GPM6A - glycoprotein M6A Gene

Homo sapiens

Also known as M6A; GPM6

Gene ID: 2823 | Gene type: protein coding

About GPM6A

Cytogenetic location: 4q34.2 Genomic coordinates (GRCh38): 4:175,632,937-176,002,691 (from NCBI)

This gene has 21 transcripts (splice variants), 289 orthologues and 2 paralogues. Biased expression in brain (RPKM 247.1) and lung (RPKM 8.5).

Summary

Predicted to enable Calcium Channel activity. Involved in neuron migration and stem cell differentiation. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

GPM6A Products(7)

mRNA	Protein	Name
NM_001261447.1	NP_001248376.1	neuronal membrane glycoprotein M6-a isoform 2
NM_001261448.1	NP_001248377.1	neuronal membrane glycoprotein M6-a isoform 4
NM_001388090.1	NP_001375019.1	neuronal membrane glycoprotein M6-a isoform 5
NM_001388091.1	NP_001375020.1	neuronal membrane glycoprotein M6-a isoform 5
NM_005277.5	NP_005268.1	neuronal membrane glycoprotein M6-a isoform 1
NM_201591.3	NP_963885.1	neuronal membrane glycoprotein M6-a isoform 1
NM_201592.3	NP_963886.1	neuronal membrane glycoprotein M6-a isoform 3

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17500595	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in neuron migration	IDA IDA: Inferred from direct assay	19298174	GOA
involved in stem cell differentiation	IDA IDA: Inferred from direct assay	19298174	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPM6A Protein Structure

Myelin_PLP

0
100
200
278 a.a.

Protein Preferred Names

Protein Names

neuronal membrane glycoprotein M6-a

GPM6A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GPM6A	P51674	TGFBR2	Homo sapiens	P37173	Y2H Pooling	32814053
Intra	GPM6A	P51674	TGFBR2	Homo sapiens	P37173	Validated Y2H	32814053
Intra	GPM6A	P51674	TGFBR2	Homo sapiens	P37173	Y2H Array	32814053
Intra	GPM6A	P51674	ZDHHC17	Homo sapiens	Q8IUH5	Lumier	24705354
Intra	GPM6A	P51674	ZDHHC17	Homo sapiens	Q8IUH5	Y2H Array	24705354
Intra	GPM6A	P51674	ZDHHC17	Homo sapiens	Q8IUH5	IF	24705354
Intra	GPM6A	P51674	ICAM5	Homo sapiens	Q9UMF0	Validated Y2H	32814053
Intra	GPM6A	P51674	ICAM5	Homo sapiens	Q9UMF0	Y2H Array	32814053
Intra	GPM6A	P51674	ICAM5	Homo sapiens	Q9UMF0	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Retinitis Pigmentosa 29

RP29

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05643	GPM6A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GPM6A	MGD	MGI:107671
Macaca mulatta	GPM6A	VGNC	VGNC:73121
Felis catus	GPM6A	VGNC	VGNC:67411
Bos taurus	GPM6A	VGNC	VGNC:97275
Rattus norvegicus	GPM6A	RGD	RGD:631368
Canis familiaris	GPM6A	VGNC	VGNC:41385

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