2. Gene
  3. TCF4 - transcription factor 4 Gene

TCF4 - transcription factor 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as E2-2; ITF2; PTHS; SEF2; CDG2T; FECD3; ITF-2; SEF-2; TCF-4; SEF2-1; SEF2-1A; SEF2-1B; SEF2-1D; bHLHb19

Gene ID: 6925 | Gene type: protein coding

About TCF4

Cytogenetic location: 18q21.2 Genomic coordinates (GRCh38): 18:55,222,185-55,635,957 (from NCBI)

This gene has 93 transcripts (splice variants), 213 orthologues, 2 paralogues and is associated with 8 phenotypes. Ubiquitous expression in brain (RPKM 17.0), fat (RPKM 14.9) and 24 other tissues.

Summary

This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. In addition, an intronic CTG repeat normally numbering 10-37 repeat units can expand to >50 repeat units and cause Fuchs endothelial corneal dystrophy. Multiple alternatively spliced transcript variants that encode different proteins have been described. [provided by RefSeq, Jul 2016]

TCF4 Products(46)

mRNA Protein Name
NM_001083962.2 NP_001077431.1 transcription factor 4 isoform a
NM_001243226.3 NP_001230155.2 transcription factor 4 isoform c
NM_001243227.2 NP_001230156.1 transcription factor 4 isoform d
NM_001243228.2 NP_001230157.1 transcription factor 4 isoform e
NM_001243230.2 NP_001230159.1 transcription factor 4 isoform f
NM_001243231.2 NP_001230160.1 transcription factor 4 isoform g
NM_001243232.1 NP_001230161.1 transcription factor 4 isoform h
NM_001243233.2 NP_001230162.1 transcription factor 4 isoform i
NM_001243234.2 NP_001230163.1 transcription factor 4 isoform j
NM_001243235.2 NP_001230164.1 transcription factor 4 isoform k
NM_001243236.2 NP_001230165.1 transcription factor 4 isoform l
NM_001306207.1 NP_001293136.1 transcription factor 4 isoform m
NM_001306208.1 NP_001293137.1 transcription factor 4 isoform n
NM_001330604.3 NP_001317533.1 transcription factor 4 isoform o
NM_001330605.3 NP_001317534.1 transcription factor 4 isoform p
NM_001348211.2 NP_001335140.1 transcription factor 4 isoform q
NM_001348212.2 NP_001335141.1 transcription factor 4 isoform i
NM_001348213.2 NP_001335142.1 transcription factor 4 isoform p
NM_001348214.2 NP_001335143.1 transcription factor 4 isoform r
NM_001348215.2 NP_001335144.1 transcription factor 4 isoform s
NM_001348216.2 NP_001335145.1 transcription factor 4 isoform t
NM_001348217.1 NP_001335146.1 transcription factor 4 isoform d
NM_001348218.2 NP_001335147.1 transcription factor 4 isoform d
NM_001348219.2 NP_001335148.1 transcription factor 4 isoform m
NM_001348220.1 NP_001335149.1 transcription factor 4 isoform u
NM_001369567.1 NP_001356496.1 transcription factor 4 isoform a
NM_001369568.1 NP_001356497.1 transcription factor 4 isoform a
NM_001369569.1 NP_001356498.1 transcription factor 4 isoform v
NM_001369570.1 NP_001356499.1 transcription factor 4 isoform v
NM_001369571.1 NP_001356500.1 transcription factor 4 isoform b
NM_001369572.1 NP_001356501.1 transcription factor 4 isoform b
NM_001369573.1 NP_001356502.1 transcription factor 4 isoform x
NM_001369574.1 NP_001356503.1 transcription factor 4 isoform 27
NM_001369575.1 NP_001356504.1 transcription factor 4 isoform d
NM_001369576.1 NP_001356505.1 transcription factor 4 isoform y
NM_001369577.1 NP_001356506.1 transcription factor 4 isoform 28
NM_001369578.1 NP_001356507.1 transcription factor 4 isoform y
NM_001369579.1 NP_001356508.1 transcription factor 4 isoform 28
NM_001369580.1 NP_001356509.1 transcription factor 4 isoform 28
NM_001369581.1 NP_001356510.1 transcription factor 4 isoform y
NM_001369582.1 NP_001356511.1 transcription factor 4 isoform m
NM_001369583.1 NP_001356512.1 transcription factor 4 isoform m
NM_001369584.1 NP_001356513.1 transcription factor 4 isoform u
NM_001369585.1 NP_001356514.1 transcription factor 4 isoform u
NM_001369586.1 NP_001356515.1 transcription factor 4 isoform z
NM_003199.3 NP_003190.1 transcription factor 4 isoform b
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA binding IDA
IDA: Inferred from direct assay
1681116 GOA
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
2105528 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
12651860 GOA
enables beta-catenin binding IPI
IPI: Inferred from physical interaction
29739711 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
10903890 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9824680 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
2105528 GOA
Cellular Component GO Annotation Evidence Reference Source
part of beta-catenin-TCF7L2 complex IDA
IDA: Inferred from direct assay
12651860 GOA
located in chromatin IDA
IDA: Inferred from direct assay
21880741 GOA
located in nucleus IDA
IDA: Inferred from direct assay
1681116 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TCF4 Protein Structure

