Gpi - glucose-6-phosphate isomerase Gene

Rattus norvegicus

Also known as Amf; Nlk; Pgi; Phi; Gpi1

Gene ID: 292804 | Gene type: protein coding

About Gpi

Summary

This gene encodes a member of the glucose phosphate isomerase protein family. A similar protein in human and mouse has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic Enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phophsate and fructose-6-phosphate. Extracellularly, the protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. [provided by RefSeq, Jan 2014]

Gpi Products(1)

mRNA	Protein	Name
NM_207592.1	NP_997475.1	glucose-6-phosphate isomerase

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables glucose-6-phosphate isomerase activity	IDA IDA: Inferred from direct assay	1834654	RGD
enables monosaccharide binding	IPI IPI: Inferred from physical interaction	2709006	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in glucose 6-phosphate metabolic process	IDA IDA: Inferred from direct assay	2709006	RGD
involved in learning or memory	IEP IEP: Inferred from expression pattern	11902125	RGD
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	12615053	RGD
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	12615053	RGD
involved in response to cadmium ion	IEP IEP: Inferred from expression pattern	10536756	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	1501493	RGD
involved in response to immobilization stress	IEP IEP: Inferred from expression pattern	8927521	RGD
involved in response to muscle stretch	IEP IEP: Inferred from expression pattern	8927521	RGD
involved in response to progesterone	IEP IEP: Inferred from expression pattern	1501493	RGD
involved in response to testosterone	IEP IEP: Inferred from expression pattern	4002659	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

glucose-6-phosphate isomerase

autocrine motility factor

Related Agents

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P2918	Phosphoglucose Isomerase, Rabbit muscle		/	Phase 4
HY-136424	GPI-1485		99.88%	Phase 2
HY-18233	Manogepix	Inhibitor	99.85%	Phase 1

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99006	Amatuximab	Inhibitor	99.90%	Phase 2

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108615	CP-316819	Inhibitor	≥99.0%	Unkown
HY-103345	2-MPPA	Inhibitor	≥98.0%	Unkown
HY-129035	PFI-653	Inhibitor	99.92%	Unkown
HY-124619	GPI-1046	Inhibitor	99.74%	Unkown
HY-19396	Ingliforib	Inhibitor	99.07%	Unkown
HY-147110	APX2039	Inhibitor	98.12%	Unkown
HY-131455A	Biotin-C1-PEG3-C3-amido-C5-Gly-Arg-Gly-N3 TFA		≥98.0%	Unkown
HY-13540	E7016	Inhibitor	98.46%	Unkown
HY-P1596	Gluten Exorphin C	Inhibitor	99.86%	Unkown
HY-108614	GPi688	Inhibitor	/	Unkown
HY-145316	Vanin-1-IN-2	Inhibitor	/	Unkown
HY-15048	GPI 15427	Inhibitor	/	Unkown
HY-164813	oxLig-1	Activator	/	Unkown
HY-P3632	[DAla2, DArg6] Dynorphin A, (1-13) (porcine)		/	Unkown
HY-P3809	[D-Pro2,D-Phe7,D-Trp9] Substance P		/	Unkown
HY-RS05639	GPI Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gpi	NCBI	NCBI:2821
Canis familiaris	Gpi	NCBI	NCBI:611942
Macaca fascicularis	Gpi	NCBI	NCBI:101865104
Mus musculus	Gpi	NCBI
Macaca mulatta	Gpi	NCBI	NCBI:717980

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