Fcgr2b - Fc receptor, IgG, low affinity IIb Gene

Mus musculus

Also known as CD32; Fcgr2; Fcr-2; Fcr-3; Ly-17; LyM-1; Lym-1; fcRII; FcgRII; Fcgr2a; Ly-m20; Fc[g]RII; F630109E10Rik

Gene ID: 14130 | Gene type: protein coding

About Fcgr2b

Summary

Enables IgG binding activity. Involved in several processes, including cellular response to amyloid-beta; nervous system development; and regulation of cellular response to stress. Acts upstream of or within several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; negative regulation of immune effector process; and regulation of phagocytosis. Located in cell body; dendritic spine; and external side of plasma membrane. Is integral component of membrane. Is expressed in liver and spleen. Used to study malaria and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); dengue disease (multiple); hematologic Cancer (multiple); leukopenia (multiple); and malaria (multiple). Orthologous to several human genes including FCGR2B (Fc fragment of IgG receptor IIb). [provided by Alliance of Genome Resources, Apr 2022]

Fcgr2b Products(2)

mRNA	Protein	Name
NM_001077189.1	NP_001070657.1	low affinity immunoglobulin gamma Fc region receptor II-b isoform 1
NM_010187.2	NP_034317.1	low affinity immunoglobulin gamma Fc region receptor II-b isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables IgG binding	IDA IDA: Inferred from direct assay	9551950	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12893283	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of B cell proliferation	IMP IMP: Inferred from mutant phenotype	12385742	MGI
involved in Fc receptor-mediated immune complex endocytosis	IDA IDA: Inferred from direct assay	28389502	MGI
acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II	IMP IMP: Inferred from mutant phenotype	14643301	MGI
acts upstream of or within cell surface receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	8552190	MGI
involved in cellular response to amyloid-beta	IMP IMP: Inferred from mutant phenotype	23921129	MGI
acts upstream of or within cellular response to molecule of bacterial origin	IMP IMP: Inferred from mutant phenotype	12385742	MGI
involved in cerebellum development	IMP IMP: Inferred from mutant phenotype	17502348	MGI
acts upstream of or within defense response	IMP IMP: Inferred from mutant phenotype	11994421	MGI
involved in dendrite development	IMP IMP: Inferred from mutant phenotype	17502348	MGI
acts upstream of establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	12385742	MGI
acts upstream of or within immunoglobulin mediated immune response	IMP IMP: Inferred from mutant phenotype	10395649	MGI
acts upstream of immunoglobulin production	IMP IMP: Inferred from mutant phenotype	12385742	MGI
acts upstream of interleukin-10 production	IMP IMP: Inferred from mutant phenotype	12385742	MGI
NOT acts upstream of or within mast cell activation	IDA IDA: Inferred from direct assay	8769481	MGI
acts upstream of or within negative regulation of B cell proliferation	IMP IMP: Inferred from mutant phenotype	8552190	MGI
acts upstream of or within negative regulation of acute inflammatory response to antigenic stimulus	IMP IMP: Inferred from mutant phenotype	12385742	MGI
acts upstream of or within negative regulation of humoral immune response mediated by circulating immunoglobulin	IMP IMP: Inferred from mutant phenotype	12385742	MGI
acts upstream of or within negative regulation of immune response	IMP IMP: Inferred from mutant phenotype	8552190	MGI
acts upstream of or within negative regulation of immunoglobulin production	IMP IMP: Inferred from mutant phenotype	12385742	MGI
acts upstream of or within negative regulation of inflammatory response to antigenic stimulus	IMP IMP: Inferred from mutant phenotype	16492738	MGI
acts upstream of or within negative regulation of interleukin-10 production	IMP IMP: Inferred from mutant phenotype	12385742	MGI
acts upstream of or within negative regulation of phagocytosis	IMP IMP: Inferred from mutant phenotype	12385742	MGI
acts upstream of or within negative regulation of type I hypersensitivity	IMP IMP: Inferred from mutant phenotype	8552190	MGI
acts upstream of phagocytosis	IMP IMP: Inferred from mutant phenotype	12385742	MGI
acts upstream of or within phagocytosis, engulfment	IDA IDA: Inferred from direct assay	8769481	MGI
involved in positive regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	23921129	MGI
involved in positive regulation of JNK cascade	IMP IMP: Inferred from mutant phenotype	23921129	MGI
acts upstream of or within positive regulation of phagocytosis	IDA IDA: Inferred from direct assay	8769481	MGI
involved in positive regulation of response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	23921129	MGI
involved in regulation of dendritic spine maintenance	IMP IMP: Inferred from mutant phenotype	23921129	MGI
involved in regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	23921129	MGI
involved in regulation of long-term neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	23921129	MGI
acts upstream of or within response to bacterium	IMP IMP: Inferred from mutant phenotype	12385742	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell body	IDA IDA: Inferred from direct assay	17502348	MGI
located in dendritic spine	IDA IDA: Inferred from direct assay	17502348	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	8552190	MGI
located in membrane	IDA IDA: Inferred from direct assay	8552190	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	17502348	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

low affinity immunoglobulin gamma Fc region receptor II-b

Fc gamma RIIB	Fc-gamma-RII
FcgammaRIIB	fc gamma receptor IIB
fc-gamma RII	fc-gamma-RIIB
igG Fc receptor II beta	low affinity immunoglobulin gamma Fc region receptor II
lymphocyte antigen 17

Recombinant Fcgr2b Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72735	Fc gamma RIIB/CD32b Protein, Mouse (HEK293, His)	P08101 (T30-P210)	≥95%
HY-P75649	Fc gamma RIIB/CD32b Protein, Mouse (Biotinylated, HEK293, His-Avi)	A0A0B4J1E6/NP_001070657 (M1-R217)	≥95%

Fcgr2b Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83712m	Rat Anti-Mouse CD16/32 Antibody (FITC)	FC	Mouse

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04829	FCGR2B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fcgr2b	NCBI	NCBI:2213
Macaca fascicularis	Fcgr2b	NCBI	NCBI:102139530
Rattus norvegicus	Fcgr2b	NCBI	NCBI:289211

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