TCF4 - transcription factor 4 Gene

Homo sapiens

Also known as E2-2; ITF2; PTHS; SEF2; CDG2T; FECD3; ITF-2; SEF-2; TCF-4; SEF2-1; SEF2-1A; SEF2-1B; SEF2-1D; bHLHb19

Gene ID: 6925 | Gene type: protein coding

About TCF4

Cytogenetic location: 18q21.2 Genomic coordinates (GRCh38): 18:55,222,185-55,635,957 (from NCBI)

This gene has 93 transcripts (splice variants), 213 orthologues, 2 paralogues and is associated with 8 phenotypes. Ubiquitous expression in brain (RPKM 17.0), fat (RPKM 14.9) and 24 other tissues.

Summary

This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. In addition, an intronic CTG repeat normally numbering 10-37 repeat units can expand to >50 repeat units and cause Fuchs endothelial corneal dystrophy. Multiple alternatively spliced transcript variants that encode different proteins have been described. [provided by RefSeq, Jul 2016]

TCF4 Products(46)

mRNA	Protein	Name
NM_001083962.2	NP_001077431.1	transcription factor 4 isoform a
NM_001243226.3	NP_001230155.2	transcription factor 4 isoform c
NM_001243227.2	NP_001230156.1	transcription factor 4 isoform d
NM_001243228.2	NP_001230157.1	transcription factor 4 isoform e
NM_001243230.2	NP_001230159.1	transcription factor 4 isoform f
NM_001243231.2	NP_001230160.1	transcription factor 4 isoform g
NM_001243232.1	NP_001230161.1	transcription factor 4 isoform h
NM_001243233.2	NP_001230162.1	transcription factor 4 isoform i
NM_001243234.2	NP_001230163.1	transcription factor 4 isoform j
NM_001243235.2	NP_001230164.1	transcription factor 4 isoform k
NM_001243236.2	NP_001230165.1	transcription factor 4 isoform l
NM_001306207.1	NP_001293136.1	transcription factor 4 isoform m
NM_001306208.1	NP_001293137.1	transcription factor 4 isoform n
NM_001330604.3	NP_001317533.1	transcription factor 4 isoform o
NM_001330605.3	NP_001317534.1	transcription factor 4 isoform p
NM_001348211.2	NP_001335140.1	transcription factor 4 isoform q
NM_001348212.2	NP_001335141.1	transcription factor 4 isoform i
NM_001348213.2	NP_001335142.1	transcription factor 4 isoform p
NM_001348214.2	NP_001335143.1	transcription factor 4 isoform r
NM_001348215.2	NP_001335144.1	transcription factor 4 isoform s
NM_001348216.2	NP_001335145.1	transcription factor 4 isoform t
NM_001348217.1	NP_001335146.1	transcription factor 4 isoform d
NM_001348218.2	NP_001335147.1	transcription factor 4 isoform d
NM_001348219.2	NP_001335148.1	transcription factor 4 isoform m
NM_001348220.1	NP_001335149.1	transcription factor 4 isoform u
NM_001369567.1	NP_001356496.1	transcription factor 4 isoform a
NM_001369568.1	NP_001356497.1	transcription factor 4 isoform a
NM_001369569.1	NP_001356498.1	transcription factor 4 isoform v
NM_001369570.1	NP_001356499.1	transcription factor 4 isoform v
NM_001369571.1	NP_001356500.1	transcription factor 4 isoform b
NM_001369572.1	NP_001356501.1	transcription factor 4 isoform b
NM_001369573.1	NP_001356502.1	transcription factor 4 isoform x
NM_001369574.1	NP_001356503.1	transcription factor 4 isoform 27
NM_001369575.1	NP_001356504.1	transcription factor 4 isoform d
NM_001369576.1	NP_001356505.1	transcription factor 4 isoform y
NM_001369577.1	NP_001356506.1	transcription factor 4 isoform 28
NM_001369578.1	NP_001356507.1	transcription factor 4 isoform y
NM_001369579.1	NP_001356508.1	transcription factor 4 isoform 28
NM_001369580.1	NP_001356509.1	transcription factor 4 isoform 28
NM_001369581.1	NP_001356510.1	transcription factor 4 isoform y
NM_001369582.1	NP_001356511.1	transcription factor 4 isoform m
NM_001369583.1	NP_001356512.1	transcription factor 4 isoform m
NM_001369584.1	NP_001356513.1	transcription factor 4 isoform u
NM_001369585.1	NP_001356514.1	transcription factor 4 isoform u
NM_001369586.1	NP_001356515.1	transcription factor 4 isoform z
NM_003199.3	NP_003190.1	transcription factor 4 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	1681116	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	2105528	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12651860	GOA
enables beta-catenin binding	IPI IPI: Inferred from physical interaction	29739711	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	10903890	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9824680	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	2105528	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of beta-catenin-TCF7L2 complex	IDA IDA: Inferred from direct assay	12651860	GOA
located in chromatin	IDA IDA: Inferred from direct assay	21880741	GOA
located in nucleus	IDA IDA: Inferred from direct assay	1681116	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TCF4 Protein Structure

HLH

0
200
400
600
667 a.a.

