2. Gene
  3. GP2 - glycoprotein 2 Gene

GP2 - glycoprotein 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ZAP75

Gene ID: 2813 | Gene type: protein coding

About GP2

Cytogenetic location: 16p12.3 Genomic coordinates (GRCh38): 16:20,309,574-20,327,513 (from NCBI)

This gene has 11 transcripts (splice variants), 374 orthologues and 5 paralogues. Restricted expression toward pancreas (RPKM 2558.6).

Summary

This gene encodes an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. The encoded protein binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GP2 Products(4)

mRNA Protein Name
NM_001007240.3 NP_001007241.2 pancreatic secretory granule membrane major glycoprotein GP2 isoform 1 preproprotein
NM_001007241.3 NP_001007242.2 pancreatic secretory granule membrane major glycoprotein GP2 isoform 3 precursor
NM_001007242.3 NP_001007243.2 pancreatic secretory granule membrane major glycoprotein GP2 isoform 4 precursor
NM_001502.4 NP_001493.2 pancreatic secretory granule membrane major glycoprotein GP2 isoform 2 precursor
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables antigen binding IDA
IDA: Inferred from direct assay
19907495 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence Reference Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
19907495 GOA
located in endosome IDA
IDA: Inferred from direct assay
19907495 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GP2 Protein Structure

Zona_pellucida

Zona_pellucida: Zona pellucida-like domain (229 - 479)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 537 a.a.
Protein Preferred Names Protein Names

pancreatic secretory granule membrane major glycoprotein GP2

glycoprotein 2 (zymogen granule membrane)

Related Diseases

Diseases Alias
Argentine Hemorrhagic Fever

Argentinian Hemorrhagic Fever

Junin Hemorrhagic Fever

Hemorrhagic Fever, Argentinian

Ahf - [Argentinian Haemorrhagic Fever]

Argentine Haemorrhagic Fever

Junin Haemorrhagic Fever
Bolivian Hemorrhagic Fever

Machupo Hemorrhagic Fever

Hemorrhagic Fever, Bolivian

Bhf - [Bolivian Haemorrhagic Fever]

Machupo Haemorrhagic Fever
Venezuelan Hemorrhagic Fever

Guanarito Hemorrhagic Fever

Vehf - [Venezuelan Haemorrhagic Fever]
Marburg Hemorrhagic Fever

Marburg Virus Disease

Marburg Disease

Green Monkey Disease

Mhf

Vervet Monkey Disease

Mard - [Marburg Disease]

Mvd - [Marburg Virus Disease]

Marburg Haemorrhagic Fever

Mhf - [Marburg Haemorrhagic Fever]
Inflammatory Bowel Disease 29

IBD29

{Inflammatory Bowel Disease 29}
Brazilian Hemorrhagic Fever

Sabia Hemorrhagic Fever
Ebola Hemorrhagic Fever

Ebola Virus Disease

Viral Hemorrhagic Fever

Hemorrhagic Fever, Ebola

Ebola

Ehf

Ebola Fever

Hemorrhagic Fevers, Viral

Ebola Haemorrhagic Fever

Ebod - [Ebola Disease]

Evd - [Ebola Virus Disease]

Ebola Virus Haemorrhagic Fever

Vhf - [Viral Haemorrhagic Fever] Nos

Viral Haemorrhagic Fever, Not Otherwise Specified
Lassa Fever

Lf

Lassa Hemorrhagic Fever

Lf - [Lassa Fever]
Lujo Hemorrhagic Fever

Zambian Hemorrhagic Fever
Foodborne Botulism

Botulism

Botulism Poisoning

Intoxication With Clostridium Botulinum Toxin

Wound Botulism

Food Poisoning Due To Clostridium Botulinum

Infection Due To Clostridium Botulinum

Infant Botulism

Intoxication Botulism

Botulism, Infantile

Clostridium Botulinum Poisoning

Botulism Nos
Acute Pancreatitis

Pancreatitis

Pancreatitis, Acute Necrotizing

Pancreatitis Nos

Acute Pancreas Inflammation
Blessig'S Cysts

Microcystoid Retinal Degeneration

Blessig Cysts

Iwanoff'S Cysts

Microcystoid Degeneration Of Retina
De Quervain Disease

Radial Styloid Tenosynovitis

Tenosynovitis, De Quervain'S

De Quervain'S Disease

Tenosynovitis Of Radial Styloid Process

Stenosans Tenosynovitis
Intestinal Tuberculosis

Tuberculosis Of Intestine

Tuberculosis Of Intestines
Bagassosis

Sugar Cane Worker Pneumonitis

Bagasse Workers' Lung

Bagasse Disease

Bagasse Disease Or Pneumonitis

Bagasse Workers' Disease

Fibrosis Of Lung With Bagassosis

Sugar Cane Workers' Hypersensitivity Pneumonitis

Bagasse Pneumonitis

Hypersensitivity Pneumonitis With Bagassosis
Gastrointestinal Tuberculosis

Tuberculosis Of Intestines, Peritoneum And Mesenteric Glands

Tuberculosis, Gastrointestinal

Tuberculosis Of Gastrointestinal Tract

Tuberculosis Of Intestines, Peritoneum, And Mesenteric Glands
Stuttering

Stammering

Familial Persistent Stuttering

Stuttering, Familial Persistent 1
Hemochromatosis, Type 1

Hemochromatosis

Hemochromatosis Type 1

Hereditary Hemochromatosis

Hh

HFE1

Hfe Hemochromatosis, Modifier Of

Symptomatic Form Of Classic Hemochromatosis

Symptomatic Form Of Hemochromatosis Type 1

Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis

Haemochromatosis

Iron Storage Disorder

Bronze Diabetes

Hereditary Haemochromatosis

Hlah

Hfe

Hemochromatosis, Hereditary

Diabetes Bronze

Classic Hemochromatosis

Hfe-Associated Hereditary Hemochromatosis

Hemochromatosis Classic

Bronzed Cirrhosis

Familial Hemochromatosis

Genetic Hemochromatosis

Hc

Pigmentary Cirrhosis

Primary Hemochromatosis

Troisier-Hanot-Chauffard Syndrome

Von Recklenhausen-Applebaum Disease

Hemochromatosis 1

Primary Hereditary Hemochromatosis

Bronze Cirrhosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-17367A Atazanavir sulfate 99.94% Yes
HY-17367 Atazanavir 99.86% Yes
Pre-clinical Phase
Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-147089 PRRSV/CD163-IN-1 Inhibitor 98.55% Unkown
HY-P1855 HER2/neu (654-662) GP2 98.04% Unkown
HY-107471 CB2 receptor agonist 3 Agonist 99.86% Unkown
HY-159857 Gp(2′-5′)Ap sodium / Unkown
HY-17367S2 Atazanavir-d9 / Unkown
HY-17367S3 Atazanavir-d5 / Unkown
HY-17367S4 Atazanavir-d6 99.28% Unkown
HY-P5695 GP-2B Inhibitor / Unkown
HY-RS05609 GP2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-U00191 GP2-114 / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus GP2 RGD RGD:621695
Macaca mulatta GP2 VGNC VGNC:73114
Mus musculus GP2 MGD MGI:1914383
Bos taurus GP2 VGNC VGNC:29505
Canis familiaris GP2 VGNC VGNC:41356
Felis catus GP2 VGNC VGNC:80577
Macaca fascicularis GP2 NCBI NCBI:102117957
Others GP2 NCBI