GNG10 - G protein subunit gamma 10 Gene

Homo sapiens

Gene ID: 2790 | Gene type: protein coding

About GNG10

Cytogenetic location: 9q31.3 Genomic coordinates (GRCh38): 9:111,661,605-111,670,226 (from NCBI)

This gene has 1 transcript (splice variant), 175 orthologues and 11 paralogues. Ubiquitous expression in appendix (RPKM 57.2), adrenal (RPKM 51.1) and 25 other tissues.

Summary

Predicted to enable G-protein beta-subunit binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be part of heterotrimeric G-protein complex. [provided by Alliance of Genome Resources, Apr 2022]

GNG10 Products(2)

mRNA	Protein	Name
NM_001017998.4	NP_001017998.1	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
NM_001198664.2	NP_001185593.1	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GNG10 Protein Structure

G-gamma

0
68 a.a.

Protein Preferred Names

Protein Names

guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10

guanine nucleotide binding protein (G protein), gamma 10

GNG10 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GNG10	P50151	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	GNG10	P50151	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	GNG10	P50151	KRT38	Homo sapiens	O76015	Y2H Array	31515488
Intra	GNG10	P50151	KRT38	Homo sapiens	O76015	Y2H Prey Pooling	25416956
Intra	GNG10	P50151	KRT38	Homo sapiens	O76015	Y2H Array	25416956
Intra	GNG10	P50151	KRT38	Homo sapiens	O76015	Y2H Array	29892012
Intra	GNG10	P50151	KRT16	Homo sapiens	P08779	Y2H Array	32296183
Intra	GNG10	P50151	KRT16	Homo sapiens	P08779	Y2H Prey Pooling	32296183
Intra	GNG10	P50151	TCF4	Homo sapiens	P15884	Y2H Prey Pooling	25416956
Intra	GNG10	P50151	TCF4	Homo sapiens	P15884	Y2H Array	25416956
Intra	GNG10	P50151	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Good Syndrome

Immunodeficiency With Thymoma	Thymoma-Immunodeficiency Syndrome
Thymoma With Hypogammaglobulinemia	Thymoma Immunodeficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05552	GNG10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	GNG10	VGNC	VGNC:56971
Canis familiaris	GNG10	VGNC	VGNC:97200
Rattus norvegicus	GNG10	RGD	RGD:621514
Mus musculus	GNG10	MGD	MGI:1336169

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