Protein Preferred Names

Protein Names

transcription factor 4

SL3-3 enhancer factor 2

TCF4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TCF4	P15884	INS	Homo sapiens	I3WAC9	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	INS	Homo sapiens	I3WAC9	Validated Y2H	25416956
Intra	TCF4	P15884	GOLGA8F	Homo sapiens	Q08AF8	Y2H Array	25416956
Intra	TCF4	P15884	EPHB6	Homo sapiens	O15197-2	Validated Y2H	25416956
Intra	TCF4	P15884	FERD3L	Homo sapiens	Q96RJ6	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	FERD3L	Homo sapiens	Q96RJ6	Y2H Array	25416956
Intra	TCF4	P15884	KCTD14	Homo sapiens	Q9BQ13	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	KCTD14	Homo sapiens	Q9BQ13	Validated Y2H	25416956
Intra	TCF4	P15884	CHAF1A	Homo sapiens	Q13111	Validated Y2H	25416956
Intra	TCF4	P15884	CHAF1A	Homo sapiens	Q13111	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	GNG10	Homo sapiens	P50151	Validated Y2H	25416956
Intra	TCF4	P15884	HAND2	Homo sapiens	P61296	Y2H Array	25416956
Intra	TCF4	P15884	RELA	Homo sapiens	Q04206-3	Y2H Array	25416956
Intra	TCF4	P15884	PTGER3	Homo sapiens	P43115-12	Validated Y2H	25416956
Intra	TCF4	P15884	TAL2	Homo sapiens	Q16559	Validated Y2H	25416956
Intra	TCF4	P15884	TAL2	Homo sapiens	Q16559	Y2H Array	25416956
Intra	TCF4	P15884	TAL2	Homo sapiens	Q16559	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	PLEKHN1	Homo sapiens	Q494U1	Y2H Array	31515488
Intra	TCF4	P15884	PLEKHN1	Homo sapiens	Q494U1	Validated Y2H	25416956
Intra	TCF4	P15884	PLEKHN1	Homo sapiens	Q494U1	Y2H Array	25416956
Intra	TCF4	P15884	q53fw8_human	Homo sapiens	Q53FW8	Validated Y2H	25416956
Intra	TCF4	P15884	q53fw8_human	Homo sapiens	Q53FW8	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	VPS28	Homo sapiens	Q548N1	Y2H Array	25416956
Intra	TCF4	P15884	RAB41	Homo sapiens	Q5JT25	Y2H Array	25416956
Intra	TCF4	P15884	SZT2	Homo sapiens	Q5T011-5	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	KLHL32	Homo sapiens	Q5THT1	Validated Y2H	25416956
Intra	TCF4	P15884	FAM74A4	Homo sapiens	Q5TZK3	Y2H Array	25416956
Intra	TCF4	P15884	NDOR1	Homo sapiens	Q9UHB4	Y2H Array	31515488
Intra	TCF4	P15884	NDOR1	Homo sapiens	Q9UHB4	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	NDOR1	Homo sapiens	Q9UHB4	Validated Y2H	25416956
Intra	TCF4	P15884	SFRS2	Homo sapiens	Q6NXQ0	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	ZDHHC24	Homo sapiens	Q6UX98	Y2H Array	25416956
Intra	TCF4	P15884	ZDHHC24	Homo sapiens	Q6UX98	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	ASCL4	Homo sapiens	Q6XD76	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	ASCL4	Homo sapiens	Q6XD76	Validated Y2H	25416956
Intra	TCF4	P15884	CFAP77	Homo sapiens	Q6ZQR2	Y2H Array	25416956
Intra	TCF4	P15884	CFAP77	Homo sapiens	Q6ZQR2	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	CFAP77	Homo sapiens	Q6ZQR2	Validated Y2H	25416956
Intra	TCF4	P15884	NR2C2AP	Homo sapiens	Q86WQ0	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	NR2C2AP	Homo sapiens	Q86WQ0	Y2H Array	25416956
Intra	TCF4	P15884	REXO1L1P	Homo sapiens	Q8IX06	Validated Y2H	25416956
Intra	TCF4	P15884	MORN4	Homo sapiens	Q8NDC4	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	MORN4	Homo sapiens	Q8NDC4	Validated Y2H	25416956
Intra	TCF4	P15884	LGALS14	Homo sapiens	Q8TCE9	Y2H Array	31515488
Intra	TCF4	P15884	LGALS14	Homo sapiens	Q8TCE9	Validated Y2H	25416956
Intra	TCF4	P15884	LGALS14	Homo sapiens	Q8TCE9	Y2H Array	25416956
