SLC43A3 - solute carrier family 43 member 3 Gene

Homo sapiens

Also known as EEG1; ENBT1; FOAP-13; PRO1659; SEEEG-1

Gene ID: 29015 | Gene type: protein coding

About SLC43A3

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:57,406,954-57,427,580 (from NCBI)

This gene has 26 transcripts (splice variants) and 282 orthologues. Ubiquitous expression in thyroid (RPKM 33.1), liver (RPKM 25.7) and 24 other tissues.

Summary

Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

SLC43A3 Products(5)

mRNA	Protein	Name
NM_001278201.2	NP_001265130.1	equilibrative nucleobase transporter 1 isoform 1
NM_001278206.2	NP_001265135.1	equilibrative nucleobase transporter 1 isoform 2
NM_014096.4	NP_054815.2	equilibrative nucleobase transporter 1 isoform 1
NM_017611.3	NP_060081.1	equilibrative nucleobase transporter 1 isoform 1
NM_199329.3	NP_955361.1	equilibrative nucleobase transporter 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables adenine transmembrane transporter activity	IDA IDA: Inferred from direct assay	26455426	GOA
enables guanine transmembrane transporter activity	IDA IDA: Inferred from direct assay	26455426	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA
enables xenobiotic transmembrane transporter activity	IDA IDA: Inferred from direct assay	30910793	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in hypoxanthine transport	IDA IDA: Inferred from direct assay	26455426	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	26455426	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC43A3 Protein Structure

MFS_1

0
100
200
300
400
491 a.a.

Protein Preferred Names

Protein Names

equilibrative nucleobase transporter 1

likely ortholog of mouse embryonic epithelial gene 1

SLC43A3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SLC43A3	Q8NBI5	VCP	Homo sapiens	P55072	Y2H Pooling	32814053
Intra	SLC43A3	Q8NBI5	VCP	Homo sapiens	P55072	Validated Y2H	32814053
Intra	SLC43A3	Q8NBI5	VCP	Homo sapiens	P55072	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Ovarian Angiosarcoma

Hemangiosarcoma Of Ovary

Thiamine-Responsive Megaloblastic Anemia Syndrome

TRMA	Rogers Syndrome
Thiamine-Responsive Myelodysplasia	Thiamine-Responsive Anemia Syndrome
Thiamine Metabolism Dysfunction Syndrome 1	Thmd1
Megaloblastic Anemia, Thiamine-Responsive, With Diabetes Mellitus And Sensorineural Deafness	Thiamine-Responsive Megaloblastic Anemia With Diabetes Mellitus And Sensorineural Deafness
Thiamine Responsive Megaloblastic Anemia Syndrome	Megaloblastic Anemia Thiamine-Responsive With Diabetes Mellitus And Sensorineural Deafness
Thiamine-Responsive Megaloblastic Anemia	Thiamine-Responsive Anaemia Syndrome
Thiamine-Responsive Megaloblastic Anaemia Syndrome	Thiamine-Responsive Megaloblastic Anaemia With Diabetes Mellitus And Sensorineural Deafness
Thiamine-Responsive Megaloblastic Anemia With Diabetes Mellitus And Sensorineural Hearing Loss

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13250	SLC43A3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SLC43A3	VGNC	VGNC:54892
Mus musculus	SLC43A3	MGD	MGI:1931054
Canis familiaris	SLC43A3	VGNC	VGNC:49711
Felis catus	SLC43A3	VGNC	VGNC:81936
Macaca mulatta	SLC43A3	VGNC	VGNC:108151
Rattus norvegicus	SLC43A3	RGD	RGD:1312016

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