2. Gene
  3. KRT38 - keratin 38 Gene

KRT38 - keratin 38 Gene

  • Gene
  • Protein
  • Disease
  • Agent
Homo sapiens

Also known as HA8; hHa8; KRTHA8

Gene ID: 8687 | Gene type: protein coding

About KRT38

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:41,436,154-41,440,983 (from NCBI)

This gene has 1 transcript (splice variant), 29 orthologues and 68 paralogues. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]

KRT38 Products(1)

mRNA Protein Name
NM_006771.4 NP_006762.3 keratin, type I cuticular Ha8
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KRT38 Protein Structure

Filament

Filament: Intermediate filament protein (104 - 414)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 456 a.a.
Protein Preferred Names Protein Names

keratin, type I cuticular Ha8

K38

KRT38 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
KRT38 O76015 CEP57L1 Homo sapiens Q8IYX8-2
Validated Y2H
25416956
Intra
KRT38 O76015 AMOTL2 Homo sapiens Q9Y2J4-4
Validated Y2H
25416956
Intra
KRT38 O76015 AMOTL2 Homo sapiens Q9Y2J4-4
Y2H Prey Pooling
25416956
Intra
KRT38 O76015 GNG10 Homo sapiens P50151
Validated Y2H
25416956
Intra
KRT38 O76015 KRT83 Homo sapiens P78385
Validated Y2H
32296183
Intra
KRT38 O76015 KRT83 Homo sapiens P78385
Y2H Array
25416956
Intra
KRT38 O76015 PTGER3 Homo sapiens P43115-12
Y2H Prey Pooling
25416956
Intra
KRT38 O76015 PTGER3 Homo sapiens P43115-12
Validated Y2H
25416956
Intra
KRT38 O76015 PTGER3 Homo sapiens P43115-12
Y2H Array
25416956
Intra
KRT38 O76015 CCDC146 Homo sapiens Q8IYE0-2
Y2H Prey Pooling
25416956
Intra
KRT38 O76015 CCDC146 Homo sapiens Q8IYE0-2
Y2H Array
25416956
Intra
KRT38 O76015 CCDC146 Homo sapiens Q8IYE0-2
Validated Y2H
25416956
Intra
KRT38 O76015 RHPN1-AS1 Homo sapiens Q9BWJ2
Validated Y2H
25416956
Intra
KRT38 O76015 CD300A Homo sapiens Q9UGN4
Validated Y2H
25416956
Intra
KRT38 O76015 KRT85 Homo sapiens P78386
Validated Y2H
32296183
Intra
KRT38 O76015 CCDC146 Homo sapiens Q8IYE0
Validated Y2H
32296183
Intra
KRT38 O76015 TRIML2 Homo sapiens Q8N7C3
Validated Y2H
32296183
Intra
KRT38 O76015 GNG13 Homo sapiens Q9P2W3
Validated Y2H
32296183
Intra
KRT38 O76015 LMO3 Homo sapiens Q8TAP4-4
Validated Y2H
32296183
Intra
KRT38 O76015 KRT80 Homo sapiens Q6KB66-2
Validated Y2H
32296183
Intra
KRT38 O76015 TBC1D21 Homo sapiens Q8IYX1
Validated Y2H
32296183
Intra
KRT38 O76015 HSF4 Homo sapiens Q9ULV5-2
Validated Y2H
32296183
Intra
KRT38 O76015 KRT72 Homo sapiens Q14CN4
Validated Y2H
32296183
Intra
KRT38 O76015 KRT72 Homo sapiens Q14CN4
Y2H Array
32296183
Intra
KRT38 O76015 KRT2 Homo sapiens P35908
Y2H Array
31515488
Intra
KRT38 O76015 KRT2 Homo sapiens P35908