Intra	TCF4	P15884	NEU4	Homo sapiens	Q8WWR8-2	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	PATE1	Homo sapiens	Q8WXA2	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	PATE1	Homo sapiens	Q8WXA2	Validated Y2H	25416956
Intra	TCF4	P15884	PATE1	Homo sapiens	Q8WXA2	Y2H Array	25416956
Intra	TCF4	P15884	NEUROG1	Homo sapiens	Q92886	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	NEUROG1	Homo sapiens	Q92886	Validated Y2H	25416956
Intra	TCF4	P15884	SLC39A13	Homo sapiens	Q96H72	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	NMUR2	Homo sapiens	Q9GZQ4	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	NMUR2	Homo sapiens	Q9GZQ4	Y2H Array	25416956
Intra	TCF4	P15884	TXNL4B	Homo sapiens	Q9NX01	Y2H Array	31515488
Intra	TCF4	P15884	TXNL4B	Homo sapiens	Q9NX01	Validated Y2H	25416956
Intra	TCF4	P15884	CABP5	Homo sapiens	Q9NP86	Y2H Array	29892012
Intra	TCF4	P15884	CABP5	Homo sapiens	Q9NP86	Y2H Array	31515488
Intra	TCF4	P15884	CABP5	Homo sapiens	Q9NP86	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	CABP5	Homo sapiens	Q9NP86	Validated Y2H	25416956
Intra	TCF4	P15884	SHFL	Homo sapiens	Q9NUL5	Validated Y2H	25416956
Intra	TCF4	P15884	SHFL	Homo sapiens	Q9NUL5	Y2H Array	25416956
Intra	TCF4	P15884	SEC14L4	Homo sapiens	Q9UDX3	Validated Y2H	25416956
Intra	TCF4	P15884	HEL-S-69p	Homo sapiens	V9HWF5	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	BCAS2	Homo sapiens	O75934	Validated Y2H	25416956
Intra	TCF4	P15884	BCAS2	Homo sapiens	O75934	Y2H Array	31515488
Intra	TCF4	P15884	BCAS2	Homo sapiens	O75934	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	BCAS2	Homo sapiens	O75934	Y2H Array	25416956
Intra	TCF4	P15884	OTUD4	Homo sapiens	Q01804	Validated Y2H	25416956
Intra	TCF4	P15884	POLR1C	Homo sapiens	O15160	Validated Y2H	25416956
Intra	TCF4	P15884	NOL9	Homo sapiens	Q5SY16	Y2H Array	25416956
Intra	TCF4	P15884	MEMO1	Homo sapiens	Q9Y316	Y2H Array	25416956
Intra	TCF4	P15884	MEMO1	Homo sapiens	Q9Y316	Validated Y2H	25416956
Intra	TCF4	P15884	ID1	Homo sapiens	P41134	Y2H	21988832
Intra	TCF4	P15884	ID1	Homo sapiens	P41134	Anti Tag CoIP	33961781
Intra	TCF4	P15884	ID1	Homo sapiens	P41134	TAP	25609649
Intra	TCF4	P15884	PRKAA2	Homo sapiens	P54646	Validated Y2H	25416956
Intra	TCF4	P15884	PRKAA2	Homo sapiens	P54646	Y2H Array	25416956
Intra	TCF4	P15884	ID3	Homo sapiens	Q02535	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	ID3	Homo sapiens	Q02535	Y2H Array	25416956
Intra	TCF4	P15884	ID3	Homo sapiens	Q02535	Anti Tag CoIP	33961781
Intra	TCF4	P15884	ID3	Homo sapiens	Q02535	Anti Tag CoIP	28514442
Intra	TCF4	P15884	ID3	Homo sapiens	Q02535	TAP	25609649
Intra	TCF4	P15884	KLC3	Homo sapiens	Q6P597	Y2H Array	25416956
Intra	TCF4	P15884	NEK8	Homo sapiens	Q86SG6	Y2H Array	25416956
Intra	TCF4	P15884	NEK8	Homo sapiens	Q86SG6	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	TAL1	Homo sapiens	P17542	Y2H	9824680
Intra	TCF4	P15884	TWIST1	Homo sapiens	Q15672	Anti Tag CoIP	33961781
Intra	TCF4	P15884	TWIST1	Homo sapiens	Q15672	Anti Tag CoIP	28514442
Intra	TCF4	P15884	TWIST1	Homo sapiens	Q15672	TAP	25609649
Intra	TCF4	P15884	TWIST2	Homo sapiens	Q8WVJ9	Y2H Array	25416956
Intra	TCF4	P15884	TWIST2	Homo sapiens	Q8WVJ9	Anti Tag CoIP	33961781
Intra	TCF4	P15884	TWIST2	Homo sapiens	Q8WVJ9	Anti Tag CoIP	28514442
Intra	TCF4	P15884	TWIST2	Homo sapiens	Q8WVJ9	Validated Y2H	25416956
Intra	TCF4	P15884	ASPSCR1	Homo sapiens	Q9BZE9	Validated Y2H	25416956
Intra	TCF4	P15884	ASPSCR1	Homo sapiens	Q9BZE9	Y2H Array	25416956
Intra	TCF4	P15884	SLC4A1AP	Homo sapiens	Q9BWU0	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	CHCHD2	Homo sapiens	Q9Y6H1	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	CHCHD2	Homo sapiens	Q9Y6H1	Validated Y2H	25416956
