Fcgr2b - Fc gamma receptor 2B Gene

Rattus norvegicus

Also known as CD32; FCRII; Fcgr2; FcgammaRIIB2

Gene ID: 289211 | Gene type: protein coding

About Fcgr2b

Summary

Enables IgG binding activity. Involved in several processes, including cellular response to amyloid-beta; cellular response to lipopolysaccharide; and negative regulation of neutrophil apoptotic process. Located in cell surface; membrane raft; and recycling endosome. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); dengue disease (multiple); hematologic Cancer (multiple); leukopenia (multiple); and malaria (multiple). Orthologous to several human genes including FCGR2B (Fc fragment of IgG receptor IIb). [provided by Alliance of Genome Resources, Apr 2022]

Fcgr2b Products(1)

mRNA	Protein	Name
NM_175756.3	NP_786932.2	low affinity immunoglobulin gamma Fc region receptor II

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables IgG binding	IDA IDA: Inferred from direct assay	7590913	RGD
enables immunoglobulin binding	IDA IDA: Inferred from direct assay	18295888	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to amyloid-beta	IMP IMP: Inferred from mutant phenotype	23921129	RGD
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	19106808	RGD
involved in endocytic recycling	IDA IDA: Inferred from direct assay	17680646	RGD
involved in immune complex clearance	IDA IDA: Inferred from direct assay	17680646	RGD
involved in negative regulation of neutrophil apoptotic process	IMP IMP: Inferred from mutant phenotype	19106808	RGD
involved in positive regulation of response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	23921129	RGD
involved in receptor-mediated endocytosis	IDA IDA: Inferred from direct assay	17680646	RGD
involved in regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	23921129	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	21774811	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	18295888	RGD
located in recycling endosome	IDA IDA: Inferred from direct assay	17680646	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

low affinity immunoglobulin gamma Fc region receptor II

low affinity immunoglobulin gamma Fc region receptor II-b

FC-gamma RII	Fc fragment of IgG receptor IIb
Fc fragment of IgG, low affinity IIb, receptor	Fc gamma receptor IIb
Fc receptor, IgG, low affinity IIb	igG Fc receptor II beta

Recombinant Fcgr2b Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76235	Fc gamma RIIB/CD32b Protein, Rat (HEK293, His)	Q63203 (H32-P212)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04829	FCGR2B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fcgr2b	NCBI	NCBI:2213
Macaca fascicularis	Fcgr2b	NCBI	NCBI:102139530
Mus musculus	Fcgr2b	NCBI	NCBI:14130

Name
Email *

	Sorry, but the email address you supplied was invalid.