S1pr1 - sphingosine-1-phosphate receptor 1 Gene

Rattus norvegicus

Also known as Edg1

Gene ID: 29733 | Gene type: protein coding

About S1pr1

Primary_assembly 2: 203,621,587-203,629,681 reverse strand.mRatBN7.2:CM026975.1

This gene has 1 transcript (splice variant), 199 orthologues, 18 paralogues and is associated with 11 phenotypes. Biased expression in Lung (RPKM 299.1), Spleen (RPKM 279.3) and 8 other tissues.

Summary

Enables G protein-coupled receptor activity and sphingolipid binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; negative regulation of stress fiber assembly; and positive regulation of GTPase activity. Predicted to be located in external side of plasma membrane and nucleoplasm. Predicted to be intrinsic component of plasma membrane. Predicted to be active in cytoplasm and plasma membrane. Used to study hypertension. Orthologous to human S1PR1 (sphingosine-1-phosphate receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

S1pr1 Products(1)

mRNA	Protein	Name
NM_017301.2	NP_058997.1	sphingosine 1-phosphate receptor 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled receptor activity	IMP IMP: Inferred from mutant phenotype	11557736	RGD
enables sphingolipid binding	IDA IDA: Inferred from direct assay	9765227	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	11557736	RGD
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	9765227	RGD
involved in endothelial cell differentiation	IEP IEP: Inferred from expression pattern	7959012	RGD
involved in negative regulation of stress fiber assembly	IDA IDA: Inferred from direct assay	11094076	RGD
involved in neuron differentiation	IEP IEP: Inferred from expression pattern	7959012	RGD
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	9765227	RGD
involved in positive regulation of GTPase activity	IDA IDA: Inferred from direct assay	14711826	RGD
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	11557736	RGD
involved in positive regulation of positive chemotaxis	IDA IDA: Inferred from direct assay	11094076	RGD
involved in positive regulation of smooth muscle cell proliferation	IDA IDA: Inferred from direct assay	11557736	RGD
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	14711826	RGD
involved in transmission of nerve impulse	IEP IEP: Inferred from expression pattern	7959012	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

S1pr1 Protein Structure

7tmA_S1PR1_Edg1

0
100
200
300
383 a.a.

Protein Preferred Names

Protein Names

sphingosine 1-phosphate receptor 1

EDG1 (Edg1)	S1P receptor 1
S1P receptor Edg-1	S1P1
endothelial differentiation G-protein coupled receptor 1	endothelial differentiation sphingolipid G-protein-coupled receptor 1
sphingosine 1-phosphate receptor Edg-1

Related Agents

Approval

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12355	Siponimod	Agonist	99.95%	Yes
HY-12288	Ozanimod	Agonist	99.88%	Yes
HY-10569	Ponesimod	Agonist	99.81%	Yes
HY-12288A	Ozanimod hydrochloride	Modulator	99.19%	Yes
HY-12355A	Siponimod hemifumarate	Agonist	/	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-17606	Cenerimod	Agonist	99.43%	Phase 3
HY-115831	SAR247799	Agonist	97.21%	Phase 1

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W008947	SEW2871	Agonist	99.77%	Unkown
HY-136578	RP101988	Agonist	98.92%	Unkown
HY-111253	CYM-5478	Agonist	99.90%	Unkown
HY-147660	IMMH001	Agonist	98.10%	Unkown
HY-113934	L-threo Lysosphingomyelin (d18:1)	Agonist	≥98.0%	Unkown
HY-136576	RP101075	Agonist	/	Unkown
HY-158417	KSI-6666	Antagonist	/	Unkown
HY-119245	Udifitimod	Modulator	/	Unkown
HY-136577	RP101442	Agonist	/	Unkown
HY-108492	TC-SP 14	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	S1pr1	NCBI	NCBI:1901

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