1. Gene
  2. WDR91 - WD repeat domain 91 Gene

WDR91 - WD repeat domain 91 Gene

Homo sapiens

Also known as SORF1; SORF-1; HSPC049

Gene ID: 29062 | Gene type: protein coding

About WDR91

Cytogenetic location: 7q33 Genomic coordinates (GRCh38): 7:135,183,839-135,211,526 (from NCBI)

This gene has 21 transcripts (splice variants) and 204 orthologues. Ubiquitous expression in kidney (RPKM 8.1), placenta (RPKM 7.8) and 25 other tissues.

Summary

Enables phosphatidylinositol 3-kinase regulator activity. Involved in early endosome to late endosome transport; regulation of cellular protein catabolic process; and regulation of phosphatidylinositol 3-kinase activity. Located in cytosol; early endosome membrane; and late endosome membrane. Is extrinsic component of endosome membrane. [provided by Alliance of Genome Resources, Apr 2022]

WDR91 Products(4)

mRNA Protein Name
NM_001362736.2 NP_001349665.1 WD repeat-containing protein 91 isoform 2
NM_001362737.2 NP_001349666.1 WD repeat-containing protein 91 isoform 1
NM_001362738.2 NP_001349667.1 WD repeat-containing protein 91 isoform 4
NM_014149.4 NP_054868.3 WD repeat-containing protein 91 isoform 3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables phosphatidylinositol 3-kinase inhibitor activity IMP
IMP: Inferred from mutant phenotype
26783301 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17500595 GOA
Biological Process GO Annotation Evidence Reference Source
involved in early endosome to late endosome transport IMP
IMP: Inferred from mutant phenotype
26783301 GOA
involved in regulation of protein catabolic process IMP
IMP: Inferred from mutant phenotype
27126989 GOA
NOT involved in ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
28404643 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytosol IDA
IDA: Inferred from direct assay
26783301 GOA
located in early endosome membrane IDA
IDA: Inferred from direct assay
26783301 GOA
located in endosome membrane IDA
IDA: Inferred from direct assay
26783301 GOA
located in late endosome membrane IDA
IDA: Inferred from direct assay
26783301 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WDR91 Protein Structure

WD40

WD40: WD domain, G-beta repeat (404 - 436)

WD40

WD40: WD domain, G-beta repeat (564 - 590)

WD40

WD40: WD domain, G-beta repeat (595 - 632)

WD40

WD40: WD domain, G-beta repeat (706 - 739)

  • 0
  • 200
  • 400
  • 600
  • 747 a.a.
Protein Preferred Names Protein Names

WD repeat-containing protein 91

WDR91 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra WDR91 A4D1P6 HTT Homo sapiens P42858
Validated Y2H
32814053
Intra WDR91 A4D1P6 HTT Homo sapiens P42858
Y2H Pooling
32814053
Intra WDR91 A4D1P6 HTT Homo sapiens P42858
Y2H Array
32814053
Intra WDR91 A4D1P6 WDR81 Homo sapiens Q562E7
Anti Tag CoIP
26783301
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Laryngotracheitis
Cerebellar Ataxia, Mental Retardation, And Dysequilibrium Syndrome 1

Dysequilibrium Syndrome

CAMRQ1

Des

Cerebellar Ataxia, Intellectual Disability, And Dysequilibrium Syndrome 1

Cerebellar Hypoplasia, Vldlr-Associated

Cerebellar Hypoplasia And Mental Retardation With Or Without Quadrupedal Locomotion 1

Cerebellar Ataxia, Mental Retardation And Dysequlibrium Syndrome

Uner Tan Syndrome

Vldlr Cerebellar Hypoplasia

Vldlrch

Vldlr-Associated Cerebellar Hypoplasia

Cerebellar Ataxia And Mental Retardation With Or Without Quadrupedal Locomotion 1

Cerebellar Ataxia, Congenital, And Mental Retardation, Autosomal Recessive

Camrq

Cerebellar Ataxia, Mental Retardation, Dysequilibrium Syndrome 1

Cerebellar Disorder, Nonprogressive, With Intellectual Disability

Cerebellar Hypoplasia, Vldlr Associated

Autosomal Recessive Cerebellar Ataxia With Mental Retardation

Autosomal Recessive Cerebellar Hypoplasia With Cerebral Gyral Simplification

Cerebellar Disorder, Nonprogressive, With Mental Retardation

Cerebellar Hypoplasia And Mental Retardation With Or Without Quadrupedal Locomotion

Chmrq1

Des-Vldlr

Dysequilibrium Syndrome-Vldlr

Vldlr-Ch

Camrq Syndrome

Cerebellar Ataxia-Intellectual Disability-Dysequilibrium Syndrome Syndrome

Non-Progressive Cerebellar Ataxia-Intellectual Disability Syndrome

Uts

Cerebellar Hypoplasia Vldlr-Associated

Dialysis Disequilibrium Syndrome

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta WDR91 VGNC VGNC:79464
Mus musculus WDR91 MGD MGI:2141558
Rattus norvegicus WDR91 RGD RGD:1306697
Canis familiaris WDR91 VGNC VGNC:48398
Bos taurus WDR91 VGNC VGNC:36927
Felis catus WDR91 VGNC VGNC:67063