HLH

HLH: Helix-loop-helix DNA-binding domain (565 - 618)

  • 0
  • 200
  • 400
  • 600
  • 667 a.a.
Protein Preferred Names Protein Names

transcription factor 4

SL3-3 enhancer factor 2

TCF4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
TCF4 P15884 INS Homo sapiens I3WAC9
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 INS Homo sapiens I3WAC9
Validated Y2H
25416956
Intra
TCF4 P15884 GOLGA8F Homo sapiens Q08AF8
Y2H Array
25416956
Intra
TCF4 P15884 EPHB6 Homo sapiens O15197-2
Validated Y2H
25416956
Intra
TCF4 P15884 FERD3L Homo sapiens Q96RJ6
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 FERD3L Homo sapiens Q96RJ6
Y2H Array
25416956
Intra
TCF4 P15884 KCTD14 Homo sapiens Q9BQ13
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 KCTD14 Homo sapiens Q9BQ13
Validated Y2H
25416956
Intra
TCF4 P15884 CHAF1A Homo sapiens Q13111
Validated Y2H
25416956
Intra
TCF4 P15884 CHAF1A Homo sapiens Q13111
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 GNG10 Homo sapiens P50151
Validated Y2H
25416956
Intra
TCF4 P15884 HAND2 Homo sapiens P61296
Y2H Array
25416956
Intra
TCF4 P15884 RELA Homo sapiens Q04206-3
Y2H Array
25416956
Intra
TCF4 P15884 PTGER3 Homo sapiens P43115-12
Validated Y2H
25416956
Intra
TCF4 P15884 TAL2 Homo sapiens Q16559
Validated Y2H
25416956
Intra
TCF4 P15884 TAL2 Homo sapiens Q16559
Y2H Array
25416956
Intra
TCF4 P15884 TAL2 Homo sapiens Q16559
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 PLEKHN1 Homo sapiens Q494U1
Y2H Array
31515488
Intra
TCF4 P15884 PLEKHN1 Homo sapiens Q494U1
Validated Y2H
25416956
Intra
TCF4 P15884 PLEKHN1 Homo sapiens Q494U1
Y2H Array
25416956
Intra
TCF4 P15884 q53fw8_human Homo sapiens Q53FW8
Validated Y2H
25416956
Intra
TCF4 P15884 q53fw8_human Homo sapiens Q53FW8
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 VPS28 Homo sapiens Q548N1
Y2H Array
25416956
Intra
TCF4 P15884 RAB41 Homo sapiens Q5JT25
Y2H Array
25416956
Intra
TCF4 P15884 SZT2 Homo sapiens Q5T011-5
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 KLHL32 Homo sapiens Q5THT1
Validated Y2H
25416956
Intra
TCF4 P15884 FAM74A4 Homo sapiens Q5TZK3
Y2H Array
25416956
Intra
TCF4 P15884 NDOR1 Homo sapiens Q9UHB4
Y2H Array
31515488
Intra
TCF4 P15884 NDOR1 Homo sapiens Q9UHB4
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 NDOR1 Homo sapiens Q9UHB4
Validated Y2H
25416956
Intra
TCF4 P15884 SFRS2 Homo sapiens Q6NXQ0
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 ZDHHC24 Homo sapiens Q6UX98
Y2H Array
25416956
Intra
TCF4 P15884 ZDHHC24 Homo sapiens Q6UX98
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 ASCL4 Homo sapiens Q6XD76
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 ASCL4 Homo sapiens Q6XD76
Validated Y2H
25416956
Intra
TCF4 P15884 CFAP77 Homo sapiens Q6ZQR2
Y2H Array
25416956
Intra
TCF4 P15884 CFAP77 Homo sapiens Q6ZQR2
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 CFAP77 Homo sapiens Q6ZQR2
Validated Y2H
25416956
Intra
TCF4 P15884 NR2C2AP Homo sapiens Q86WQ0
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 NR2C2AP Homo sapiens Q86WQ0
Y2H Array
25416956
Intra
TCF4 P15884 REXO1L1P Homo sapiens Q8IX06
Validated Y2H
25416956
Intra
TCF4 P15884 MORN4 Homo sapiens Q8NDC4
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 MORN4 Homo sapiens Q8NDC4
Validated Y2H
25416956
Intra
TCF4 P15884 LGALS14 Homo sapiens Q8TCE9
Y2H Array
31515488
Intra
TCF4 P15884 LGALS14 Homo sapiens Q8TCE9
Validated Y2H
25416956
Intra
TCF4 P15884 LGALS14 Homo sapiens Q8TCE9
Y2H Array
25416956
Intra
TCF4 P15884 NEU4 Homo sapiens Q8WWR8-2
