MRPL15 - mitochondrial ribosomal protein L15 Gene

Homo sapiens

Also known as L15mt; RPML7; MRP-L7; HSPC145; MRP-L15

Gene ID: 29088 | Gene type: protein coding

About MRPL15

Cytogenetic location: 8q11.23 Genomic coordinates (GRCh38): 8:54,135,241-54,148,514 (from NCBI)

This gene has 3 transcripts (splice variants) and 219 orthologues. Ubiquitous expression in heart (RPKM 21.7), kidney (RPKM 16.2) and 25 other tissues.

Summary

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the EcoL15 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 15q. [provided by RefSeq, Jul 2008]

MRPL15 Products(1)

mRNA	Protein	Name
NM_014175.4	NP_054894.1	39S ribosomal protein L15, mitochondrial

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21516116	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of mitochondrial large ribosomal subunit	IDA IDA: Inferred from direct assay	25278503	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	28892042	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MRPL15 Protein Structure

Ribosomal_L27A

0
100
200
296 a.a.

Protein Preferred Names

Protein Names

39S ribosomal protein L15, mitochondrial

mitochondrial large ribosomal subunit protein uL15m

Related Diseases

Diseases

Alias

Exposure Keratitis

Exposure Keratoconjunctivitis

Lagophthalmic Keratitis

Lagophthalmos

Defective Lid Closure

Poor Closure Eyelids

Lymphatic Malformation 5

Meige Syndrome	Meige Disease
Meige Lymphedema	Lymphedema Praecox
Lymphedema, Late-Onset	Late-Onset Lymphedema
LMPH2	Meigs Syndrome
LMPHM5	Lymphedema, Hereditary, Ii, Formerly
Lmph2, Formerly	Hereditary Lymphedema Ii
Demons-Meigs Syndrome	Hereditary Lymphedema Type Ii
Lymphedema, Hereditary, 2	Lymphedema, Hereditary, Ii
Meige'S Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08664	MRPL15 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MRPL15	VGNC	VGNC:81708
Canis familiaris	MRPL15	VGNC	VGNC:43380
Bos taurus	MRPL15	VGNC	VGNC:31619
Rattus norvegicus	MRPL15	RGD	RGD:1304796
Mus musculus	MRPL15	MGD	MGI:1351639
Macaca mulatta	MRPL15	VGNC	VGNC:74745

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