Intra	TCF4	P15884	HAT1	Homo sapiens	O14929	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	HAT1	Homo sapiens	O14929	Validated Y2H	25416956
Intra	TCF4	P15884	ZNF124	Homo sapiens	Q15973	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	ZNF124	Homo sapiens	Q15973	Validated Y2H	25416956
Intra	TCF4	P15884	ZNF124	Homo sapiens	Q15973	Y2H Array	25416956
Intra	TCF4	P15884	PPP1R18	Homo sapiens	Q6NYC8	Y2H Array	25416956
Intra	TCF4	P15884	PPIL1	Homo sapiens	Q9Y3C6	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	PPIL1	Homo sapiens	Q9Y3C6	Validated Y2H	25416956
Intra	TCF4	P15884	PPIL1	Homo sapiens	Q9Y3C6	Y2H Array	25416956
Intra	TCF4	P15884	PPIA	Homo sapiens	P62937-2	Validated Y2H	32814053
Intra	TCF4	P15884	PPIA	Homo sapiens	P62937-2	Y2H Pooling	32814053
Intra	TCF4	P15884	PPIA	Homo sapiens	P62937-2	Y2H Array	32814053
Intra	TCF4	P15884	SCOC	Homo sapiens	Q9UIL1	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	LMO4	Homo sapiens	P61968	Validated Y2H	25416956
Intra	TCF4	P15884	SMOC1	Homo sapiens	Q9H4F8	Validated Y2H	25416956
Intra	TCF4	P15884	SMOC1	Homo sapiens	Q9H4F8	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	LNPEP	Homo sapiens	Q9UIQ6	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	LNPEP	Homo sapiens	Q9UIQ6	Y2H Array	25416956
Intra	TCF4	P15884	MYO5B	Homo sapiens	Q9ULV0	Validated Y2H	25416956
Intra	TCF4	P15884	DDX6	Homo sapiens	P26196	Y2H Array	25416956
Intra	TCF4	P15884	DDX6	Homo sapiens	P26196	Validated Y2H	25416956
Intra	TCF4	P15884	XRCC6	Homo sapiens	P12956	Anti Bait CoIP	37207277
Intra	TCF4	P15884	CKB	Homo sapiens	P12277	Anti Bait CoIP	37207277
Intra	TCF4	P15884	XRCC5	Homo sapiens	P13010	Anti Bait CoIP	37207277
Intra	TCF4	P15884	PSMA1	Homo sapiens	P25786	Validated Y2H	25416956
Intra	TCF4	P15884	POLR1A	Homo sapiens	O95602	Validated Y2H	25416956
Intra	TCF4	P15884	POLR1A	Homo sapiens	O95602	Y2H Array	25416956
Intra	TCF4	P15884	YWHAG	Homo sapiens	P61981	Y2H Array	32814053
Intra	TCF4	P15884	YWHAG	Homo sapiens	P61981	Y2H Pooling	32814053
Intra	TCF4	P15884	YWHAG	Homo sapiens	P61981	Validated Y2H	32814053
Intra	TCF4	P15884	TP53	Homo sapiens	P04637	TAP	25609649
Intra	TCF4	P15884	EXOSC1	Homo sapiens	Q9Y3B2	Y2H Array	31515488
Intra	TCF4	P15884	EXOSC1	Homo sapiens	Q9Y3B2	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	SPATC1L	Homo sapiens	Q9H0A9	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	GLRX3	Homo sapiens	O76003	Y2H Array	25416956
Intra	TCF4	P15884	GLRX3	Homo sapiens	O76003	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	GLRX3	Homo sapiens	O76003	Validated Y2H	25416956
Intra	TCF4	P15884	ORC4	Homo sapiens	O43929	Validated Y2H	25416956
Intra	TCF4	P15884	CDKN1A	Homo sapiens	P38936	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	CDKN1A	Homo sapiens	P38936	Validated Y2H	25416956
Intra	TCF4	P15884	CDKN1A	Homo sapiens	P38936	Y2H Array	25416956
Intra	TCF4	P15884	TSSK3	Homo sapiens	Q96PN8	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	TSSK3	Homo sapiens	Q96PN8	Validated Y2H	25416956
Intra	TCF4	P15884	TSSK3	Homo sapiens	Q96PN8	Y2H Array	25416956
Intra	TCF4	P15884	KAT5	Homo sapiens	Q92993	Y2H Array	32814053
Intra	TCF4	P15884	KAT5	Homo sapiens	Q92993	Y2H Pooling	32814053
Intra	TCF4	P15884	KAT5	Homo sapiens	Q92993	Validated Y2H	32814053
Intra	TCF4	P15884	ATP6V1B2	Homo sapiens	P21281	Validated Y2H	25416956
Intra	TCF4	P15884	ATP6V1B2	Homo sapiens	P21281	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	FERMT2	Homo sapiens	Q96AC1	Anti Bait CoIP	22699938
