N6AMT1 - N-6 adenine-specific DNA methyltransferase 1 Gene

Homo sapiens

Also known as KMT9; MTQ2; PrmC; HEMK2; N6AMT; PRED28; C21orf127; m.HsaHemK2P

Gene ID: 29104 | Gene type: protein coding

About N6AMT1

Cytogenetic location: 21q21.3 Genomic coordinates (GRCh38): 21:28,575,598-28,885,367 (from NCBI)

This gene has 3 transcripts (splice variants), 197 orthologues and 2 paralogues. Ubiquitous expression in prostate (RPKM 1.2), ovary (RPKM 1.0) and 25 other tissues.

Summary

This gene encodes an N(6)-adenine-specific DNA Methyltransferase. The encoded Enzyme may be involved in the methylation of release factor I during translation termination. This Enzyme is also involved in converting the arsenic metabolite monomethylarsonous acid to the less toxic dimethylarsonic acid. Alternative splicing pf this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Jul 2014]

N6AMT1 Products(2)

mRNA	Protein	Name
NM_013240.6	NP_037372.4	methyltransferase N6AMT1 isoform 1
NM_182749.5	NP_877426.4	methyltransferase N6AMT1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables S-adenosyl-L-methionine binding	IDA IDA: Inferred from direct assay	31636962	GOA
enables arsenite methyltransferase activity	IDA IDA: Inferred from direct assay	25997655	GOA
enables histone H4K12 methyltransferase activity	IDA IDA: Inferred from direct assay	31061526	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18539146	GOA
enables protein methyltransferase activity	IDA IDA: Inferred from direct assay	18539146	GOA
enables protein-glutamine N-methyltransferase activity	IDA IDA: Inferred from direct assay	18539146	GOA
NOT enables site-specific DNA-methyltransferase (adenine-specific) activity	IDA IDA: Inferred from direct assay	30392959	GOA
enables site-specific DNA-methyltransferase (adenine-specific) activity	IDA IDA: Inferred from direct assay	30017583	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in arsonoacetate metabolic process	IDA IDA: Inferred from direct assay	25997655	GOA
involved in methylation	IDA IDA: Inferred from direct assay	25997655	GOA
involved in negative regulation of gene expression, epigenetic	IDA IDA: Inferred from direct assay	30017583	GOA
involved in peptidyl-glutamine methylation	IDA IDA: Inferred from direct assay	18539146	GOA
acts upstream of or within positive regulation of cell growth	IDA IDA: Inferred from direct assay	18539146	GOA
involved in toxin metabolic process	IDA IDA: Inferred from direct assay	25997655	GOA
involved in transcription initiation-coupled chromatin remodeling	IDA IDA: Inferred from direct assay	31061526	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of protein-containing complex	IDA IDA: Inferred from direct assay	18539146	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

N6AMT1 Protein Structure

0
100
200
214 a.a.

Protein Preferred Names

Protein Names

methyltransferase N6AMT1

HemK methyltransferase family member 2

Recombinant N6AMT1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77376	HEMK2 Protein, Human (His)	Q9Y5N5-2 (M1-S186)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08984	N6AMT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	N6AMT1	VGNC	VGNC:63703
Rattus norvegicus	N6AMT1	RGD	RGD:1311843
Canis familiaris	N6AMT1	VGNC	VGNC:59066
Mus musculus	N6AMT1	MGD	MGI:1915018
Bos taurus	N6AMT1	VGNC	VGNC:49558
Others	N6AMT1	NCBI

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