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 PATE1 Homo sapiens Q8WXA2
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 PATE1 Homo sapiens Q8WXA2
Validated Y2H
25416956
Intra
TCF4 P15884 PATE1 Homo sapiens Q8WXA2
Y2H Array
25416956
Intra
TCF4 P15884 NEUROG1 Homo sapiens Q92886
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 NEUROG1 Homo sapiens Q92886
Validated Y2H
25416956
Intra
TCF4 P15884 SLC39A13 Homo sapiens Q96H72
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 NMUR2 Homo sapiens Q9GZQ4
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 NMUR2 Homo sapiens Q9GZQ4
Y2H Array
25416956
Intra
TCF4 P15884 TXNL4B Homo sapiens Q9NX01
Y2H Array
31515488
Intra
TCF4 P15884 TXNL4B Homo sapiens Q9NX01
Validated Y2H
25416956
Intra
TCF4 P15884 CABP5 Homo sapiens Q9NP86
Y2H Array
29892012
Intra
TCF4 P15884 CABP5 Homo sapiens Q9NP86
Y2H Array
31515488
Intra
TCF4 P15884 CABP5 Homo sapiens Q9NP86
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 CABP5 Homo sapiens Q9NP86
Validated Y2H
25416956
Intra
TCF4 P15884 SHFL Homo sapiens Q9NUL5
Validated Y2H
25416956
Intra
TCF4 P15884 SHFL Homo sapiens Q9NUL5
Y2H Array
25416956
Intra
TCF4 P15884 SEC14L4 Homo sapiens Q9UDX3
Validated Y2H
25416956
Intra
TCF4 P15884 HEL-S-69p Homo sapiens V9HWF5
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 BCAS2 Homo sapiens O75934
Validated Y2H
25416956
Intra
TCF4 P15884 BCAS2 Homo sapiens O75934
Y2H Array
31515488
Intra
TCF4 P15884 BCAS2 Homo sapiens O75934
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 BCAS2 Homo sapiens O75934
Y2H Array
25416956
Intra
TCF4 P15884 OTUD4 Homo sapiens Q01804
Validated Y2H
25416956
Intra
TCF4 P15884 POLR1C Homo sapiens O15160
Validated Y2H
25416956
Intra
TCF4 P15884 NOL9 Homo sapiens Q5SY16
Y2H Array
25416956
Intra
TCF4 P15884 MEMO1 Homo sapiens Q9Y316
Y2H Array
25416956
Intra
TCF4 P15884 MEMO1 Homo sapiens Q9Y316
Validated Y2H
25416956
Intra
TCF4 P15884 ID1 Homo sapiens P41134
Y2H
21988832
Intra
TCF4 P15884 ID1 Homo sapiens P41134
Anti Tag CoIP
33961781
Intra
TCF4 P15884 ID1 Homo sapiens P41134
TAP
25609649
Intra
TCF4 P15884 PRKAA2 Homo sapiens P54646
Validated Y2H
25416956
Intra
TCF4 P15884 PRKAA2 Homo sapiens P54646
Y2H Array
25416956
Intra
TCF4 P15884 ID3 Homo sapiens Q02535
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 ID3 Homo sapiens Q02535
Y2H Array
25416956
Intra
TCF4 P15884 ID3 Homo sapiens Q02535
Anti Tag CoIP
33961781
Intra
TCF4 P15884 ID3 Homo sapiens Q02535
Anti Tag CoIP
28514442
Intra
TCF4 P15884 ID3 Homo sapiens Q02535
TAP
25609649
Intra
TCF4 P15884 KLC3 Homo sapiens Q6P597
Y2H Array
25416956
Intra
TCF4 P15884 NEK8 Homo sapiens Q86SG6
Y2H Array
25416956
Intra
TCF4 P15884 NEK8 Homo sapiens Q86SG6
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 TAL1 Homo sapiens P17542
Y2H
9824680
Intra
TCF4 P15884 TWIST1 Homo sapiens Q15672
Anti Tag CoIP
33961781
Intra
TCF4 P15884 TWIST1 Homo sapiens Q15672
Anti Tag CoIP
28514442
Intra
TCF4 P15884 TWIST1 Homo sapiens Q15672
TAP
25609649
Intra
TCF4 P15884 TWIST2 Homo sapiens Q8WVJ9
Y2H Array
25416956
Intra
TCF4 P15884 TWIST2 Homo sapiens Q8WVJ9
Anti Tag CoIP
33961781
Intra
TCF4 P15884 TWIST2 Homo sapiens Q8WVJ9
Anti Tag CoIP
28514442
Intra
TCF4 P15884 TWIST2 Homo sapiens Q8WVJ9
Validated Y2H
25416956
Intra
TCF4 P15884 ASPSCR1 Homo sapiens Q9BZE9
Validated Y2H
25416956
Intra
TCF4 P15884 ASPSCR1 Homo sapiens Q9BZE9
Y2H Array
25416956
Intra
TCF4 P15884 SLC4A1AP Homo sapiens Q9BWU0
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 CHCHD2 Homo sapiens Q9Y6H1
