REC114 - REC114 meiotic recombination protein Gene

Homo sapiens

Also known as CT147; OOMD10; C15orf60

Gene ID: 283677 | Gene type: protein coding

About REC114

Cytogenetic location: 15q24.1 Genomic coordinates (GRCh38): 15:73,443,164-73,560,013 (from NCBI)

This gene has 2 transcripts (splice variants), 153 orthologues and is associated with 1 phenotype. Restricted expression toward testis (RPKM 17.1).

Summary

The protein encoded by this gene is orthologous to the mouse meiotic recombination protein REC114, which is involved in DNA double-strand break formation during meiosis. The encoded protein is conserved in most eukaryotes and was first discovered and characterized in yeast. [provided by RefSeq, Feb 2017]

REC114 Products(2)

mRNA	Protein	Name
NM_001042367.2	NP_001035826.1	meiotic recombination protein REC114 isoform 1
NM_001348772.2	NP_001335701.1	meiotic recombination protein REC114 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	31704776	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

REC114 Protein Structure

REC114-like

0
100
200
266 a.a.

Protein Preferred Names

Protein Names

meiotic recombination protein REC114

meiotic recombination protein REC114-like

REC114 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	REC114	Q7Z4M0	MEI4	Homo sapiens	A8MW99	Anti Tag CoIP	31704776

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Oocyte Maturation Defect 10

OOMD10

Infertility

Gestational Trophoblastic Neoplasm

Hydatidiform Mole	Molar Pregnancy
Gestational Trophoblastic Neoplasia	Gestational Trophoblastic Tumor
Gtn	Gestational Trophoblastic Disease
Gestational Trophoblastic Neoplasms	Hydatidiform Mole, Recurrent, 1
Hydatidiform Mole Benign	Trophoblastic Disease
Trophoblastic Disease Nos	Trophoblastic Disorder
Vesicular Mole Nos	Vesicular Mole
Hydatidiform Mole Nos

Trophoblastic Neoplasm

Trophoblastic Tumor

Trophoblastic Neoplasms

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11807	REC114 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	REC114	MGD	MGI:1920923
Felis catus	REC114	VGNC	VGNC:64559
Canis familiaris	REC114	VGNC	VGNC:54350
Bos taurus	REC114	VGNC	VGNC:106892
Rattus norvegicus	REC114	RGD	RGD:1311874
Macaca mulatta	REC114	VGNC	VGNC:76815

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