Intra	TCF4	P15884	FERMT2	Homo sapiens	Q96AC1	Pull Down	22699938
Intra	TCF4	P15884	CKS1B	Homo sapiens	P61024	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	ARHGEF1	Homo sapiens	Q92888	Validated Y2H	25416956
Intra	TCF4	P15884	CTNNB1	Homo sapiens	P35222	Anti Bait CoIP	22699938
Intra	TCF4	P15884	CTNNB1	Homo sapiens	P35222	Pull Down	17875931
Intra	TCF4	P15884	CTNNB1	Homo sapiens	P35222	Anti Bait CoIP	21743491
Intra	TCF4	P15884	CTNNB1	Homo sapiens	P35222	Anti Bait CoIP	17318191
Intra	TCF4	P15884	CTNNB1	Homo sapiens	P35222	Anti Bait CoIP	21103407
Intra	TCF4	P15884	CTNNB1	Homo sapiens	P35222	Pull Down	22699938
Intra	TCF4	P15884	CTNNB1	Homo sapiens	P35222	Anti Bait CoIP	17983804
Intra	TCF4	P15884	UTP23	Homo sapiens	Q9BRU9	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	MLLT6	Homo sapiens	Q6P2C6	Y2H Prey Pooling	25416956
Cross	TCF4	P15884	Sox4	Mus musculus	Q06831	Pull Down	17875931
Intra	TCF4	P15884	MATN3	Homo sapiens	O15232	Y2H Array	25416956
Intra	TCF4	P15884	BCL2L2	Homo sapiens	Q92843	Y2H Array	25416956
Intra	TCF4	P15884	TCEA2	Homo sapiens	Q15560	Validated Y2H	25416956
Intra	TCF4	P15884	CDKN2C	Homo sapiens	P42773	Y2H Array	31515488
Intra	TCF4	P15884	ID2	Homo sapiens	Q02363	TAP	25609649
Intra	TCF4	P15884	NCK2	Homo sapiens	O43639	Validated Y2H	25416956
Intra	TCF4	P15884	NCK2	Homo sapiens	O43639	Y2H Array	25416956
Intra	TCF4	P15884	RABIF	Homo sapiens	P47224	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	RABIF	Homo sapiens	P47224	Y2H Array	25416956
Intra	TCF4	P15884	TLE5	Homo sapiens	Q08117	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	TLE5	Homo sapiens	Q08117	Validated Y2H	25416956
Intra	TCF4	P15884	PSMG2	Homo sapiens	Q969U7	Y2H Array	25416956
Intra	TCF4	P15884	MRPL10	Homo sapiens	Q7Z7H8	Validated Y2H	25416956
Intra	TCF4	P15884	MRPL10	Homo sapiens	Q7Z7H8	Y2H Array	25416956
Intra	TCF4	P15884	FRS3	Homo sapiens	O43559	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	FRS3	Homo sapiens	O43559	Validated Y2H	25416956
Intra	TCF4	P15884	LENG1	Homo sapiens	Q96BZ8	Validated Y2H	25416956
Intra	TCF4	P15884	LENG1	Homo sapiens	Q96BZ8	Y2H Array	25416956
Intra	TCF4	P15884	NUDT10	Homo sapiens	Q8NFP7	Validated Y2H	25416956
Intra	TCF4	P15884	HSPB7	Homo sapiens	Q9UBY9	Validated Y2H	25416956
Intra	TCF4	P15884	HSPB7	Homo sapiens	Q9UBY9	Y2H Array	25416956
Intra	TCF4	P15884	HSPB7	Homo sapiens	Q9UBY9	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	25416956
Intra	TCF4	P15884	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	29892012
Intra	TCF4	P15884	GORASP2	Homo sapiens	Q9H8Y8	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	25416956
Intra	TCF4	P15884	NEK6	Homo sapiens	Q9HC98	Y2H Array	25416956
Intra	TCF4	P15884	NEK6	Homo sapiens	Q9HC98	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	NEK6	Homo sapiens	Q9HC98	Y2H Array	29892012
Intra	TCF4	P15884	NEK6	Homo sapiens	Q9HC98	Validated Y2H	25416956
Intra	TCF4	P15884	ZNF417	Homo sapiens	Q8TAU3	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	ZNF417	Homo sapiens	Q8TAU3	Y2H Array	25416956
Intra	TCF4	P15884	EIF4EBP1	Homo sapiens	Q13541	Y2H Array	25416956
Intra	TCF4	P15884	CHIC2	Homo sapiens	Q9UKJ5	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	CHIC2	Homo sapiens	Q9UKJ5	Validated Y2H	25416956
Intra	TCF4	P15884	FAM124B	Homo sapiens	Q9H5Z6	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	FAM124B	Homo sapiens	Q9H5Z6	Validated Y2H	25416956
Intra	TCF4	P15884	FAM124B	Homo sapiens	Q9H5Z6	Y2H Array	25416956
