2. Gene
  3. ZDHHC17 - zinc finger DHHC-type palmitoyltransferase 17 Gene

ZDHHC17 - zinc finger DHHC-type palmitoyltransferase 17 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HIP3; HYPH; HIP14; DHHC17; DHHC-17; HSPC294

Gene ID: 23390 | Gene type: protein coding

About ZDHHC17

Cytogenetic location: 12q21.2 Genomic coordinates (GRCh38): 12:76,764,115-76,853,701 (from NCBI)

This gene has 16 transcripts (splice variants), 212 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 20.0), endometrium (RPKM 12.2) and 25 other tissues.

Summary

Enables identical protein binding activity and protein-cysteine S-palmitoyltransferase activity. Involved in lipoprotein transport and protein palmitoylation. Located in Golgi membrane; Golgi-associated vesicle membrane; and aggresome. [provided by Alliance of Genome Resources, Apr 2022]

ZDHHC17 Products(2)

mRNA Protein Name
NM_001359626.1 NP_001346555.1 palmitoyltransferase ZDHHC17 isoform 2
NM_015336.4 NP_056151.2 palmitoyltransferase ZDHHC17 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
24705354 GOA
enables palmitoyltransferase activity IDA
IDA: Inferred from direct assay
23034182 GOA
enables palmitoyltransferase activity IMP
IMP: Inferred from mutant phenotype
24705354 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15603740 GOA
enables protein-cysteine S-palmitoyltransferase activity IDA
IDA: Inferred from direct assay
15603740 GOA
Biological Process GO Annotation Evidence Reference Source
involved in lipoprotein transport IDA
IDA: Inferred from direct assay
15603740 GOA
involved in protein palmitoylation IDA
IDA: Inferred from direct assay
23034182 GOA
involved in protein palmitoylation IMP
IMP: Inferred from mutant phenotype
24705354 GOA
involved in regulation of programmed cell death IDA
IDA: Inferred from direct assay
27911442 GOA
Cellular Component GO Annotation Evidence Reference Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
16647879 GOA
located in Golgi membrane IDA
IDA: Inferred from direct assay
18794299 GOA
located in Golgi-associated vesicle membrane IDA
IDA: Inferred from direct assay
18794299 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZDHHC17 Protein Structure

Ank_2

Ank_2: Ankyrin repeats (3 copies) (63 - 118)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (128 - 202)

Ank

Ank: Ankyrin repeat (226 - 255)

DHHC

DHHC: DHHC palmitoyltransferase (402 - 568)

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  • 400
  • 500
  • 632 a.a.
Protein Preferred Names Protein Names

