ZDHHC17 - zinc finger DHHC-type palmitoyltransferase 17 Gene

Homo sapiens

Also known as HIP3; HYPH; HIP14; DHHC17; DHHC-17; HSPC294

Gene ID: 23390 | Gene type: protein coding

About ZDHHC17

Cytogenetic location: 12q21.2 Genomic coordinates (GRCh38): 12:76,764,115-76,853,701 (from NCBI)

This gene has 16 transcripts (splice variants), 212 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 20.0), endometrium (RPKM 12.2) and 25 other tissues.

Summary

Enables identical protein binding activity and protein-cysteine S-palmitoyltransferase activity. Involved in lipoprotein transport and protein palmitoylation. Located in Golgi membrane; Golgi-associated vesicle membrane; and aggresome. [provided by Alliance of Genome Resources, Apr 2022]

ZDHHC17 Products(2)

mRNA	Protein	Name
NM_001359626.1	NP_001346555.1	palmitoyltransferase ZDHHC17 isoform 2
NM_015336.4	NP_056151.2	palmitoyltransferase ZDHHC17 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	24705354	GOA
enables palmitoyltransferase activity	IDA IDA: Inferred from direct assay	23034182	GOA
enables palmitoyltransferase activity	IMP IMP: Inferred from mutant phenotype	24705354	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15603740	GOA
enables protein-cysteine S-palmitoyltransferase activity	IDA IDA: Inferred from direct assay	15603740	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in lipoprotein transport	IDA IDA: Inferred from direct assay	15603740	GOA
involved in protein palmitoylation	IDA IDA: Inferred from direct assay	23034182	GOA
involved in protein palmitoylation	IMP IMP: Inferred from mutant phenotype	24705354	GOA
involved in regulation of programmed cell death	IDA IDA: Inferred from direct assay	27911442	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	16647879	GOA
located in Golgi membrane	IDA IDA: Inferred from direct assay	18794299	GOA
located in Golgi-associated vesicle membrane	IDA IDA: Inferred from direct assay	18794299	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZDHHC17 Protein Structure

Ank_2

Ank

DHHC

0
100
200
300
400
500
632 a.a.