Intra	TCF4	P15884	SPG21	Homo sapiens	Q9NZD8	Validated Y2H	25416956
Intra	TCF4	P15884	SPG21	Homo sapiens	Q9NZD8	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	LASP1	Homo sapiens	Q14847	Validated Y2H	25416956
Intra	TCF4	P15884	ARMC7	Homo sapiens	Q9H6L4	Validated Y2H	25416956
Intra	TCF4	P15884	EFHC1	Homo sapiens	Q5JVL4	Validated Y2H	25416956
Intra	TCF4	P15884	EFHC1	Homo sapiens	Q5JVL4	Y2H Array	31515488
Intra	TCF4	P15884	SGF29	Homo sapiens	Q96ES7	Anti Tag CoIP	33961781
Intra	TCF4	P15884	SGF29	Homo sapiens	Q96ES7	Anti Tag CoIP	28514442
Intra	TCF4	P15884	SGF29	Homo sapiens	Q96ES7	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	SGF29	Homo sapiens	Q96ES7	TAP	25609649
Intra	TCF4	P15884	NME7	Homo sapiens	Q9Y5B8	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	NME7	Homo sapiens	Q9Y5B8	Validated Y2H	25416956
Intra	TCF4	P15884	DEF6	Homo sapiens	Q9H4E7	Y2H Array	25416956
Intra	TCF4	P15884	DEF6	Homo sapiens	Q9H4E7	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	MAGOHB	Homo sapiens	Q96A72	Y2H Array	25416956
Intra	TCF4	P15884	TRAPPC2L	Homo sapiens	Q9UL33	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	RSPH14	Homo sapiens	Q9UHP6	Validated Y2H	25416956
Intra	TCF4	P15884	RSPH14	Homo sapiens	Q9UHP6	Y2H Array	25416956
Intra	TCF4	P15884	MRFAP1L1	Homo sapiens	Q96HT8	Validated Y2H	25416956
Intra	TCF4	P15884	MRFAP1L1	Homo sapiens	Q96HT8	Y2H Array	25416956
Intra	TCF4	P15884	STK16	Homo sapiens	O75716	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	STK16	Homo sapiens	O75716	Validated Y2H	25416956
Intra	TCF4	P15884	STK16	Homo sapiens	O75716	Y2H Array	25416956
Intra	TCF4	P15884	TCL1A	Homo sapiens	P56279	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	SMCP	Homo sapiens	P49901	Validated Y2H	25416956
Intra	TCF4	P15884	SMCP	Homo sapiens	P49901	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	PBLD	Homo sapiens	P30039	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	PBLD	Homo sapiens	P30039	Validated Y2H	25416956
Intra	TCF4	P15884	MAD2L2	Homo sapiens	Q9UI95	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	MAD2L2	Homo sapiens	Q9UI95	Y2H Array	25416956
Intra	TCF4	P15884	GUCD1	Homo sapiens	Q96NT3	Y2H Array	25416956
Intra	TCF4	P15884	GUCD1	Homo sapiens	Q96NT3	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	MSRB3	Homo sapiens	Q8IXL7	Validated Y2H	25416956
Intra	TCF4	P15884	LMO1	Homo sapiens	P25800	Y2H Array	25416956
Intra	TCF4	P15884	AIRIM	Homo sapiens	Q9NX04	Validated Y2H	25416956
Intra	TCF4	P15884	AIRIM	Homo sapiens	Q9NX04	Y2H Array	25416956
Intra	TCF4	P15884	AIRIM	Homo sapiens	Q9NX04	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	OSGIN1	Homo sapiens	Q9UJX0	Y2H Array	31515488
Intra	TCF4	P15884	OSGIN1	Homo sapiens	Q9UJX0	Validated Y2H	25416956
Intra	TCF4	P15884	SETDB1	Homo sapiens	Q15047-2	Y2H Pooling	32814053
Intra	TCF4	P15884	SETDB1	Homo sapiens	Q15047-2	Y2H Array	32814053
Intra	TCF4	P15884	SETDB1	Homo sapiens	Q15047-2	Validated Y2H	32814053
Cross	TCF4	P15884	Sox17	Mus musculus	Q61473	Pull Down	17875931
Intra	TCF4	P15884	MAPKBP1	Homo sapiens	O60336	Validated Y2H	25416956
Intra	TCF4	P15884	MAPKBP1	Homo sapiens	O60336	Y2H Array	25416956
Intra	TCF4	P15884	MAPKBP1	Homo sapiens	O60336	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	FLNA	Homo sapiens	P21333-2	Y2H Prey Pooling	25416956
Intra	TCF4	P15884	FLNA	Homo sapiens	P21333-2	Y2H Array	25416956
Intra	TCF4	P15884	DMRT3	Homo sapiens	Q9NQL9	Validated Y2H	25416956
Intra	TCF4	P15884	DMRT3	Homo sapiens	Q9NQL9	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

