RGMB - repulsive guidance molecule BMP co-receptor b Gene

Homo sapiens

Also known as DRAGON

Gene ID: 285704 | Gene type: protein coding

About RGMB

Cytogenetic location: 5q15 Genomic coordinates (GRCh38): 5:98,768,632-98,796,494 (from NCBI)

This gene has 7 transcripts (splice variants), 206 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 10.1), skin (RPKM 10.1) and 24 other tissues.

Summary

RGMB is a glycosylphosphatidylinositol (GPI)-anchored member of the repulsive guidance molecule family (see RGMA, MIM 607362) and contributes to the patterning of the developing nervous system (Samad et al., 2005 [PubMed 15671031]).[supplied by OMIM, Apr 2009]

RGMB Products(5)

mRNA	Protein	Name
NM_001012761.3	NP_001012779.2	repulsive guidance molecule B isoform 2
NM_001366508.1	NP_001353437.1	repulsive guidance molecule B isoform 1 precursor
NM_001366509.1	NP_001353438.1	repulsive guidance molecule B isoform 2
NM_001366510.1	NP_001353439.1	repulsive guidance molecule B isoform 2
NM_001366511.1	NP_001353440.1	repulsive guidance molecule B isoform 3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25938661	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RGMB Protein Structure

RGM_N

RGM_C

0
100
200
300
400
437 a.a.

Protein Preferred Names

Protein Names

repulsive guidance molecule B

DRG11-responsive axonal guidance and outgrowth of neurite

Recombinant RGMB Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76573	RGMB Protein, Human (HEK293, His)	Q6NW40/J3KNF6 (G46-N413)	≥95%

Related Diseases

Diseases

Alias

Hemochromatosis Type 2

Juvenile Hemochromatosis	Juvenile Hereditary Hemochromatosis
Hfe2	Jhh
Hemochromatosis Juvenile	Iron Overload Disease Juvenile
Hemochromatosis, Juvenile	Hemochromatosis, Type 2
Hemochromatosis	Hemochromatosis, Type 1

Hemochromatosis, Type 1

Hemochromatosis	Hemochromatosis Type 1
Hereditary Hemochromatosis	Hh
HFE1	Hfe Hemochromatosis, Modifier Of
Symptomatic Form Of Classic Hemochromatosis	Symptomatic Form Of Hemochromatosis Type 1
Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis	Haemochromatosis
Iron Storage Disorder	Bronze Diabetes
Hereditary Haemochromatosis	Hlah
Hfe	Hemochromatosis, Hereditary
Diabetes Bronze	Classic Hemochromatosis
Hfe-Associated Hereditary Hemochromatosis	Hemochromatosis Classic
Bronzed Cirrhosis	Familial Hemochromatosis
Genetic Hemochromatosis	Hc
Pigmentary Cirrhosis	Primary Hemochromatosis
Troisier-Hanot-Chauffard Syndrome	Von Recklenhausen-Applebaum Disease
Hemochromatosis 1	Primary Hereditary Hemochromatosis
Bronze Cirrhosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11895	RGMB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RGMB	RGD	RGD:1595392
Macaca mulatta	RGMB	VGNC	VGNC:76843
Felis catus	RGMB	VGNC	VGNC:102308
Mus musculus	RGMB	MGD	MGI:1916049
Bos taurus	RGMB	VGNC	VGNC:55306
Others	RGMB	NCBI

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