2. Gene
  3. GPR39 - G protein-coupled receptor 39 Gene

GPR39 - G protein-coupled receptor 39 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 2863 | Gene type: protein coding

About GPR39

Cytogenetic location: 2q21.2 Genomic coordinates (GRCh38): 2:132,416,805-132,646,582 (from NCBI)

This gene has 3 transcripts (splice variants), 219 orthologues and 15 paralogues. Broad expression in brain (RPKM 4.2), colon (RPKM 3.1) and 19 other tissues.

Summary

This gene is a member of the ghrelin receptor family and encodes a rhodopsin-type G-protein-coupled receptor (GPCR). The encoded protein is involved in zinc-dependent signaling in epithelial tissue in intestines, prostate and salivary glands. The protein may also be involved in the pathophysiology of depression. [provided by RefSeq, Jun 2016]

GPR39 Products(1)

mRNA Protein Name
NM_001508.3 NP_001499.1 G-protein coupled receptor 39
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
26365466 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPR39 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (59 - 344)

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  • 453 a.a.
Protein Preferred Names Protein Names

G-protein coupled receptor 39

Related Diseases

Diseases Alias
Benign Essential Hypertension
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-103007 TC-G-1008 Agonist 99.61% Unkown
HY-108699 TM-N1324 Agonist 99.91% Unkown
HY-P1306 Obestatin(rat) 98.73% Unkown
HY-P1306A Obestatin(rat) TFA / Unkown
HY-RS05711 GPR39 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris GPR39 VGNC VGNC:41434
Mus musculus GPR39 MGD MGI:1918361
Rattus norvegicus GPR39 RGD RGD:1306745