TCF4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83064	Transcription Factor 4 Antibody (YA2809)	WB, IHC-P, FC, ChIP	Human

Related Diseases

Diseases

Alias

Pitt-Hopkins Syndrome

PTHS	Encephalopathy, Severe Epileptic, With Autonomic Dysfunction
Mental Retardation, Syndromal, With Intermittent Hyperventilation	Intellectual Disability, Wide Mouth, Distinctive Facial Features, And Intermittent Hyperventilation Followed By Apnea
Pitt Hopkins Syndrome	Phs
Encephalopathy Severe Epileptic With Autonomic Dysfunction

Corneal Dystrophy, Fuchs Endothelial, 3

FECD3	Fcd2 Locus
Corneal Dystrophy, Fuchs Endothelial, Late-Onset	Fuchs Endothelial Corneal Dystrophy, Late-Onset
Dystrophy, Corneal, Fuchs Endothelial, Type 3

Fuchs' Endothelial Dystrophy

Fuchs Endothelial Corneal Dystrophy	Fuchs Endothelial Dystrophy
Fuchs Dystrophy	Fced
Fuchs' Corneal Dystrophy	Fuchs' Endothelial Corneal Dystrophy
Fuchs Atrophy	Fuchs Corneal Dystrophy
Endoepithelial Corneal Dystrophy	Fecd
Late Hereditary Endothelial Dystrophy	Corneal Dystrophy, Fuchs Endothelial
Dystrophy, Corneal, Fuchs Endothelial	Corneal Dystrophy, Fuchs' Endothelial, 1

Epicanthus

Motor Stereotypies

Motor Stereotypy

Stereotypic Movement Disorder

Stereotypy Habit Disorder	Stereotyped Repetitive Movements
Stereotyped Disorder	Stereotypes Nos
Stereotype Habit Disorder

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Autosomal Dominant Non-Syndromic Intellectual Disability

Cholangitis, Primary Sclerosing

Primary Sclerosing Cholangitis	PSC
Sclerosing Cholangitis	Cholangitis, Sclerosing
Cholangitis Primary Sclerosing	Psc - [Primary Sclerosing Cholangitis]