Validated Y2H
25416956
Intra
KRT38 O76015 KRT2 Homo sapiens P35908
Y2H Prey Pooling
25416956
Intra
KRT38 O76015 KIFC3 Homo sapiens Q9BVG8-5
Validated Y2H
32296183
Intra
KRT38 O76015 POU4F2 Homo sapiens Q12837
Validated Y2H
32296183
Intra
KRT38 O76015 FAM110A Homo sapiens Q9BQ89
Validated Y2H
32296183
Intra
KRT38 O76015 KRT4 Homo sapiens P19013
Validated Y2H
32296183
Intra
KRT38 O76015 KRT4 Homo sapiens P19013
Y2H Prey Pooling
25416956
Intra
KRT38 O76015 KRT3 Homo sapiens P12035
Validated Y2H
32296183
Intra
KRT38 O76015 KRT79 Homo sapiens Q5XKE5
Y2H Array
31515488
Intra
KRT38 O76015 KRT79 Homo sapiens Q5XKE5
Y2H Prey Pooling
25416956
Intra
KRT38 O76015 HAUS1 Homo sapiens Q96CS2
Anti Tag CoIP
33961781
Intra
KRT38 O76015 KRT6C Homo sapiens P48668
Y2H Array
25416956
Intra
KRT38 O76015 KRT6C Homo sapiens P48668
Validated Y2H
25416956
Intra
KRT38 O76015 KRT6C Homo sapiens P48668
Validated Y2H
32296183
Intra
KRT38 O76015 LMO4 Homo sapiens P61968
Validated Y2H
32296183
Intra
KRT38 O76015 TXNDC5 Homo sapiens Q86UY0
Y2H Prey Pooling
25416956
Intra
KRT38 O76015 TXNDC5 Homo sapiens Q86UY0
Validated Y2H
25416956
Intra
KRT38 O76015 ZFYVE21 Homo sapiens Q9BQ24
Y2H Prey Pooling
25416956
Intra
KRT38 O76015 KRT75 Homo sapiens O95678
Validated Y2H
32296183
Intra
KRT38 O76015 KRT71 Homo sapiens Q3SY84
Validated Y2H
25416956
Intra
KRT38 O76015 KRT71 Homo sapiens Q3SY84
Validated Y2H
32296183
Intra
KRT38 O76015 KRT71 Homo sapiens Q3SY84
Y2H Array
25416956
Intra
KRT38 O76015 KRT76 Homo sapiens Q01546
Validated Y2H
32296183
Intra
KRT38 O76015 KRT8 Homo sapiens P05787
Validated Y2H
25416956
Intra
KRT38 O76015 KRT8 Homo sapiens P05787
Validated Y2H
32296183
Intra
KRT38 O76015 KRT8 Homo sapiens P05787
Y2H Array
25416956
Intra
KRT38 O76015 KRT8 Homo sapiens P05787
Y2H Prey Pooling
25416956
Intra
KRT38 O76015 KRT1 Homo sapiens P04264
Validated Y2H
32296183
Intra
KRT38 O76015 HDAC4 Homo sapiens P56524
Y2H Prey Pooling
25416956
Intra
KRT38 O76015 PIK3R2 Homo sapiens O00459
Validated Y2H
25416956
Intra
KRT38 O76015 PIK3R2 Homo sapiens O00459
Y2H Prey Pooling
25416956
Intra
KRT38 O76015 PSMC5 Homo sapiens P62195
Validated Y2H
25416956
Intra
KRT38 O76015 PSMC5 Homo sapiens P62195
Y2H Array
25416956
Intra
KRT38 O76015 PSMC5 Homo sapiens P62195
Y2H Array
29892012
Intra
KRT38 O76015 PSMC5 Homo sapiens P62195
Y2H Prey Pooling
25416956
Intra
KRT38 O76015 SMARCD1 Homo sapiens Q96GM5
Validated Y2H
32296183
Intra
KRT38 O76015 PSMA1 Homo sapiens P25786
Validated Y2H
32296183
Intra
KRT38 O76015 PSMA1 Homo sapiens P25786
Y2H Array
25416956
Intra
KRT38 O76015 PSMA1 Homo sapiens P25786
Y2H Prey Pooling
25416956
