Btg2 - BTG anti-proliferation factor 2 Gene

Rattus norvegicus

Also known as An; Agl; Pc3; an-1; Tis21

Gene ID: 29619 | Gene type: protein coding

About Btg2

Summary

Enables transcription corepressor activity. Involved in several processes, including negative regulation of neuron apoptotic process; response to electrical stimulus; and response to peptide hormone. Acts upstream of or within negative regulation of apoptotic process; negative regulation of transcription by RNA polymerase II; and neuron differentiation. Predicted to be active in cytoplasm and nucleus. Biomarker of acute necrotizing pancreatitis and brain ischemia. Orthologous to human BTG2 (BTG anti-proliferation factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Btg2 Products(1)

mRNA	Protein	Name
NM_017259.2	NP_058955.1	protein BTG2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11237868	RGD
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	20020054	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to phorbol 13-acetate 12-myristate	IEP IEP: Inferred from expression pattern	2005087	RGD
acts upstream of or within negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	12360398	RGD
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	12360398	RGD
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20020054	RGD
acts upstream of or within neuron differentiation	IDA IDA: Inferred from direct assay	12360398	RGD
involved in neuron differentiation	IEP IEP: Inferred from expression pattern	23000394	RGD
involved in response to electrical stimulus	IEP IEP: Inferred from expression pattern	8879470	RGD
involved in response to mechanical stimulus	IEP IEP: Inferred from expression pattern	15519684	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	8263025	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein BTG2

B-cell translocation gene 2, anti-proliferative	BTG family, member 2
Early induced gene B-cell translocation gene 2	NGF-inducible anti-proliferative protein PC3
NGF-inducible anti-proliferative putative secreted protein	cell surface alloantigen

Btg2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Btg2	P27049	Pick1	Rattus norvegicus	Q9EP80	Pull Down	11237868

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01663	BTG2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Btg2	NCBI	NCBI:7832

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