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 CHCHD2 Homo sapiens Q9Y6H1
Validated Y2H
25416956
Intra
TCF4 P15884 HAT1 Homo sapiens O14929
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 HAT1 Homo sapiens O14929
Validated Y2H
25416956
Intra
TCF4 P15884 ZNF124 Homo sapiens Q15973
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 ZNF124 Homo sapiens Q15973
Validated Y2H
25416956
Intra
TCF4 P15884 ZNF124 Homo sapiens Q15973
Y2H Array
25416956
Intra
TCF4 P15884 PPP1R18 Homo sapiens Q6NYC8
Y2H Array
25416956
Intra
TCF4 P15884 PPIL1 Homo sapiens Q9Y3C6
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 PPIL1 Homo sapiens Q9Y3C6
Validated Y2H
25416956
Intra
TCF4 P15884 PPIL1 Homo sapiens Q9Y3C6
Y2H Array
25416956
Intra
TCF4 P15884 PPIA Homo sapiens P62937-2
Validated Y2H
32814053
Intra
TCF4 P15884 PPIA Homo sapiens P62937-2
Y2H Pooling
32814053
Intra
TCF4 P15884 PPIA Homo sapiens P62937-2
Y2H Array
32814053
Intra
TCF4 P15884 SCOC Homo sapiens Q9UIL1
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 LMO4 Homo sapiens P61968
Validated Y2H
25416956
Intra
TCF4 P15884 SMOC1 Homo sapiens Q9H4F8
Validated Y2H
25416956
Intra
TCF4 P15884 SMOC1 Homo sapiens Q9H4F8
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 LNPEP Homo sapiens Q9UIQ6
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 LNPEP Homo sapiens Q9UIQ6
Y2H Array
25416956
Intra
TCF4 P15884 MYO5B Homo sapiens Q9ULV0
Validated Y2H
25416956
Intra
TCF4 P15884 DDX6 Homo sapiens P26196
Y2H Array
25416956
Intra
TCF4 P15884 DDX6 Homo sapiens P26196
Validated Y2H
25416956
Intra
TCF4 P15884 XRCC6 Homo sapiens P12956
Anti Bait CoIP
37207277
Intra
TCF4 P15884 CKB Homo sapiens P12277
Anti Bait CoIP
37207277
Intra
TCF4 P15884 XRCC5 Homo sapiens P13010
Anti Bait CoIP
37207277
Intra
TCF4 P15884 PSMA1 Homo sapiens P25786
Validated Y2H
25416956
Intra
TCF4 P15884 POLR1A Homo sapiens O95602
Validated Y2H
25416956
Intra
TCF4 P15884 POLR1A Homo sapiens O95602
Y2H Array
25416956
Intra
TCF4 P15884 YWHAG Homo sapiens P61981
Y2H Array
32814053
Intra
TCF4 P15884 YWHAG Homo sapiens P61981
Y2H Pooling
32814053
Intra
TCF4 P15884 YWHAG Homo sapiens P61981
Validated Y2H
32814053
Intra
TCF4 P15884 TP53 Homo sapiens P04637
TAP
25609649
Intra
TCF4 P15884 EXOSC1 Homo sapiens Q9Y3B2
Y2H Array
31515488
Intra
TCF4 P15884 EXOSC1 Homo sapiens Q9Y3B2
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 SPATC1L Homo sapiens Q9H0A9
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 GLRX3 Homo sapiens O76003
Y2H Array
25416956
Intra
TCF4 P15884 GLRX3 Homo sapiens O76003
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 GLRX3 Homo sapiens O76003
Validated Y2H
25416956
Intra
TCF4 P15884 ORC4 Homo sapiens O43929
Validated Y2H
25416956
Intra
TCF4 P15884 CDKN1A Homo sapiens P38936
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 CDKN1A Homo sapiens P38936
Validated Y2H
25416956
Intra
TCF4 P15884 CDKN1A Homo sapiens P38936
Y2H Array
25416956
Intra
TCF4 P15884 TSSK3 Homo sapiens Q96PN8
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 TSSK3 Homo sapiens Q96PN8
Validated Y2H
25416956
Intra
TCF4 P15884 TSSK3 Homo sapiens Q96PN8
Y2H Array
25416956
Intra
TCF4 P15884 KAT5 Homo sapiens Q92993
Y2H Array
32814053
Intra
TCF4 P15884 KAT5 Homo sapiens Q92993
Y2H Pooling
32814053
Intra
TCF4 P15884 KAT5 Homo sapiens Q92993
Validated Y2H
32814053
Intra
TCF4 P15884 ATP6V1B2 Homo sapiens P21281
Validated Y2H
25416956
Intra
TCF4 P15884 ATP6V1B2 Homo sapiens P21281
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 FERMT2 Homo sapiens Q96AC1
