THYN1 - thymocyte nuclear protein 1 Gene

Homo sapiens

Also known as MY105; THY28; MDS012; HSPC144; THY28KD

Gene ID: 29087 | Gene type: protein coding

About THYN1

Cytogenetic location: 11q25 Genomic coordinates (GRCh38): 11:134,248,282-134,253,352 (from NCBI)

This gene has 8 transcripts (splice variants) and 200 orthologues. Ubiquitous expression in thyroid (RPKM 21.0), ovary (RPKM 20.9) and 25 other tissues.

Summary

This gene encodes a protein that is highly conserved among vertebrates and plant species and may be involved in the induction of Apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

THYN1 Products(5)

mRNA	Protein	Name
NM_001037304.2	NP_001032381.1	thymocyte nuclear protein 1 isoform 2
NM_001037305.2	NP_001032382.1	thymocyte nuclear protein 1 isoform 1
NM_014174.3	NP_054893.1	thymocyte nuclear protein 1 isoform 1
NM_199297.2	NP_954994.1	thymocyte nuclear protein 1 isoform 2
NM_199298.2	NP_954995.1	thymocyte nuclear protein 1 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

THYN1 Protein Structure

EVE

0
100
200
225 a.a.

Protein Preferred Names

Protein Names

thymocyte nuclear protein 1

thymocyte protein thy28

THYN1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	THYN1	Q9P016	SHPK	Homo sapiens	Q9UHJ6	Anti Tag CoIP	33961781
Intra	THYN1	Q9P016	SHPK	Homo sapiens	Q9UHJ6	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Jacobsen Syndrome

Chromosome 11q Deletion Syndrome	Partial 11q Monosomy Syndrome
Jacobsen Distal 11q Deletion Syndrome	JBS
11q Partial Monosomy Syndrome	Chromosome 11q Deletion
11q Deletion	11q Monosomy
Deletion 11q	Monosomy 11q
Partial Monosomy 11q	11q Deletion Disorder
11q Deletion Syndrome	11q Terminal Deletion Disorder
11q- Deletion Syndrome	11q23 Deletion Disorder
Jacobsen Thrombocytopenia	11q Terminal Deletion Syndrome
Del(11)(Q23.3)	Del(11)(Qter)
Distal Deletion 11q	Distal Monosomy 11q
Monosomy 11qter	Telomeric Deletion 11q
Paris-Trousseau Thrombocytopenia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14512	THYN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	THYN1	RGD	RGD:1359525
Canis familiaris	THYN1	VGNC	VGNC:53457
Bos taurus	THYN1	VGNC	VGNC:35857
Mus musculus	THYN1	MGD	MGI:1925112
Felis catus	THYN1	VGNC	VGNC:103752
Macaca mulatta	THYN1	VGNC	VGNC:110528

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