FCGR2B - Fc gamma receptor IIb Gene

Homo sapiens

Also known as CD32; FCG2; CD32B; FCGR2; IGFR2; FCGR2C; FcGRIIB; FcRII-c; FcgammaRIIb

Gene ID: 2213 | Gene type: protein coding

About FCGR2B

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:161,647,243-161,678,654 (from NCBI)

This gene has 6 transcripts (splice variants), 264 orthologues, 17 paralogues and is associated with 55 phenotypes. Biased expression in placenta (RPKM 92.9), appendix (RPKM 9.6) and 6 other tissues.

Summary

The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

FCGR2B Products(13)

mRNA	Protein	Name
NM_001002273.3	NP_001002273.1	low affinity immunoglobulin gamma Fc region receptor II-b isoform 2 precursor
NM_001002274.3	NP_001002274.1	low affinity immunoglobulin gamma Fc region receptor II-b isoform 3 precursor
NM_001002275.3	NP_001002275.1	low affinity immunoglobulin gamma Fc region receptor II-b isoform 4 precursor
NM_001190828.2	NP_001177757.1	low affinity immunoglobulin gamma Fc region receptor II-b isoform 5
NM_001386000.1	NP_001372929.1	low affinity immunoglobulin gamma Fc region receptor II-b isoform 6
NM_001386001.1	NP_001372930.1	low affinity immunoglobulin gamma Fc region receptor II-b isoform 7
NM_001386002.1	NP_001372931.1	low affinity immunoglobulin gamma Fc region receptor II-b isoform 8
NM_001386003.1	NP_001372932.1	low affinity immunoglobulin gamma Fc region receptor II-b isoform 9 precursor
NM_001386004.1	NP_001372933.1	low affinity immunoglobulin gamma Fc region receptor II-b isoform 10
NM_001386005.1	NP_001372934.1	low affinity immunoglobulin gamma Fc region receptor II-b isoform 11 precursor
NM_001386006.1	NP_001372935.1	low affinity immunoglobulin gamma Fc region receptor II-b isoform 12
NM_001394477.1	NP_001381406.1	low affinity immunoglobulin gamma Fc region receptor II-b isoform 1 precursor
NM_004001.5	NP_003992.3	low affinity immunoglobulin gamma Fc region receptor II-b isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables IgG binding	IDA IDA: Inferred from direct assay	2142460	GOA
enables amyloid-beta binding	IPI IPI: Inferred from physical interaction	23921129	GOA
enables low-affinity IgG receptor activity	IDA IDA: Inferred from direct assay	2142460	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8577729	GOA
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	23921129	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Fc-gamma receptor signaling pathway	IDA IDA: Inferred from direct assay	2142460	GOA
involved in immune effector process	IDA IDA: Inferred from direct assay	2142460	GOA
involved in negative regulation of B cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	24169826	GOA
involved in phagocytosis	IDA IDA: Inferred from direct assay	2142460	GOA
involved in receptor-mediated endocytosis	IDA IDA: Inferred from direct assay	2142460	GOA
involved in regulation of dendritic spine maintenance	IGI IGI: Inferred from genetic interaction	23921129	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	2142460	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FCGR2B Protein Structure

Ig_2

0
100
200
310 a.a.

Protein Preferred Names

Protein Names

low affinity immunoglobulin gamma Fc region receptor II-b

CDw32

Recombinant FCGR2B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70491	Fc gamma RIIB/CD32b Protein, Human (HEK293, His)	P31994-1 (T43-P217)	≥95%
HY-P75211	Fc gamma RIIB/CD32b Protein, Human (Biotinylated, HEK293, His-Avi)	P31994-2/NP_001002274.1 (A46-I224)	≥95%
HY-P78424	Fc gamma RIIB/CD32b Protein, Human (HEK293, His-Avi)	P31994-1 (A46-P217)	≥95%

