Sgk1 - serum/glucocorticoid regulated kinase 1 Gene

Rattus norvegicus

Also known as Sgk

Gene ID: 29517 | Gene type: protein coding

About Sgk1

Primary_assembly 1: 22,980,261-23,098,283 reverse strand.mRatBN7.2:CM026974.1

This gene has 4 transcripts (splice variants), 214 orthologues, 13 paralogues and is associated with 12 phenotypes. Biased expression in Kidney (RPKM 287.7), Thymus (RPKM 277.9) and 9 other tissues.

Summary

Enables 3-phosphoinositide-dependent protein kinase binding activity; protein serine/threonine kinase activity; and Tau Protein binding activity. Involved in several processes, including generation of neurons; glucocorticoid mediated signaling pathway; and learning or memory. Acts upstream of or within cellular response to Insulin stimulus; positive regulation of sodium ion transport; and regulation of protein localization. Located in neuron projection; nucleus; and perinuclear region of cytoplasm. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human SGK1 (serum/glucocorticoid regulated kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Sgk1 Products(3)

mRNA	Protein	Name
NM_001193568.1	NP_001180497.1	serine/threonine-protein kinase Sgk1 isoform 1
NM_001193569.1	NP_001180498.1	serine/threonine-protein kinase Sgk1 isoform 2
NM_019232.3	NP_062105.2	serine/threonine-protein kinase Sgk1 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 3-phosphoinositide-dependent protein kinase binding	IPI IPI: Inferred from physical interaction	10357815	RGD
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	16982696	RGD
enables tau protein binding	IPI IPI: Inferred from physical interaction	16982696	RGD

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cellular response to insulin stimulus	IMP IMP: Inferred from mutant phenotype	17715136	RGD
involved in intracellular sodium ion homeostasis	IDA IDA: Inferred from direct assay	11250940	RGD
involved in long-term memory	IMP IMP: Inferred from mutant phenotype	11891330	RGD
involved in microtubule depolymerization	IDA IDA: Inferred from direct assay	16982696	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	15795328	RGD
involved in negative regulation of microtubule polymerization	IDA IDA: Inferred from direct assay	16982696	RGD
involved in neuron projection morphogenesis	IDA IDA: Inferred from direct assay	16982696	RGD
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	16982696	RGD
involved in positive regulation of cell growth	IDA IDA: Inferred from direct assay	15795328	RGD
involved in positive regulation of dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	16049181	RGD
acts upstream of or within positive regulation of sodium ion transport	IMP IMP: Inferred from mutant phenotype	17715136	RGD
acts upstream of or within regulation of protein localization	IMP IMP: Inferred from mutant phenotype	17715136	RGD
involved in visual learning	IMP IMP: Inferred from mutant phenotype	14656333	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	10066787	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sgk1 Protein Structure

STKc_SGK

0
100
200
300
400
525 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase Sgk1

serine/threonine protein kinase SGK

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15192	GSK 650394	Inhibitor	99.76%	Unkown
HY-15193	EMD638683	Inhibitor	99.89%	Unkown
HY-18607	SGK1-IN-1	Inhibitor	99.67%	Unkown
HY-142686	SGK1-IN-3	Inhibitor	/	Unkown
HY-167832	PT109	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sgk1	NCBI	NCBI:6446

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