Anti Bait CoIP
22699938
Intra
TCF4 P15884 FERMT2 Homo sapiens Q96AC1
Pull Down
22699938
Intra
TCF4 P15884 CKS1B Homo sapiens P61024
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 ARHGEF1 Homo sapiens Q92888
Validated Y2H
25416956
Intra
TCF4 P15884 CTNNB1 Homo sapiens P35222
Anti Bait CoIP
22699938
Intra
TCF4 P15884 CTNNB1 Homo sapiens P35222
Pull Down
17875931
Intra
TCF4 P15884 CTNNB1 Homo sapiens P35222
Anti Bait CoIP
21743491
Intra
TCF4 P15884 CTNNB1 Homo sapiens P35222
Anti Bait CoIP
17318191
Intra
TCF4 P15884 CTNNB1 Homo sapiens P35222
Anti Bait CoIP
21103407
Intra
TCF4 P15884 CTNNB1 Homo sapiens P35222
Pull Down
22699938
Intra
TCF4 P15884 CTNNB1 Homo sapiens P35222
Anti Bait CoIP
17983804
Intra
TCF4 P15884 UTP23 Homo sapiens Q9BRU9
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 MLLT6 Homo sapiens Q6P2C6
Y2H Prey Pooling
25416956
Cross
TCF4 P15884 Sox4 Mus musculus Q06831
Pull Down
17875931
Intra
TCF4 P15884 MATN3 Homo sapiens O15232
Y2H Array
25416956
Intra
TCF4 P15884 BCL2L2 Homo sapiens Q92843
Y2H Array
25416956
Intra
TCF4 P15884 TCEA2 Homo sapiens Q15560
Validated Y2H
25416956
Intra
TCF4 P15884 CDKN2C Homo sapiens P42773
Y2H Array
31515488
Intra
TCF4 P15884 ID2 Homo sapiens Q02363
TAP
25609649
Intra
TCF4 P15884 NCK2 Homo sapiens O43639
Validated Y2H
25416956
Intra
TCF4 P15884 NCK2 Homo sapiens O43639
Y2H Array
25416956
Intra
TCF4 P15884 RABIF Homo sapiens P47224
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 RABIF Homo sapiens P47224
Y2H Array
25416956
Intra
TCF4 P15884 TLE5 Homo sapiens Q08117
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 TLE5 Homo sapiens Q08117
Validated Y2H
25416956
Intra
TCF4 P15884 PSMG2 Homo sapiens Q969U7
Y2H Array
25416956
Intra
TCF4 P15884 MRPL10 Homo sapiens Q7Z7H8
Validated Y2H
25416956
Intra
TCF4 P15884 MRPL10 Homo sapiens Q7Z7H8
Y2H Array
25416956
Intra
TCF4 P15884 FRS3 Homo sapiens O43559
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 FRS3 Homo sapiens O43559
Validated Y2H
25416956
Intra
TCF4 P15884 LENG1 Homo sapiens Q96BZ8
Validated Y2H
25416956
Intra
TCF4 P15884 LENG1 Homo sapiens Q96BZ8
Y2H Array
25416956
Intra
TCF4 P15884 NUDT10 Homo sapiens Q8NFP7
Validated Y2H
25416956
Intra
TCF4 P15884 HSPB7 Homo sapiens Q9UBY9
Validated Y2H
25416956
Intra
TCF4 P15884 HSPB7 Homo sapiens Q9UBY9
Y2H Array
25416956
Intra
TCF4 P15884 HSPB7 Homo sapiens Q9UBY9
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 GORASP2 Homo sapiens Q9H8Y8
Validated Y2H
25416956
Intra
TCF4 P15884 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
29892012
Intra
TCF4 P15884 GORASP2 Homo sapiens Q9H8Y8
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
25416956
Intra
TCF4 P15884 NEK6 Homo sapiens Q9HC98
Y2H Array
25416956
Intra
TCF4 P15884 NEK6 Homo sapiens Q9HC98
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 NEK6 Homo sapiens Q9HC98
Y2H Array
29892012
Intra
TCF4 P15884 NEK6 Homo sapiens Q9HC98
Validated Y2H
25416956
Intra
TCF4 P15884 ZNF417 Homo sapiens Q8TAU3
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 ZNF417 Homo sapiens Q8TAU3
Y2H Array
25416956
Intra
TCF4 P15884 EIF4EBP1 Homo sapiens Q13541
Y2H Array
25416956
Intra
TCF4 P15884 CHIC2 Homo sapiens Q9UKJ5
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 CHIC2 Homo sapiens Q9UKJ5
Validated Y2H
25416956
Intra
TCF4 P15884 FAM124B Homo sapiens Q9H5Z6
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 FAM124B Homo sapiens Q9H5Z6
Validated Y2H
25416956
Intra
TCF4 P15884 FAM124B Homo sapiens Q9H5Z6
Y2H Array
25416956
Intra
TCF4 P15884 SPG21 Homo sapiens Q9NZD8
Validated Y2H
25416956
Intra
TCF4 P15884 SPG21 Homo sapiens Q9NZD8
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 LASP1 Homo sapiens Q14847
Validated Y2H
25416956
Intra
TCF4 P15884 ARMC7 Homo sapiens Q9H6L4
Validated Y2H
25416956
Intra
TCF4 P15884 EFHC1 Homo sapiens Q5JVL4
Validated Y2H
25416956
Intra
TCF4 P15884 EFHC1 Homo sapiens Q5JVL4
Y2H Array
31515488
Intra
TCF4 P15884 SGF29 Homo sapiens Q96ES7
Anti Tag CoIP
33961781
Intra
TCF4 P15884 SGF29 Homo sapiens Q96ES7
Anti Tag CoIP
28514442
Intra
TCF4 P15884 SGF29 Homo sapiens Q96ES7
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 SGF29 Homo sapiens Q96ES7
TAP
25609649
Intra
TCF4 P15884 NME7 Homo sapiens Q9Y5B8
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 NME7 Homo sapiens Q9Y5B8
Validated Y2H
25416956
Intra
TCF4 P15884 DEF6 Homo sapiens Q9H4E7
Y2H Array
25416956
Intra
TCF4 P15884 DEF6 Homo sapiens Q9H4E7
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 MAGOHB Homo sapiens Q96A72
Y2H Array
25416956
Intra
TCF4 P15884 TRAPPC2L Homo sapiens Q9UL33
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 RSPH14 Homo sapiens Q9UHP6
Validated Y2H
25416956
Intra
TCF4 P15884 RSPH14 Homo sapiens Q9UHP6
Y2H Array
25416956
Intra
TCF4 P15884 MRFAP1L1 Homo sapiens Q96HT8
Validated Y2H
25416956
Intra
TCF4 P15884 MRFAP1L1 Homo sapiens Q96HT8
Y2H Array
25416956
Intra
TCF4 P15884 STK16 Homo sapiens O75716
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 STK16 Homo sapiens O75716
Validated Y2H
25416956
Intra
TCF4 P15884 STK16 Homo sapiens O75716
Y2H Array
25416956
Intra
TCF4 P15884 TCL1A Homo sapiens P56279
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 SMCP Homo sapiens P49901
Validated Y2H
25416956
Intra
TCF4 P15884 SMCP Homo sapiens P49901
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 PBLD Homo sapiens P30039
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 PBLD Homo sapiens P30039
Validated Y2H
25416956
Intra
TCF4 P15884 MAD2L2 Homo sapiens Q9UI95
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 MAD2L2 Homo sapiens Q9UI95
Y2H Array
25416956
Intra
TCF4 P15884 GUCD1 Homo sapiens Q96NT3
Y2H Array
25416956
Intra
TCF4 P15884 GUCD1 Homo sapiens Q96NT3
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 MSRB3 Homo sapiens Q8IXL7
Validated Y2H
25416956
Intra
TCF4 P15884 LMO1 Homo sapiens P25800
Y2H Array
25416956
Intra
TCF4 P15884 AIRIM Homo sapiens Q9NX04
Validated Y2H
25416956
Intra
TCF4 P15884 AIRIM Homo sapiens Q9NX04
Y2H Array
25416956
Intra
TCF4 P15884 AIRIM Homo sapiens Q9NX04
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 OSGIN1 Homo sapiens Q9UJX0
Y2H Array
31515488
Intra
TCF4 P15884 OSGIN1 Homo sapiens Q9UJX0
Validated Y2H
25416956
Intra
TCF4 P15884 SETDB1 Homo sapiens Q15047-2
Y2H Pooling
32814053
Intra
TCF4 P15884 SETDB1 Homo sapiens Q15047-2
Y2H Array
32814053
Intra
TCF4 P15884 SETDB1 Homo sapiens Q15047-2
Validated Y2H
32814053
Cross
TCF4 P15884 Sox17 Mus musculus Q61473
Pull Down
17875931
Intra
TCF4 P15884 MAPKBP1 Homo sapiens O60336
Validated Y2H
25416956
Intra
TCF4 P15884 MAPKBP1 Homo sapiens O60336
Y2H Array
25416956
Intra
TCF4 P15884 MAPKBP1 Homo sapiens O60336
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 FLNA Homo sapiens P21333-2
Y2H Prey Pooling
25416956
Intra
TCF4 P15884 FLNA Homo sapiens P21333-2
Y2H Array
25416956
Intra
TCF4 P15884 DMRT3 Homo sapiens Q9NQL9
Validated Y2H
25416956
Intra
TCF4 P15884 DMRT3 Homo sapiens Q9NQL9
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Pitt-Hopkins Syndrome

