CXCL3 - C-X-C motif chemokine ligand 3 Gene

Homo sapiens

Also known as GRO3; GROg; MIP2B; SCYB3; MIP-2b; CINC-2b

Gene ID: 2921 | Gene type: protein coding

About CXCL3

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:74,036,589-74,038,689 (from NCBI)

This gene has 4 transcripts (splice variants), 13 orthologues and 12 paralogues. Biased expression in appendix (RPKM 8.6), bone marrow (RPKM 6.3) and 12 other tissues.

Summary

This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. [provided by RefSeq, Sep 2014]

CXCL3 Products(1)

mRNA	Protein	Name
NM_002090.3	NP_002081.2	C-X-C motif chemokine 3 precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: Inferred from direct assay	12949249	GOA
involved in killing of cells of another organism	IDA IDA: Inferred from direct assay	12949249	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	10095777	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CXCL3 Protein Structure

IL8

0
100
107 a.a.

Protein Preferred Names

Protein Names

C-X-C motif chemokine 3

GRO-gamma

Recombinant CXCL3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7192	GRO-gamma/CXCL3 Protein, Human (CHO)	P19876 (A35-N107)	≥95%
HY-P7193	GRO-gamma/CXCL3 Protein, Human	P19876 (A35-N107)	≥95%
HY-P72678	GRO-gamma/CXCL3 Protein, Human (His)	P19876 (A35-N107)	≥95%
HY-P72678AF	Animal-Free GRO-gamma/CXCL3 Protein, Human (His)	P19876 (A35-N107)	≥95%

Related Diseases

Diseases

Alias

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03392	CXCL3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CXCL3	NCBI	NCBI:330122
Rattus norvegicus	CXCL3	NCBI	NCBI:171551
Others	CXCL3	NCBI

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