PPP2R3B - protein phosphatase 2 regulatory subunit B''beta Gene

Homo sapiens

Also known as PR48; PR70; NYREN8; PPP2R3L; PPP2R3LY

Gene ID: 28227 | Gene type: protein coding

About PPP2R3B

Cytogenetic location: Xp22.33 Genomic coordinates (GRCh38): X:333,933-386,907 (from NCBI)

This gene has 10 transcripts (splice variants), 1 gene allele, 77 orthologues and 1 paralogue. Broad expression in heart (RPKM 9.0), testis (RPKM 5.0) and 23 other tissues.

Summary

Protein Phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein Phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the beta subfamily of regulatory subunit B''. [provided by RefSeq, Apr 2010]

PPP2R3B Products(1)

mRNA	Protein	Name
NM_013239.5	NP_037371.2	serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9847399	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP2R3B Protein Structure

EF-hand_7

0
100
200
300
400
500
575 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta

NY-REN-8 antigen

PPP2R3B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PPP2R3B	Q9Y5P8	DUSP12	Homo sapiens	Q9UNI6	Y2H Array	25416956
Intra	PPP2R3B	Q9Y5P8	DUSP12	Homo sapiens	Q9UNI6	Y2H	21516116

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Pylorus Cancer

Ca Pylorus - Stomach	Malignant Neoplasm Of Prepylorus
Malignant Neoplasm Of Pylorus Of Stomach	Malignant Tumor Of Pylorus
Malignant Neoplasm Of Pylorus

Leri-Weill Dyschondrosteosis

LWD	Dyschondrosteosis
Dco	Léri-Weill Dyschondrosteosis
Leri Weill Dyschondrosteosis	Leri-Weill Syndrome
Leri-Weil Syndrome	Dyschondrosteosis, Leri-Weill

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11016	PPP2R3B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PPP2R3B	RGD	RGD:1588134
Felis catus	PPP2R3B	VGNC	VGNC:108523
Mus musculus	PPP2R3B	MGD	MGI:1335093

Name
Email *

	Sorry, but the email address you supplied was invalid.