Intra
KRT38 O76015 TXLNA Homo sapiens P40222
Anti Tag CoIP
33961781
Intra
KRT38 O76015 TXLNA Homo sapiens P40222
Y2H Array
31515488
Intra
KRT38 O76015 GLRX3 Homo sapiens O76003
Y2H Array
25416956
Intra
KRT38 O76015 UTP23 Homo sapiens Q9BRU9
Validated Y2H
32296183
Intra
KRT38 O76015 TXLNB Homo sapiens Q8N3L3
Validated Y2H
32296183
Intra
KRT38 O76015 TXLNB Homo sapiens Q8N3L3
Y2H Array
32296183
Intra
KRT38 O76015 TXLNB Homo sapiens Q8N3L3
Y2H Array
31515488
Intra
KRT38 O76015 KLHL38 Homo sapiens Q2WGJ6
Y2H Array
25416956
Intra
KRT38 O76015 KLHL38 Homo sapiens Q2WGJ6
Validated Y2H
25416956
Intra
KRT38 O76015 KLHL38 Homo sapiens Q2WGJ6
Validated Y2H
32296183
Intra
KRT38 O76015 ZNF587 Homo sapiens Q96SQ5
Y2H Array
25416956
Intra
KRT38 O76015 FAM90A1 Homo sapiens Q86YD7
Y2H Prey Pooling
25416956
Intra
KRT38 O76015 FAM90A1 Homo sapiens Q86YD7
Validated Y2H
25416956
Intra
KRT38 O76015 FAM90A1 Homo sapiens Q86YD7
Y2H Array
25416956
Intra
KRT38 O76015 KRT5 Homo sapiens P13647
Validated Y2H
32296183
Intra
KRT38 O76015 KRT5 Homo sapiens P13647
Y2H Array
25416956
Intra
KRT38 O76015 KRT6A Homo sapiens P02538
Validated Y2H
32296183
Intra
KRT38 O76015 KRT6A Homo sapiens P02538
Y2H Array
31515488
Intra
KRT38 O76015 KRT6A Homo sapiens P02538
Validated Y2H
25416956
Intra
KRT38 O76015 HMG20B Homo sapiens Q9P0W2
MAPPIT
25416956
Intra
KRT38 O76015 HMG20B Homo sapiens Q9P0W2
Y2H Array
25416956
Intra
KRT38 O76015 PIN1 Homo sapiens Q13526
Validated Y2H
25416956
Intra
KRT38 O76015 PIN1 Homo sapiens Q13526
Validated Y2H
32296183
Intra
KRT38 O76015 ZNF20 Homo sapiens P17024
Y2H Prey Pooling
25416956
Intra
KRT38 O76015 ZNF20 Homo sapiens P17024
Validated Y2H
25416956
Intra
KRT38 O76015 KRT81 Homo sapiens Q14533
Y2H Array
25416956
Intra
KRT38 O76015 KRT81 Homo sapiens Q14533
Validated Y2H
25416956
Intra
KRT38 O76015 KRT81 Homo sapiens Q14533
Validated Y2H
32296183
Intra
KRT38 O76015 KRT81 Homo sapiens Q14533
Anti Tag CoIP
25416956
Intra
KRT38 O76015 USHBP1 Homo sapiens Q8N6Y0
Validated Y2H
25416956
Intra
KRT38 O76015 USHBP1 Homo sapiens Q8N6Y0
Validated Y2H
32296183
Intra
KRT38 O76015 HGS Homo sapiens O14964
Validated Y2H
25416956
Intra
KRT38 O76015 HGS Homo sapiens O14964
Y2H Array
25416956
Intra
KRT38 O76015 ZNF417 Homo sapiens Q8TAU3
Validated Y2H
25416956
Intra
KRT38 O76015 ZNF417 Homo sapiens Q8TAU3
Validated Y2H
32296183
Intra
KRT38 O76015 ZNF417 Homo sapiens Q8TAU3
Y2H Prey Pooling
25416956
Intra
KRT38 O76015 ZNF417 Homo sapiens Q8TAU3
Y2H Array
25416956
Intra
KRT38 O76015 HOXA1 Homo sapiens P49639
Validated Y2H
32296183
Intra
KRT38 O76015 HOXA1 Homo sapiens P49639
Validated Y2H
25416956
Intra
