HTATSF1 - HIV-1 Tat specific factor 1 Gene

Homo sapiens

Also known as TATSF1; TAT-SF1; dJ196E23.2

Gene ID: 27336 | Gene type: protein coding

About HTATSF1

Cytogenetic location: Xq26.3 Genomic coordinates (GRCh38): X:136,497,229-136,512,346 (from NCBI)

This gene has 4 transcripts (splice variants) and 217 orthologues. Ubiquitous expression in adrenal (RPKM 48.7), brain (RPKM 28.0) and 25 other tissues.

Summary

The protein encoded by this gene functions as a cofactor for the stimulation of transcriptional elongation by HIV-1 Tat, which binds to the HIV-1 promoter through Tat-TAR interaction. This protein may also serve as a dual-function factor to couple transcription and splicing and to facilitate their reciprocal activation. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Sep 2009]

HTATSF1 Products(2)

mRNA	Protein	Name
NM_001163280.2	NP_001156752.1	HIV Tat-specific factor 1
NM_014500.5	NP_055315.2	HIV Tat-specific factor 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chromatin-protein adaptor activity	IDA IDA: Inferred from direct assay	35597237	GOA
enables poly-ADP-D-ribose modification-dependent protein binding	IDA IDA: Inferred from direct assay	35597237	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17332742	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in U2-type prespliceosome assembly	IDA IDA: Inferred from direct assay	32494006	GOA
involved in double-strand break repair via homologous recombination	IDA IDA: Inferred from direct assay	35597237	GOA
involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	32494006	GOA
involved in protein localization to site of double-strand break	IDA IDA: Inferred from direct assay	35597237	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of U2-type spliceosomal complex	IDA IDA: Inferred from direct assay	32494006	GOA
is active in site of double-strand break	IDA IDA: Inferred from direct assay	35597237	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HTATSF1 Protein Structure

RRM_1

RRM_5

0
200
400
600
755 a.a.

Protein Preferred Names

Protein Names

HIV Tat-specific factor 1

HIV TAT specific factor 1

HTATSF1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HTATSF1	O43719	SF3B1	Homo sapiens	O75533-1	ITC	30567737
Intra	HTATSF1	O43719	SF3B1	Homo sapiens	O75533-1	X-Ray Diffraction	30567737
Intra	HTATSF1	O43719	SF3B1	Homo sapiens	O75533-1	Pull Down	30567737
Intra	HTATSF1	O43719	SF3B1	Homo sapiens	O75533-1	Anti Bait CoIP	30567737

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06454	HTATSF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HTATSF1	MGD	MGI:1919709
Bos taurus	HTATSF1	VGNC	VGNC:29990
Macaca mulatta	HTATSF1	VGNC	VGNC:73535
Felis catus	HTATSF1	VGNC	VGNC:67666
Canis familiaris	HTATSF1	VGNC	VGNC:41822
Rattus norvegicus	HTATSF1	RGD	RGD:1563377

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