1. Gene
  2. PPP2R3B - protein phosphatase 2 regulatory subunit B''beta Gene

PPP2R3B - protein phosphatase 2 regulatory subunit B''beta Gene

Homo sapiens

Also known as PR48; PR70; NYREN8; PPP2R3L; PPP2R3LY

Gene ID: 28227 | Gene type: protein coding

About PPP2R3B

Cytogenetic location: Xp22.33 Genomic coordinates (GRCh38): X:333,933-386,907 (from NCBI)

This gene has 10 transcripts (splice variants), 1 gene allele, 77 orthologues and 1 paralogue. Broad expression in heart (RPKM 9.0), testis (RPKM 5.0) and 23 other tissues.

Summary

Protein Phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein Phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the beta subfamily of regulatory subunit B''. [provided by RefSeq, Apr 2010]

PPP2R3B Products(1)

mRNA Protein Name
NM_013239.5 NP_037371.2 serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta

PPP2R3B Protein Structure

EF-hand_7

EF-hand_7: EF-hand domain pair (323 - 417)

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  • 575 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta

NY-REN-8 antigen

Related Diseases

Diseases Alias
Pylorus Cancer

Ca Pylorus - Stomach

Malignant Neoplasm Of Prepylorus

Malignant Neoplasm Of Pylorus Of Stomach

Malignant Tumor Of Pylorus

Malignant Neoplasm Of Pylorus

Leri-Weill Dyschondrosteosis

LWD

Dyschondrosteosis

Dco

Léri-Weill Dyschondrosteosis

Leri Weill Dyschondrosteosis

Leri-Weill Syndrome

Leri-Weil Syndrome

Dyschondrosteosis, Leri-Weill

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PPP2R3B RGD RGD:1588134
Felis catus PPP2R3B VGNC VGNC:108523
Mus musculus PPP2R3B MGD MGI:1335093