KRT38 O76015 HOXA1 Homo sapiens P49639
Y2H Prey Pooling
25416956
Intra
KRT38 O76015 HOXA1 Homo sapiens P49639
Y2H Array
25416956
Intra
KRT38 O76015 KRT6B Homo sapiens P04259
Y2H Array
25416956
Intra
KRT38 O76015 KRT6B Homo sapiens P04259
Validated Y2H
32296183
Intra
KRT38 O76015 KRT6B Homo sapiens P04259
Complementation
32296183
Intra
KRT38 O76015 BRME1 Homo sapiens Q0VDD7
Y2H Array
25416956
Intra
KRT38 O76015 ABI3 Homo sapiens Q9P2A4
Validated Y2H
32296183
Intra
KRT38 O76015 CCDC120 Homo sapiens Q96HB5
Validated Y2H
32296183
Intra
KRT38 O76015 ANKRD36BP1 Homo sapiens Q96IX9
Y2H Array
25416956
Intra
KRT38 O76015 C1orf216 Homo sapiens Q8TAB5
Validated Y2H
32296183
Intra
KRT38 O76015 C1orf216 Homo sapiens Q8TAB5
Y2H Array
25416956
Intra
KRT38 O76015 C1orf216 Homo sapiens Q8TAB5
Y2H Prey Pooling
25416956
Intra
KRT38 O76015 SCNM1 Homo sapiens Q9BWG6
Validated Y2H
25416956
Intra
KRT38 O76015 SCNM1 Homo sapiens Q9BWG6
Y2H Prey Pooling
25416956
Intra
KRT38 O76015 SCNM1 Homo sapiens Q9BWG6
Validated Y2H
32296183
Intra
KRT38 O76015 SCNM1 Homo sapiens Q9BWG6
Y2H Array
31515488
Intra
KRT38 O76015 MAGEB4 Homo sapiens O15481
Validated Y2H
25416956
Intra
KRT38 O76015 MAGEB4 Homo sapiens O15481
Y2H Array
25416956
Intra
KRT38 O76015 DMRT3 Homo sapiens Q9NQL9
Validated Y2H
32296183
Intra
KRT38 O76015 KRT74 Homo sapiens Q7RTS7
Validated Y2H
32296183
Intra
KRT38 O76015 a8k2r3_human Homo sapiens A8K2R3
Y2H Prey Pooling
25416956
Intra
KRT38 O76015 a8k2r3_human Homo sapiens A8K2R3
Y2H Array
25416956
Intra
KRT38 O76015 a8k2r3_human Homo sapiens A8K2R3
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Nodular Basal Cell Carcinoma

Basal Cell Carcinoma, Nodular

Circumscribed Solid Basal Cell Carcinoma

Skin Nodulo-Ulcerative Basal Cell Carcinoma

Skin Solid Basal Cell Carcinoma

Skin Nodular Basal Cell Carcinoma

Skin Nodular Solid Basal Cell Carcinoma

Nodulo-Ulcerative Basal Cell Carcinoma

Circumscribed Solid Basal Cell Carcinoma Of Skin
Nail Disorder, Nonsyndromic Congenital, 4

Anonychia Congenita

Anonychia

Hyponychia Congenita

NDNC4

Anonychia/Hyponychia Congenita

Nonsyndromic Congenital Nail Disorder 4

Isolated Congenital Anonychia

Anonychia Congenita Totalis

Anonychia Totalis

Autosomal Recessive Nonsyndromic Congenital Nail Disorder-4

Congenital Anonychia

Nonsyndromic Congenital Nail Disorder, 4

Absent Nails

Aplastic Nails

Congenital Absence Of Nails

Isolated Anonychia

Nail Disorder, Non-Syndromic Congenital, 4

Nail Disorder, Nonsyndromic, Congenital, Type 4
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07454 KRT38 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown