2. Gene
  3. GNGT1 - G protein subunit gamma transducin 1 Gene

GNGT1 - G protein subunit gamma transducin 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GNG1; HG3G1

Gene ID: 2792 | Gene type: protein coding

About GNGT1

Cytogenetic location: 7q21.3 Genomic coordinates (GRCh38): 7:93,906,567-93,911,265 (from NCBI)

This gene has 5 transcripts (splice variants), 143 orthologues and 11 paralogues. Restricted expression toward placenta (RPKM 1.6).

Summary

This gene encodes the gamma subunit of transducin, a guanine nucleotide-binding protein (G protein) that is found in rod outer segments. Transducin, also known as GMPase, mediates the activation of a cyclic GTP-specific (guanosine monophosphate) phosphodiesterase by rhodopsin. [provided by RefSeq, Jul 2016]

GNGT1 Products(2)

mRNA Protein Name
NM_001329426.2 NP_001316355.1 guanine nucleotide-binding protein G(T) subunit gamma-T1 precursor
NM_021955.5 NP_068774.1 guanine nucleotide-binding protein G(T) subunit gamma-T1 precursor
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GNGT1 Protein Structure

G-gamma

G-gamma: GGL domain (10 - 73)

  • 0
  • 74 a.a.
Protein Preferred Names Protein Names

guanine nucleotide-binding protein G(T) subunit gamma-T1

guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1

GNGT1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
GNGT1 P63211 ZNF277 Homo sapiens Q8WWA6
Y2H Prey Pooling
25416956
Intra
GNGT1 P63211 ZNF277 Homo sapiens G5E9M4
Y2H Prey Pooling
32296183
Intra
GNGT1 P63211 ZNF277 Homo sapiens G5E9M4
Y2H Array
32296183
Intra
GNGT1 P63211 PDCL Homo sapiens Q13371
Anti Tag CoIP
33961781
Intra
GNGT1 P63211 UBXN4 Homo sapiens Q92575
Y2H Prey Pooling
32296183
Intra
GNGT1 P63211 UBXN4 Homo sapiens Q92575
Validated Y2H
32296183
Intra
GNGT1 P63211 UBXN4 Homo sapiens Q92575
Y2H Array
32296183
Intra
GNGT1 P63211 GORASP2 Homo sapiens Q9H8Y8
Validated Y2H
32296183
Intra
GNGT1 P63211 GORASP2 Homo sapiens Q9H8Y8
Y2H Prey Pooling
32296183
Intra
GNGT1 P63211 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
32296183
Intra
GNGT1 P63211 MSANTD4 Homo sapiens Q8NCY6
Validated Y2H
32296183
Intra
GNGT1 P63211 MSANTD4 Homo sapiens Q8NCY6
Y2H Array
32296183
Intra
GNGT1 P63211 MSANTD4 Homo sapiens Q8NCY6
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GNGT1 Proteins

Cat. No. Product Name Accession Purity
HY-P76369 GNGT1 Protein, Human (His) P63211 (P2-C71) ≥95%

Related Diseases

Diseases Alias
Night Blindness, Congenital Stationary, Autosomal Dominant 2

Congenital Stationary Night Blindness Autosomal Dominant 2

CSNBAD2

Hemeralopia

Night Blindness, Congenital Stationary, Rambusch Type

Rambusch Type Congenital Stationary Night Blindness

Congenital Stationary Night Blindness Rambusch Type

Hemeralopia Congenital Essential

Blindness, Night, Stationary, Congenital, Autosomal Dominant, Type 2
Leber Plus Disease

Leber Congenital Amaurosis

Lca

Leber'S Amaurosis

Leber'S Disease

Amaurosis Congenita Of Leber

Amaurosis Congenita Of Leber, Type 1

Lhon Plus Disease

Congenital Absence Of The Rods And Cones

Congenital Retinal Blindness

Crb

Congenital Amaurosis Of Retinal Origin

Leber'S Congenital Amaurosis

Leber Congenital Amaurosis 1

Leber'S Congenital Tapetoretinal Degeneration

Leber'S Congenital Tapetoretinal Dysplasia

Lca1

Leber Congenital Amaurosis Type 1

Retinal Blindness, Congenital

Amaurosis, Leber Congenital

Dysgenesis Neuroepithelialis Retinae

Hereditary Epithelial Dysplasia Of Retina

Hereditary Retinal Aplasia

Heredoretinopathia Congenitalis

Leber Abiotrophy

Leber Congenital Tapetoretinal Degeneration

Lebers Congenital Amaurosis

Optic Atrophy, Hereditary, Leber
Fundus Dystrophy

Retinal Dystrophy

Retinal Dystrophies

Dystrophy, Retinal
Cone-Rod Dystrophy 2

Cone-Rod Dystrophy

CORD2

Cone-Rod Retinal Dystrophy

Rcrd2

Cone-Rod Retinal Dystrophy 2

Crd2

Cord

Crd

Retinal Cone-Rod Dystrophy

Cone-Rod Retinal Dystrophy-2

Retinal Cone-Rod Dystrophy 2

Tapetoretinal Degeneration

Cone-Rod Degeneration

Cone Rod Dystrophy

Dystrophy, Cone-Rod

Dystrophy, Cone-Rod, Type 2

Retinitis Pigmentosa

Retinitis Pigmentosa 2

Progressive Cone-Rod Dystrophy
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05562 GNGT1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta GNGT1 VGNC VGNC:73098
Mus musculus GNGT1 MGD MGI:109165
Felis catus GNGT1 VGNC VGNC:62624
Bos taurus GNGT1 VGNC VGNC:29470
Rattus norvegicus GNGT1 RGD RGD:1595475
Canis familiaris GNGT1 VGNC VGNC:41324
Others GNGT1 NCBI