Protein Preferred Names

Protein Names

palmitoyltransferase ZDHHC17

DHHC domain-containing cysteine-rich protein 17

ZDHHC17 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZDHHC17	Q8IUH5	CAPN2	Homo sapiens	P17655	Lumier	24705354
Intra	ZDHHC17	Q8IUH5	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
Intra	ZDHHC17	Q8IUH5	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053
Intra	ZDHHC17	Q8IUH5	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053
Intra	ZDHHC17	Q8IUH5	GDAP1	Homo sapiens	Q8TB36	Validated Y2H	32814053
Intra	ZDHHC17	Q8IUH5	GDAP1	Homo sapiens	Q8TB36	Y2H Pooling	32814053
Intra	ZDHHC17	Q8IUH5	GDAP1	Homo sapiens	Q8TB36	Y2H Array	32814053
Intra	ZDHHC17	Q8IUH5	SPRY3	Homo sapiens	O43610	Y2H Prey Pooling	32296183
Intra	ZDHHC17	Q8IUH5	SPRY3	Homo sapiens	O43610	Y2H Array	32296183
Intra	ZDHHC17	Q8IUH5	ZHX1-C8orf76	Homo sapiens	Q96EF9	Validated Y2H	32814053
Intra	ZDHHC17	Q8IUH5	ZHX1-C8orf76	Homo sapiens	Q96EF9	Y2H Array	32814053
Intra	ZDHHC17	Q8IUH5	ZHX1-C8orf76	Homo sapiens	Q96EF9	Y2H Pooling	32814053
Intra	ZDHHC17	Q8IUH5	RFFL	Homo sapiens	Q8WZ73-3	Y2H Pooling	32814053
Intra	ZDHHC17	Q8IUH5	RFFL	Homo sapiens	Q8WZ73-3	Validated Y2H	32814053
Intra	ZDHHC17	Q8IUH5	RFFL	Homo sapiens	Q8WZ73-3	Y2H Array	32814053
Intra	ZDHHC17	Q8IUH5	EIF3E	Homo sapiens	P60228	Y2H Array	24705354
Intra	ZDHHC17	Q8IUH5	FEZ2	Homo sapiens	Q9UHY8	Lumier	24705354
Intra	ZDHHC17	Q8IUH5	SPRED1	Homo sapiens	Q7Z699	Y2H Array	24705354
Intra	ZDHHC17	Q8IUH5	SPRED1	Homo sapiens	Q7Z699	Lumier	24705354
Intra	ZDHHC17	Q8IUH5	SNAP25	Homo sapiens	P60880	Enzymatic Study	15603740
Intra	ZDHHC17	Q8IUH5	GOLGA2	Homo sapiens	Q08379	Y2H Array	24705354
Intra	ZDHHC17	Q8IUH5	EVL	Homo sapiens	Q9UI08-2	Y2H Array	24705354
Intra	ZDHHC17	Q8IUH5	EVL	Homo sapiens	Q9UI08-2	Lumier	24705354
Intra	ZDHHC17	Q8IUH5	SPRED2	Homo sapiens	Q7Z698	Y2H Array	24705354
Intra	ZDHHC17	Q8IUH5	GPM6A	Homo sapiens	P51674	Lumier	24705354
Intra	ZDHHC17	Q8IUH5	GPM6A	Homo sapiens	P51674	Anti Tag CoIP	24705354
Intra	ZDHHC17	Q8IUH5	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	ZDHHC17	Q8IUH5	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	ZDHHC17	Q8IUH5	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	ZDHHC17	Q8IUH5	SPRY2	Homo sapiens	O43597	Y2H Prey Pooling	25416956
Intra	ZDHHC17	Q8IUH5	SNAP23	Homo sapiens	O00161	Lumier	24705354
Intra	ZDHHC17	Q8IUH5	SNAP23	Homo sapiens	O00161	Y2H Array	24705354
Intra	ZDHHC17	Q8IUH5	PDPK1	Homo sapiens	O15530-4	Lumier	24705354
Intra	ZDHHC17	Q8IUH5	PDPK1	Homo sapiens	O15530-4	Y2H Array	24705354
Intra	ZDHHC17	Q8IUH5	CSNK1D	Homo sapiens	P48730-2	Y2H Array	24705354
Intra	ZDHHC17	Q8IUH5	CSNK1D	Homo sapiens	P48730-2	Lumier	24705354
Intra	ZDHHC17	Q8IUH5	LASP1	Homo sapiens	Q14847-2	Lumier	24705354
Intra	ZDHHC17	Q8IUH5	LASP1	Homo sapiens	Q14847-2	Y2H Array	24705354
Intra	ZDHHC17	Q8IUH5	q7z783_human	Homo sapiens	Q7Z783	Lumier	24705354
Intra	ZDHHC17	Q8IUH5	q7z783_human	Homo sapiens	Q7Z783	Y2H Array	24705354
Intra	ZDHHC17	Q8IUH5	RAB39B	Homo sapiens	Q96DA2	Lumier	24705354
Intra	ZDHHC17	Q8IUH5	RAB39B	Homo sapiens	Q96DA2	Y2H Array	24705354
Intra	ZDHHC17	Q8IUH5	PLEKHB1	Homo sapiens	Q9UF11-4	Lumier	24705354
Intra	ZDHHC17	Q8IUH5	PIK3R1	Homo sapiens	P27986-2	Lumier	24705354
Intra	ZDHHC17	Q8IUH5	PDE4D	Homo sapiens	Q08499-8	Lumier	24705354
Intra	ZDHHC17	Q8IUH5	IFT20	Homo sapiens	Q8IY31-3	Lumier	24705354
Intra	ZDHHC17	Q8IUH5	OPTN	Homo sapiens	Q96CV9-2	Y2H Array	24705354
Intra	ZDHHC17	Q8IUH5	CDCA7L	Homo sapiens	Q96GN5-2	Lumier	24705354
Intra	ZDHHC17	Q8IUH5	BAIAP2	Homo sapiens	Q9UQB8-3	Lumier	24705354
Intra	ZDHHC17	Q8IUH5	BAIAP2	Homo sapiens	Q9UQB8-6	Lumier	24705354

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Huntington Disease

Huntington'S Disease	Huntington Chorea
Huntington'S Chorea	HD
Huntington Chronic Progressive Hereditary Chorea	Juvenile Huntington Disease
Chronic Progressive Chorea	Chronic Progressive Hereditary Chorea
Hc - [Huntington Chorea]	Hereditary Chorea
Progressive Hereditary Chorea

Type 1 Diabetes Mellitus 2

Diabetes Mellitus, Noninsulin-Dependent, 1	Diabetes Mellitus, Insulin-Dependent, 2
IDDM2	Insulin-Dependent Diabetes Mellitus 2
NIDDM1	Diabetes Mellitus, Noninsulin-Dependent 1
T1D2	Type 2 Diabetes Mellitus 1
T2D1	Noninsulin-Dependent Diabetes Mellitus 1
Diabetes Mellitus, Non-Insulin-Dependent, 1	Type 2 Diabetes Mellitus 1, Susceptibility To
Diabetes Mellitus, Insulin-Dependent, Type 2	Diabetes Mellitus, Non-Insulin-Dependent

Neuronal Ceroid Lipofuscinosis

Hereditary Ceroid Lipofuscinosis	Batten Disease
Ncl	Neuronal Ceroid-Lipofuscinoses
Lipofuscinosis, Ceroid, Neuronal	Juvenile Neuronal Ceroid Lipofuscinosis
Cerebromacular Dystrophy	Cerebromacular Degeneration
Ceroid-Lipofuscinosis	Ncl - [Neuronal Ceroid Lipofuscinosis]
Amaurotic Familial Idiocy	Amaurotic Idiocy
Amaurotic Idiot	Neuronal Lipofuscinosis
Pigmentary Retinal Lipoid Neuronal Heredodegeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16016	ZDHHC17 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ZDHHC17	RGD	RGD:1595790
Felis catus	ZDHHC17	VGNC	VGNC:67206
Macaca mulatta	ZDHHC17	VGNC	VGNC:79137
Bos taurus	ZDHHC17	VGNC	VGNC:37132
Mus musculus	ZDHHC17	MGD	MGI:2445110
Canis familiaris	ZDHHC17	VGNC	VGNC:48583

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