palmitoyltransferase ZDHHC17

DHHC domain-containing cysteine-rich protein 17

ZDHHC17 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra ZDHHC17 Q8IUH5 CAPN2 Homo sapiens P17655
Lumier
24705354
Intra ZDHHC17 Q8IUH5 DNM2 Homo sapiens P50570-2
Validated Y2H
32814053
Intra ZDHHC17 Q8IUH5 DNM2 Homo sapiens P50570-2
Y2H Array
32814053
Intra ZDHHC17 Q8IUH5 DNM2 Homo sapiens P50570-2
Y2H Pooling
32814053
Intra ZDHHC17 Q8IUH5 GDAP1 Homo sapiens Q8TB36
Validated Y2H
32814053
Intra ZDHHC17 Q8IUH5 GDAP1 Homo sapiens Q8TB36
Y2H Pooling
32814053
Intra ZDHHC17 Q8IUH5 GDAP1 Homo sapiens Q8TB36
Y2H Array
32814053
Intra ZDHHC17 Q8IUH5 SPRY3 Homo sapiens O43610
Y2H Prey Pooling
32296183
Intra ZDHHC17 Q8IUH5 SPRY3 Homo sapiens O43610
Y2H Array
32296183
Intra ZDHHC17 Q8IUH5 ZHX1-C8orf76 Homo sapiens Q96EF9
Validated Y2H
32814053
Intra ZDHHC17 Q8IUH5 ZHX1-C8orf76 Homo sapiens Q96EF9
Y2H Array
32814053
Intra ZDHHC17 Q8IUH5 ZHX1-C8orf76 Homo sapiens Q96EF9
Y2H Pooling
32814053
Intra ZDHHC17 Q8IUH5 RFFL Homo sapiens Q8WZ73-3
Y2H Pooling
32814053
Intra ZDHHC17 Q8IUH5 RFFL Homo sapiens Q8WZ73-3
Validated Y2H
32814053
Intra ZDHHC17 Q8IUH5 RFFL Homo sapiens Q8WZ73-3
Y2H Array
32814053
Intra ZDHHC17 Q8IUH5 EIF3E Homo sapiens P60228
Y2H Array
24705354
Intra ZDHHC17 Q8IUH5 FEZ2 Homo sapiens Q9UHY8
Lumier
24705354
Intra ZDHHC17 Q8IUH5 SPRED1 Homo sapiens Q7Z699
Y2H Array
24705354
Intra ZDHHC17 Q8IUH5 SPRED1 Homo sapiens Q7Z699
Lumier
24705354
Intra ZDHHC17 Q8IUH5 SNAP25 Homo sapiens P60880
Enzymatic Study
15603740
Intra ZDHHC17 Q8IUH5 GOLGA2 Homo sapiens Q08379
Y2H Array
24705354
Intra ZDHHC17 Q8IUH5 EVL Homo sapiens Q9UI08-2
Y2H Array
24705354
Intra ZDHHC17 Q8IUH5 EVL Homo sapiens Q9UI08-2
Lumier
24705354
Intra ZDHHC17 Q8IUH5 SPRED2 Homo sapiens Q7Z698
Y2H Array
24705354
Intra ZDHHC17 Q8IUH5 GPM6A Homo sapiens P51674
Lumier
24705354
Intra ZDHHC17 Q8IUH5 GPM6A Homo sapiens P51674
Anti Tag CoIP
24705354
Intra ZDHHC17 Q8IUH5 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra ZDHHC17 Q8IUH5 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra ZDHHC17 Q8IUH5 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra ZDHHC17 Q8IUH5 SPRY2 Homo sapiens O43597
Y2H Prey Pooling
25416956
Intra ZDHHC17 Q8IUH5 SNAP23 Homo sapiens O00161
Lumier
24705354
Intra ZDHHC17 Q8IUH5 SNAP23 Homo sapiens O00161
Y2H Array
24705354
Intra ZDHHC17 Q8IUH5 PDPK1 Homo sapiens O15530-4
Lumier
24705354
Intra ZDHHC17 Q8IUH5 PDPK1 Homo sapiens O15530-4
Y2H Array
24705354
Intra ZDHHC17 Q8IUH5 CSNK1D Homo sapiens P48730-2
Y2H Array
24705354
Intra ZDHHC17 Q8IUH5 CSNK1D Homo sapiens P48730-2
Lumier
24705354
Intra ZDHHC17 Q8IUH5 LASP1 Homo sapiens Q14847-2
Lumier
24705354
Intra ZDHHC17 Q8IUH5 LASP1 Homo sapiens Q14847-2
Y2H Array
24705354
Intra ZDHHC17 Q8IUH5 q7z783_human Homo sapiens Q7Z783
Lumier
24705354
Intra ZDHHC17 Q8IUH5 q7z783_human Homo sapiens Q7Z783
Y2H Array
24705354
Intra ZDHHC17 Q8IUH5 RAB39B Homo sapiens Q96DA2
Lumier
24705354
Intra ZDHHC17 Q8IUH5 RAB39B Homo sapiens Q96DA2
Y2H Array
24705354
Intra ZDHHC17 Q8IUH5 PLEKHB1 Homo sapiens Q9UF11-4
Lumier
24705354
Intra ZDHHC17 Q8IUH5 PIK3R1 Homo sapiens P27986-2
Lumier
24705354
Intra ZDHHC17 Q8IUH5 PDE4D Homo sapiens Q08499-8
Lumier
24705354
Intra ZDHHC17 Q8IUH5 IFT20 Homo sapiens Q8IY31-3
Lumier
24705354
Intra ZDHHC17 Q8IUH5 OPTN Homo sapiens Q96CV9-2
Y2H Array
24705354
Intra ZDHHC17 Q8IUH5 CDCA7L Homo sapiens Q96GN5-2
Lumier
24705354
Intra ZDHHC17 Q8IUH5 BAIAP2 Homo sapiens Q9UQB8-3
Lumier
24705354
Intra ZDHHC17 Q8IUH5 BAIAP2 Homo sapiens Q9UQB8-6
Lumier
24705354
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Huntington Disease

Huntington'S Disease

Huntington Chorea

Huntington'S Chorea

HD

Huntington Chronic Progressive Hereditary Chorea

Juvenile Huntington Disease

Chronic Progressive Chorea

Chronic Progressive Hereditary Chorea

Hc - [Huntington Chorea]

Hereditary Chorea

Progressive Hereditary Chorea
Type 1 Diabetes Mellitus 2

Diabetes Mellitus, Noninsulin-Dependent, 1

Diabetes Mellitus, Insulin-Dependent, 2

IDDM2

Insulin-Dependent Diabetes Mellitus 2

NIDDM1

Diabetes Mellitus, Noninsulin-Dependent 1

T1D2

Type 2 Diabetes Mellitus 1

T2D1

Noninsulin-Dependent Diabetes Mellitus 1

Diabetes Mellitus, Non-Insulin-Dependent, 1

Type 2 Diabetes Mellitus 1, Susceptibility To

Diabetes Mellitus, Insulin-Dependent, Type 2

Diabetes Mellitus, Non-Insulin-Dependent
Neuronal Ceroid Lipofuscinosis

Hereditary Ceroid Lipofuscinosis

Batten Disease

Ncl

Neuronal Ceroid-Lipofuscinoses

Lipofuscinosis, Ceroid, Neuronal

Juvenile Neuronal Ceroid Lipofuscinosis

Cerebromacular Dystrophy

Cerebromacular Degeneration

Ceroid-Lipofuscinosis

Ncl - [Neuronal Ceroid Lipofuscinosis]

Amaurotic Familial Idiocy

Amaurotic Idiocy

Amaurotic Idiot

Neuronal Lipofuscinosis

Pigmentary Retinal Lipoid Neuronal Heredodegeneration
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS16016 ZDHHC17 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ZDHHC17 RGD RGD:1595790
Felis catus ZDHHC17 VGNC VGNC:67206
Macaca mulatta ZDHHC17 VGNC VGNC:79137
Bos taurus ZDHHC17 VGNC VGNC:37132
Mus musculus ZDHHC17 MGD MGI:2445110
Canis familiaris ZDHHC17 VGNC VGNC:48583