PTHS

Encephalopathy, Severe Epileptic, With Autonomic Dysfunction

Mental Retardation, Syndromal, With Intermittent Hyperventilation

Intellectual Disability, Wide Mouth, Distinctive Facial Features, And Intermittent Hyperventilation Followed By Apnea

Pitt Hopkins Syndrome

Phs

Encephalopathy Severe Epileptic With Autonomic Dysfunction
Corneal Dystrophy, Fuchs Endothelial, 3

FECD3

Fcd2 Locus

Corneal Dystrophy, Fuchs Endothelial, Late-Onset

Fuchs Endothelial Corneal Dystrophy, Late-Onset

Dystrophy, Corneal, Fuchs Endothelial, Type 3
Fuchs' Endothelial Dystrophy

Fuchs Endothelial Corneal Dystrophy

Fuchs Endothelial Dystrophy

Fuchs Dystrophy

Fced

Fuchs' Corneal Dystrophy

Fuchs' Endothelial Corneal Dystrophy

Fuchs Atrophy

Fuchs Corneal Dystrophy

Endoepithelial Corneal Dystrophy

Fecd

Late Hereditary Endothelial Dystrophy

Corneal Dystrophy, Fuchs Endothelial

Dystrophy, Corneal, Fuchs Endothelial

Corneal Dystrophy, Fuchs' Endothelial, 1
Epicanthus
Motor Stereotypies

Motor Stereotypy
Stereotypic Movement Disorder

Stereotypy Habit Disorder

Stereotyped Repetitive Movements

Stereotyped Disorder

Stereotypes Nos

Stereotype Habit Disorder
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Autosomal Dominant Non-Syndromic Intellectual Disability
Cholangitis, Primary Sclerosing

