiency
Hyperlipoproteinemia, Type Ia	Chylomicronemia, Familial
High Density Lipoprotein Cholesterol Level Qtl 11	Hyperlipoproteinemia Type 1
Hyperlipoproteinemia 1	HLPP1
Lipoprotein Lipase	Hyperlipoproteinemia Type I
Familial Hyperchylomicronemia Syndrome

Hypolipoproteinemia

Hypolipoproteinaemia	Lipoprotein Deficiencies
Lipoprotein Disorder	Hypolipoproteinemias
Lipoprotein	Lipoprotein Deficiency
Hypolipidaemia	Lipoprotein Deficiency Disorder
High-Density Lipoid Deficiency	High-Density Lipoprotein Deficiency
Dyslipidaemia, Depressed Hdl Cholesterol

Hyperlipoproteinemia, Type Iv

Hyperlipoproteinemia Type Iv	Carbohydrate-Inducible Hyperlipemia
Endogenous Hyperlipidaemia	Familial Hypertriglyceridemia
Fredrickson Type Iv Hyperlipoproteinemia	Fredrickson Type Iv Lipidaemia
Fredrickson Type Iv Lipidemia	Vldl Hyperlipoproteinemia
Hyperlipoproteinemia Type 4	Carbohydrate Inducible Hyperlipemia
Familial Type Iv Hyperlipoproteinemia	Familial Hyperlipoproteinemia Type Iv

Familial Lipoprotein Lipase Deficiency

Familial Lpl Deficiency	Familial Hyperchylomicronemia
Hyperlipoproteinemia Type I	Familial Hyperlipoproteinemia Type I
Hyperchylomicronemia	Burger-Grutz Syndrome
Endogenous Hypertriglyceridaemia	Familial Fat-Induced Hypertriglyceridemia
Lipd Deficiency	Lpl Deficiency
Lipase D Deficiency	Lipoprotein Lipase Deficiency, Familial
Familial Chylomicronemia Syndrome	Fredrickson Type I Hyperlipoproteinemia
Fredrickson Type I Lipaemia	Hypercholesterinaemic Xanthomatosis
Mixed Hyperglyceridemia	Lipoprotein Lipase Deficiency
Type I Hyperlipoproteinemia	Hyperlipoproteinemia Type Ia
Familial Hyperlipo-Proteinemia Type 1

Familial Apolipoprotein C-Ii Deficiency

Familial Apoc-Ii Deficiency	Familial Apoc2 Deficiency
C-Ii Anapolipoproteinemia	Hyperlipoproteinemia, Type 1b
Hyperlipoproteinemia, Type Ib	Hyperlipoproteinemia Type I

Hyperlipoproteinemia, Type V

Hyperlipoproteinemia Type V	Hyperchylomicronemia, Late-Onset
Familial Type 5 Hyperlipoproteinemia	Hyperchylomicronemia With Hyperprebetalipoproteinemia, Familial
Hyperlipidemia, Type V	Hyperlipemia, Mixed
Hyperlipemia, Combined Fat And Carbohydrate-Induced	Familial Hyperlipoproteinemia Type V
Fredrickson Type V Lipaemia	Hyperlipoproteinemia Type 5
Hyperchylomicronemia Late Onset	Hyperlipemia Combined Fat And Carbohydrate-Induced
Hyperlipemia Mixed	Hyperlipidemia Type V
Mixed Hyperlipemia	Type V Hyperlipoproteinemia
Hyperlipoproteinemia 5	HLPP5
Hyperlipidemia, Familial Combined	Mixed Hyperlipidemia

Hypoalphalipoproteinemia, Primary, 1

Familial Hdl Deficiency	Fha
High Density Lipoprotein Deficiency	Familial Hypoalphalipoproteinemia
Hypoalphalipoproteinemia, Familial	Hdld
Fhd	Hdl Deficiency, Type 2
Primary Hypoalphalipoproteinemia 1	Hdl Cholesterol, Low Serum
Hdlc	Hdl Deficiency, Familial, 1
Hypoalphalipoproteinemia, Primary	Low Serum Hdl Cholesterol
Primary Hypoalphalipoproteinemia	FHA1
Hdld2	High Density Lipoprotein Deficiency 2
Hypoalphalipoproteinemias	Apolipoprotein A-I Deficiency

Hyperlipidemia, Familial Combined, 3

Familial Combined Hyperlipidemia	Combined Hyperlipidemia, Familial
Mixed Hyperlipidaemia	FCHL3
Hyperlipidemia, Familial Combined	Familial Multiple Lipoprotein-Type Hyperlipidemia
Hyperbetalipoproteinemia With Prebetalipoproteinemia	Type Iib Hyperlipoproteinemia
Hyperlipidemia Familial Combined	Hyperlipoproteinemia Type Iib
Mixed Hyperlipemia	Hyperlipidaemia, Group C
Familial Hypercholesterolaemia With Hyperlipaemia	Familial Hyperbetalipoproteinaemia And Hyperprebetalipoproteinaemia
Hyperbetalipoproteinaemia With Prebetalipoproteinaemia	Hypercholesterolaemia With Endogenous Hyperglyceridaemia
Prebetalipoproteinemia Hyperbetalipoproteinaemia	Remnant Hyperlipoproteinemia

Familial Hypercholesterolemia

Hyperlipoproteinemia Type Iia	Familial Hyperbetalipoproteinaemia
Familial Hypercholesteremia	Fredrickson Type Iia Hyperlipoproteinemia
Fredrickson Type Iia Lipidaemia	Hyperbetalipoproteinemia
Type Ii Hyperlipidemia	Familial Hypercholesterolæmia
Familial Hypercholesterolaemia	Fh
Hypercholesterolemia Familial	Hyperlipoproteinemia Type Ii
Hypercholesterolemia, Familial

Lipid Metabolism Disorder

Dyslipidemia	Disorder Of Fatty Acid Metabolism
Lipid Metabolism Disorders	Fatty Acid Metabolism Disorder
Disorder Of Lipid Metabolism	Abnormality Of Lipid Metabolism
Lipid Metabolism, Inborn Errors	Dyslipidemias
Disorders Of Lipid Metabolism	Congenital Disorders Of Lipid Metabolism
Inherited Disorders Of Lipid Metabolism

Diabetes Mellitus

Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-153497	Vupanorsen	Inhibitor	92.29%	Phase 2
HY-153497A	Vupanorsen sodium	Inhibitor	92.29%	Phase 2

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ANGPTL3	VGNC	VGNC:99843
Canis familiaris	ANGPTL3	VGNC	VGNC:37859
Felis catus	ANGPTL3	VGNC	VGNC:67571
Bos taurus	ANGPTL3	VGNC	VGNC:25892
Rattus norvegicus	ANGPTL3	RGD	RGD:1564505
Mus musculus	ANGPTL3	MGD	MGI:1353627
Macaca fascicularis	ANGPTL3	NCBI	NCBI:102136264
Others	ANGPTL3	NCBI

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