Related Diseases

Diseases

Alias

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Malaria

Malaria, Susceptibility To	Malaria, Resistance To
Malaria, Cerebral	Cerebral Malaria
Malaria, Severe, Susceptibility To	Malaria, Severe, Resistance To
Malaria, Cerebral, Susceptibility To	Induced Malaria
Malaria, Vivax, Protection Against	Malaria, Severe
Malaria, Cerebral, Reduced Risk Of	Malaria, Protection Against
Resistance To Malaria Due To G6pd Deficiency	Malaria Due To G6pd Deficiency
Malarial Encephalitis	CM
Malaria Cerebral	Susceptibility To Malaria
Acute Pernicious Fever	Aestivo-Autumnal Fever
Aestivo Autumnal Malaria	Chagres Fever
Continued Malaria Fever	Estivo-Autumnal Fever
Estivo-Autumnal Malaria	Estivo-Autumnal Malarial Fever
Falciparum Fever	Malignant Tertian Fever
Malignant Tertian Malaria	Pernicious Intermittent Fever
Pernicious Malaria	Quotidian Malaria
Subtertian Fever	Subtertian Malaria Fever
Subtertian Malignant Tertian Malaria	Tropical Malaria
Algid Malaria	Bilious Haemoglobinuric Fever
Black Water Fever	Blackwater Fever
Malarial Blackwater Fever	Severe Malarial Falciparum
West African Fever	Malarial Haematinuria
Haemoglobinuric Fever	Haemoglobinuric Malaria
Severe Plasmodium Falciparum Malaria	Malarial Haemoglobinuria
Malarial Haematuria	Falciparum Malaria [Malignant Tertian]
Malaria Tropica	Malarial Shock
Chagres Virus Disease	Malignant Malaria
Mtm - [Malignant Tertian Malaria]	Tm -[Malignant Tertian Malaria]
Panama Fever	St - [Subtertian Malaria]
Malarial Quotidian	Benign Tertian Malaria
Tertian Ague	Vivax Fever
Plasmodium Vivax Malaria Nos	Btm - [Benign Tertian Malaria]
Bt - [Benign Tertian Malaria]	Vivax Malaria
Benign Tertian Vivax Malaria	Tertian Malaria
Quartan Malaria	Quartan Ague
Quartan Fever	Plasmodium Malariae Malaria Nos
Quartan Malarial	Malaria By Plasmodium Malariae
Malariae Malaria	Ovale Tertian Malaria
Plasmodium Ovale Fever	Malaria Fever By Plasmodium Ovale
Ovale Malaria	Malaria By Plasmodium Ovale
Malarial Ovale	Marsh Fever
Remittent Congestive Fever	Coastal Fever
Remittent Gastric Fever	Miasmatic Fever
Congestive Remittent Fever	Intermittent Fever
Jungle Fever	Paludism
Cameroon Fever	Ague
Corsican Fever	Intermittent Bilious Fever
Disease Due To Plasmodiidae	Malarial Fever
Plasmodiosis	Remittent Fever
Roman Fever	Malaria Fever Nos
Malaria Nos	Paludal Fever
Clinically Diagnosed Malaria	Clinically Diagnosed Malaria Without Parasitological Confirmation
Congestive Fever	Malarial Cachexia
Marsh Cachexia	Paludal Cachexia
Recurrent Malaria	Remittent Malaria

Lupus Erythematosus

Lupus	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus, Systemic
Subacute Cutaneous Lupus	Le - [Lupus Erythematosus]

Measles

Rubeola	Morbilli
Measles Nos	Koplik Spots

Autoimmune Disease

Autoimmune Diseases	Autoimmune Hypersensitivity Disease
Hypersensitivity Reaction Type Ii Disease	Type Ii Hypersensitivity Reaction Disease

Mast Cell Neoplasm

Mastocytoma	Mast Cell Proliferative Disease
Mast Cell Tumor	Benign Mastocytoma

Autoimmune Glomerulonephritis

Lymphoma

Lymphoid Cancer	Lymphomas
Lymphoid Cancers	Lymphoid Neoplasm
Lymphoma Nos	Nhl - [Non-Hodgkin Lymphoma]
Non-Hodgkin Lymphoma	Non-Hodgkin Lymphoma, Nos
Non-Hodgkin Malignant Lymphoma Nos