Corneal Dystrophy

Rett Syndrome

Atypical Rett Syndrome	RTT
Rett Disorder	Rts
Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use	Rett Syndrome, Preserved Speech Variant
Rett Syndrome, Atypical	Rett'S Disorder
Rett Syndrome Variant	Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome
Cerebroatrophic Hyperammonemia	Rett Like Syndrome
Rett'S Syndrome	Atypical Rtt
Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use	Rett Syndrome Preserved Speech Variant
Rett Syndrome Zappella Variant	Rett Syndrome, Zappella Variant

Intratubular Embryonal Carcinoma

Stage 0 Testicular Embryonal Carcinoma

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Thyroid Gland Mucoepidermoid Carcinoma

Mucoepidermoid Thyroid Carcinoma

Subacute Delirium

Delirium

Acute Confusional State Nos

Exudative Vitreoretinopathy 7

EVR7	Vitreoretinopathy, Exudative 7
Vitreoretinopathy Exudative, Type 7

Uterine Corpus Endometrial Carcinoma

Diencephalic Astrocytoma

Astrocytoma Of Diencephalon

Angelman Syndrome

AS	Happy Puppet Syndrome
Happy Puppet Syndrome, Formerly	Puppetlike Syndrome

Constipation

Corneal Dystrophy, Posterior Polymorphous, 2

Posterior Polymorphous Corneal Dystrophy 2	PPCD2
Corneal Dystrophy, Posterior Polymorphous 2	Corneal Dystrophy Polymorphous Posterior, 2
Dystrophy, Corneal, Posterior Polymorphous, Type 2

Deafness, X-Linked 2

Progressive Deafness With Stapes Fixation	DFNX2
Dfn3	Nance Deafness
Perilymphatic Gusher-Deafness Syndrome	Stapedo-Vestibular Ankylosis
Sensorineural Deafness, Profound, With Or Without A Conductive Component, Associated With A Unique Developmental Abnormality Of The Ear	X-Linked Deafness 2
X-Linked Mixed Conductive And Neurosensory Deafness	X-Linked Mixed Conductive And Sensorineural Deafness
Deafness 3 Conductive With Stapes Fixation	Deafness Conductive With Stapes Fixation
Deafness Mixed With Perilymphatic Gusher	Thies-Reis Syndrome
Deafness, Conductive, With Stapes Fixation	Deafness 3, Conductive, With Stapes Fixation
Deafness, Mixed, With Perilymphatic Gusher	Conductive Deafness 3 With Stapes Fixation
Conductive Deafness With Stapes Fixation	Mixed Deafness With Perilymphatic Gusher
X-Linked Deafness Type 2	X-Linked Mixed Conductive And Neurosensory Hearing Loss
X-Linked Mixed Conductive And Sensorineural Hearing Loss	X-Linked Sensorineural Deafness
X-Linked Stapes Gusher Syndrome	Deafness Mixed With Perilymphatic Gusher, X-Linked
Dfn 3 Nonsyndromic Hearing Loss And Deafness	Gusher Syndrome
Thies Reis Syndrome	Progressive Hearing Loss With Stapes Fixation
Deafness, X-Linked, 2	Deafness Mixed With Perilymph Gusher X-Linked
Deafness, X-Linked, Type 2	Progressive Hearing Loss Stapes Fixation

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Epididymis Adenocarcinoma

Adenocarcinoma Of The Epididymis

Epididymis Cancer

Malignant Tumor Of Epididymis	Malignant Epididymal Tumor
Malignant Neoplasm Of Epididymis	Neoplasm Of Epididymis

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B1360	Chlorquinaldol		99.47%	Unkown

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101486	LF3	Antagonist	99.55%	Unkown
HY-100760	Toxoflavin	Inhibitor	99.92%	Unkown
HY-P10392B	aStAx-35R TFA		99.18%	Unkown
HY-100760S	Toxoflavin-13C4	Inhibitor	/	Unkown
HY-124826	BC21	Inhibitor	/	Unkown
HY-149858	β-catenin-IN-7	Inhibitor	/	Unkown
HY-157126	Pterostilbene-isothiocyanate	Inhibitor	/	Unkown
HY-P10392	aStAx-35R		/	Unkown
HY-RS14307	TCF4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-119966	CCT036477	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TCF4	VGNC	VGNC:47197
Bos taurus	TCF4	VGNC	VGNC:35694
Macaca mulatta	TCF4	VGNC	VGNC:78288
Rattus norvegicus	TCF4	RGD	RGD:69271
Felis catus	TCF4	VGNC	VGNC:66027
Mus musculus	TCF4	MGD	MGI:98506
Others	TCF4	NCBI