CB2 receptor agonist 3  (Synonyms: GP2a)

CB2 receptor agonist 3 is a robust and selective CB2 cannabinoid agonist with K_is of 7.6 and 900 nM for CB2 and CB1, respectively. CB2 receptor agonist 3 significantly increases P-ERK 1/2 expression in HL-60 cells^[1].

CB2 receptor agonist 3 (Compound 2a) is also shown to be agonist in an in vitro model based on human promyelocytic leukemia HL-60 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

440.36

C₂₄H₂₃Cl₂N₃O

919077-81-9

Solid

White to off-white

O=C(C1=NN(C2=C1CC3=C2C=CC(C)=C3)C4=CC=C(C=C4Cl)Cl)NC5CCCCC5

Room temperature in continental US; may vary elsewhere.

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Murineddu G, et al. Tricyclic pyrazoles. 4. Synthesis and biological evaluation of analogues of the robust and selective CB2 cannabinoid ligand 1-(2',4'-dichlorophenyl)-6-methyl-N-piperidin-1-yl-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamide. J Med Chem.  [Content Brief]