Follicular Lymphoma

Lymphoma, Follicular	Lymphoma Follicular
Brill-Symmers' Disease	Large Cell Follicular Non-Hodgkin Lymphoma
Diffuse Follicle Centre Lymphoma	Diffuse Follicular Lymphoma Nos
Follicular Nodular Non-Hodgkin Lymphoma, Unspecified	Follicular Large Cell Cleaved Or Noncleaved Lymphoma
Large Cell Follicular Noncleaved Lymphoma	Follicular Lymphoma With Or Without Diffuse Areas
Histiocytic Follicular Lymphoma	Histiocytic Nodular Lymphoma
Histiocytic Nodular Malignant Lymphoma	Large Cell Follicular Lymphoma
Large Cell Noncleaved Follicular Lymphoma	Large Cell Noncleaved Follicular Malignant Lymphoma
Nodular Reticulum Cell Sarcoma	Noncleaved Follicular Lymphoma

Autoimmune Disease Of Urogenital Tract

Arthus Reaction

Arthus Phenomenon

Arthus Type Urticaria

B-Cell Lymphoma

Lymphoma, B-Cell	B-Cell Lymphomas
B-Cell Lymphocytic Neoplasm	Lymphoma B-Cell
B-Cell Lymphoma Nos

Anti-Basement Membrane Glomerulonephritis

Anti-Gbm Glomerulonephritis

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Primary Thrombocytopenia

Common Variable Immunodeficiency

Cvid	Common Variable Agammaglobulinemia
Common Variable Immune Deficiency	Acquired Hypogammaglobulinemia
Hypogamma-Globulinemia, Acquired	Idiopathic Immunoglobulin Deficiency
Primary Antibody Deficiency	Primary Hypogammaglobulinemia
Acquired Agammaglobulinemia	Sporadic Hypogammaglobulinemia
Common Variable Hypogamma-Globulinemia	Immunoglobulin Deficiency, Late-Onset
Common Variable Hypogammaglobulinemia	Immunodeficiency, Common Variable

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Thrombocytopenia Due To Platelet Alloimmunization

Immune Thrombocytopenia	Autoimmune Thrombocytopenia
Immune Thrombocytopenic Purpura	Itp
Auto-Immune Thrombocytopenia	Thrombocytopenia Due To Immune Destruction
Autoimmune Thrombocytopenic Purpura	Idiopathic Thrombocytopenic Purpura
Werlhof Disease

Goodpasture Syndrome

Anti-Glomerular Basement Membrane Disease	Anti-Gbm Disease
Pulmonary Renal Syndrome	Anti-Glomerular Basement Membrane Antibody Disease
Glomerulonephritis - Pulmonary Hemorrhage	Rapidly Progressive Glomerulonephritis With Pulmonary Hemorrhage
Anti-Gbm Syndrome	Goodpasture'S Syndrome
Anti-Basement Membrane Glomerulonephritis

Demyelinating Polyneuropathy

Peripheral Demyelinating Neuropathy

Demyelinating Peripheral Neuropathy

Thrombocytopenic Purpura, Autoimmune

Idiopathic Thrombocytopenic Purpura	Autoimmune Thrombocytopenic Purpura
Immune Thrombocytopenic Purpura	Itp
Idiopathic Purpura	AITP
Ideopath Thrombocytopenic Pur	Primary Thrombocytopenic Purpura
Werlhof'S Disease	Thrombocytopenic Purpura Autoimmune
Purpura Thrombocytopenic Idiopathic	Purpura, Thrombocytopenic, Idiopathic
Autoimmune Thrombocytopenia	Thrombocytopenia Due To Platelet Alloimmunization
Idiopathic Thrombocytopenia	Idiopathic Thrombocytopenia Purpura
Frank'S Essential Thrombocytopenia	Itp - [Idiopathic Thrombocytopenia Purpura]
Werlhof Disease	Primary Autoimmune Thrombocytopenic Purpura
Haemorrhagic Purpura	Essential Thrombocytopenia
Purpura Haemorrhagica

Autoimmune Neuropathy

Hypersensitivity Reaction Type Iii Disease

Immune Complex Diseases	Immune Complex Disease
Type Iii Hypersensitivity Reaction Disease

Autoimmune Disease Of Blood

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04829	FCGR2B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FCGR2B	MGD	MGI:95499
Rattus norvegicus	FCGR2B	RGD	RGD:631331
Macaca fascicularis	FCGR2B	NCBI	NCBI:102139530

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