2. Gene
  3. GMPR - guanosine monophosphate reductase Gene

GMPR - guanosine monophosphate reductase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GMPR1; GMPR 1

Gene ID: 2766 | Gene type: protein coding

About GMPR

Cytogenetic location: 6p22.3 Genomic coordinates (GRCh38): 6:16,238,587-16,295,549 (from NCBI)

This gene has 4 transcripts (splice variants), 208 orthologues and 3 paralogues. Broad expression in prostate (RPKM 33.0), testis (RPKM 29.5) and 19 other tissues.

Summary

This gene encodes an Enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of GMP to IMP. The protein also functions in the re-utilization of free intracellular Bases and purine nucleosides.[provided by RefSeq, Oct 2009]

GMPR Products(1)

mRNA Protein Name
NM_006877.4 NP_006868.3 GMP reductase 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables GMP reductase activity IDA
IDA: Inferred from direct assay
22332716 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
33961781 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GMPR Protein Structure

IMPDH

IMPDH: IMP dehydrogenase / GMP reductase domain (9 - 341)

  • 0
  • 100
  • 200
  • 300
  • 345 a.a.
Protein Preferred Names Protein Names

GMP reductase 1

guanine monophosphate reductase

GMPR Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
GMPR P36959 GMPR2 Homo sapiens Q9P2T1
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GMPR Proteins

Cat. No. Product Name Accession Purity
HY-P70955 GMPR Protein, Human (HEK293, His) AAH08281.1 (M1-S345) ≥95%
HY-P75791 GMPR Protein, Human (His) P36959/NP_006868.3 (M1-S345) ≥95%

Related Diseases

Diseases Alias
Viral Gastritis
Cystathioninuria

Cystathionase Deficiency

Gamma-Cystathionase Deficiency

Cystathione Gamma-Lyase Deficiency Syndrome

Cystathionine Gamma-Lyase Deficiency Syndrome

CSTNU
Fumarase Deficiency

Fumaric Aciduria

FMRD

Fumarate Hydratase Deficiency

Deficiency, Fumarase
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05526 GMPR Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS05527 GMPR2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GMPR MGD MGI:1913605
Macaca mulatta GMPR VGNC VGNC:73082
Rattus norvegicus GMPR RGD RGD:70980
Felis catus GMPR VGNC VGNC:62612
Canis familiaris GMPR VGNC VGNC:41294
Bos taurus GMPR VGNC VGNC:29442
Others GMPR NCBI