GTF2E2 - general transcription factor IIE subunit 2 Gene

Homo sapiens

Also known as FE; TTD6; TF2E2; TFIIE-B

Gene ID: 2961 | Gene type: protein coding

About GTF2E2

Cytogenetic location: 8p12 Genomic coordinates (GRCh38): 8:30,578,318-30,658,236 (from NCBI)

This gene has 5 transcripts (splice variants), 205 orthologues and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 12.1), lymph node (RPKM 9.3) and 25 other tissues.

Summary

The general transcription factor IIE (TFIIE) is part of the RNA polymerase II transcription initiation complex, recruiting TFIIH and being essential for promoter clearance by RNA polymerase II. TFIIE is a heterodimer (and sometimes heterotetramer) of alpha and beta subunits. The protein encoded by this gene represents the beta subunit of TFIIE. [provided by RefSeq, Jan 2017]

GTF2E2 Products(2)

mRNA	Protein	Name
NM_001348353.1	NP_001335282.1	transcription initiation factor IIE subunit beta isoform 2
NM_002095.6	NP_002086.1	transcription initiation factor IIE subunit beta isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II general transcription initiation factor activity	IDA IDA: Inferred from direct assay	27193682	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7926747	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	27193682	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of transcription factor TFIID complex	IDA IDA: Inferred from direct assay	27193682	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GTF2E2 Protein Structure

TFIIE_beta

0
100
200
291 a.a.

Protein Preferred Names

Protein Names

transcription initiation factor IIE subunit beta

TFIIE beta subunit

GTF2E2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GTF2E2	P29084	KAT5	Homo sapiens	Q92993	Validated Y2H	32296183
Intra	GTF2E2	P29084	GTF2E1	Homo sapiens	P29083	Anti Tag CoIP	33961781
Intra	GTF2E2	P29084	GTF2E1	Homo sapiens	P29083	EM	16547462
Intra	GTF2E2	P29084	GTF2E1	Homo sapiens	P29083	Y2H Prey Pooling	32296183
Intra	GTF2E2	P29084	GTF2E1	Homo sapiens	P29083	Crosslink	16547462
Intra	GTF2E2	P29084	GTF2E1	Homo sapiens	P29083	Y2H Array	32296183
Intra	GTF2E2	P29084	GTF2E1	Homo sapiens	P29083	Anti Tag CoIP	28514442
Intra	GTF2E2	P29084	EXOC8	Homo sapiens	Q8IYI6	Y2H Array	32296183
Intra	GTF2E2	P29084	EXOC8	Homo sapiens	Q8IYI6	Validated Y2H	32296183
Intra	GTF2E2	P29084	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	GTF2E2	P29084	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	GTF2E2	P29084	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Trichothiodystrophy 6, Nonphotosensitive

TTD6	Nonphotosensitive Trichothiodystrophy 6
Trichothiodystrophy 6, Non-Photosensitive

Trichothiodystrophy

Ttd	Amish Brittle Hair Syndrome
Bids Syndrome	Brittle Hair-Intellectual Impairment-Decreased Fertility-Short Stature Syndrome
Ibids	Pibids
Trichothiodystrophy Syndromes

Ichthyosis

Ichthyoses	Non-Syndromic Ichthyosis
Congenital Ichthyosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05895	GTF2E2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GTF2E2	VGNC	VGNC:41545
Mus musculus	GTF2E2	MGD	MGI:1915403
Rattus norvegicus	GTF2E2	RGD	RGD:1310134
Bos taurus	GTF2E2	VGNC	VGNC:29694
Felis catus	GTF2E2	VGNC	VGNC:67496
Macaca mulatta	GTF2E2	VGNC	VGNC:73308

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