ZIK1 - zinc finger protein interacting with K protein 1 Gene

Homo sapiens

Also known as ZNF762

Gene ID: 284307 | Gene type: protein coding

About ZIK1

This gene has 8 transcripts (splice variants), 54 orthologues and 38 paralogues. Broad expression in thyroid (RPKM 2.1), testis (RPKM 1.9) and 24 other tissues.

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

ZIK1 Products(4)

mRNA	Protein	Name
NM_001010879.4	NP_001010879.2	zinc finger protein interacting with ribonucleoprotein K isoform 1
NM_001321145.2	NP_001308074.1	zinc finger protein interacting with ribonucleoprotein K isoform 2
NM_001321146.2	NP_001308075.1	zinc finger protein interacting with ribonucleoprotein K isoform 3
NM_001321147.2	NP_001308076.1	zinc finger protein interacting with ribonucleoprotein K isoform 4

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZIK1 Protein Structure

KRAB

zf-H2C2_2

0
100
200
300
400
487 a.a.

Protein Preferred Names

Protein Names

zinc finger protein interacting with ribonucleoprotein K

zinc finger protein 762

ZIK1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZIK1	Q3SY52	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	ZIK1	Q3SY52	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	ZIK1	Q3SY52	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Goldberg-Shprintzen Syndrome

Goldberg-Shprintzen Megacolon Syndrome	GOSHS
Megacolon-Microcephaly Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16078	ZIK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ZIK1	MGD	MGI:108070
Macaca mulatta	ZIK1	VGNC	VGNC:81611
Rattus norvegicus	ZIK1	RGD	RGD:1590949

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