Primary Sclerosing Cholangitis

PSC

Sclerosing Cholangitis

Cholangitis, Sclerosing

Cholangitis Primary Sclerosing

Psc - [Primary Sclerosing Cholangitis]
Corneal Dystrophy
Rett Syndrome

Atypical Rett Syndrome

RTT

Rett Disorder

Rts

Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use

Rett Syndrome, Preserved Speech Variant

Rett Syndrome, Atypical

Rett'S Disorder

Rett Syndrome Variant

Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome

Cerebroatrophic Hyperammonemia

Rett Like Syndrome

Rett'S Syndrome

Atypical Rtt

Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use

Rett Syndrome Preserved Speech Variant

Rett Syndrome Zappella Variant

Rett Syndrome, Zappella Variant
Intratubular Embryonal Carcinoma

Stage 0 Testicular Embryonal Carcinoma
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Thyroid Gland Mucoepidermoid Carcinoma

Mucoepidermoid Thyroid Carcinoma
Subacute Delirium

Delirium

Acute Confusional State Nos
Exudative Vitreoretinopathy 7

EVR7

Vitreoretinopathy, Exudative 7

Vitreoretinopathy Exudative, Type 7
Uterine Corpus Endometrial Carcinoma
Diencephalic Astrocytoma

Astrocytoma Of Diencephalon
Angelman Syndrome

AS

Happy Puppet Syndrome

Happy Puppet Syndrome, Formerly

Puppetlike Syndrome
Constipation
Corneal Dystrophy, Posterior Polymorphous, 2

Posterior Polymorphous Corneal Dystrophy 2

PPCD2

Corneal Dystrophy, Posterior Polymorphous 2

Corneal Dystrophy Polymorphous Posterior, 2

Dystrophy, Corneal, Posterior Polymorphous, Type 2
Deafness, X-Linked 2

Progressive Deafness With Stapes Fixation

DFNX2

Dfn3

Nance Deafness

Perilymphatic Gusher-Deafness Syndrome

Stapedo-Vestibular Ankylosis

Sensorineural Deafness, Profound, With Or Without A Conductive Component, Associated With A Unique Developmental Abnormality Of The Ear

X-Linked Deafness 2

X-Linked Mixed Conductive And Neurosensory Deafness

X-Linked Mixed Conductive And Sensorineural Deafness

Deafness 3 Conductive With Stapes Fixation

Deafness Conductive With Stapes Fixation

Deafness Mixed With Perilymphatic Gusher

Thies-Reis Syndrome

Deafness, Conductive, With Stapes Fixation

Deafness 3, Conductive, With Stapes Fixation

Deafness, Mixed, With Perilymphatic Gusher

Conductive Deafness 3 With Stapes Fixation

Conductive Deafness With Stapes Fixation

Mixed Deafness With Perilymphatic Gusher

X-Linked Deafness Type 2

X-Linked Mixed Conductive And Neurosensory Hearing Loss

X-Linked Mixed Conductive And Sensorineural Hearing Loss

X-Linked Sensorineural Deafness

X-Linked Stapes Gusher Syndrome

Deafness Mixed With Perilymphatic Gusher, X-Linked

Dfn 3 Nonsyndromic Hearing Loss And Deafness

Gusher Syndrome

Thies Reis Syndrome

Progressive Hearing Loss With Stapes Fixation

Deafness, X-Linked, 2

Deafness Mixed With Perilymph Gusher X-Linked

Deafness, X-Linked, Type 2

Progressive Hearing Loss Stapes Fixation
Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Epididymis Adenocarcinoma

Adenocarcinoma Of The Epididymis
Epididymis Cancer

Malignant Tumor Of Epididymis

Malignant Epididymal Tumor

Malignant Neoplasm Of Epididymis

Neoplasm Of Epididymis
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B1360 Chlorquinaldol 99.47% Unkown
Pre-clinical Phase
Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-101486 LF3 Antagonist 99.55% Unkown
HY-100760 Toxoflavin Inhibitor 99.92% Unkown
HY-P10392B aStAx-35R TFA 99.18% Unkown
HY-100760S Toxoflavin-13C4 Inhibitor / Unkown
HY-124826 BC21 Inhibitor / Unkown
HY-149858 β-catenin-IN-7 Inhibitor / Unkown
HY-157126 Pterostilbene-isothiocyanate Inhibitor / Unkown
HY-P10392 aStAx-35R / Unkown
HY-RS14307 TCF4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-119966 CCT036477 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TCF4 VGNC VGNC:47197
Bos taurus TCF4 VGNC VGNC:35694
Macaca mulatta TCF4 VGNC VGNC:78288
Rattus norvegicus TCF4 RGD RGD:69271
Felis catus TCF4 VGNC VGNC:66027
Mus musculus TCF4 MGD MGI:98506
Others TCF4 NCBI