2. Gene
  3. CYP2S1 - cytochrome P450 family 2 subfamily S member 1 Gene

CYP2S1 - cytochrome P450 family 2 subfamily S member 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as CYPIIS1

Gene ID: 29785 | Gene type: protein coding

About CYP2S1

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:41,193,219-41,207,539 (from NCBI)

This gene has 6 transcripts (splice variants), 90 orthologues and 15 paralogues. Biased expression in stomach (RPKM 58.7), duodenum (RPKM 46.6) and 7 other tissues.

Summary

This gene encodes a member of the Cytochrome P450 superfamily of Enzymes. The Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of Cholesterol, Steroids and Other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. [provided by RefSeq, Jul 2008]

CYP2S1 Products(1)

mRNA Protein Name
NM_030622.8 NP_085125.1 cytochrome P450 2S1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables hydro-lyase activity IDA
IDA: Inferred from direct assay
21068195 GOA
enables monooxygenase activity IDA
IDA: Inferred from direct assay
12711469 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables thromboxane-A synthase activity IDA
IDA: Inferred from direct assay
21068195 GOA
Biological Process GO Annotation Evidence Reference Source
involved in icosanoid metabolic process IDA
IDA: Inferred from direct assay
21068195 GOA
involved in prostaglandin metabolic process IDA
IDA: Inferred from direct assay
21068195 GOA
involved in retinoic acid metabolic process IDA
IDA: Inferred from direct assay
12711469 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CYP2S1 Protein Structure

p450

p450: Cytochrome P450 (33 - 490)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 504 a.a.
Protein Preferred Names Protein Names

cytochrome P450 2S1

cytochrome P450, family 2, subfamily S, polypeptide 1

CYP2S1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CYP2S1 Q96SQ9 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
CYP2S1 Q96SQ9 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
CYP2S1 Q96SQ9 ADAMTSL4 Homo sapiens Q6UY14-3
Validated Y2H
25416956
Intra
CYP2S1 Q96SQ9 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03467 CYP2S1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CYP2S1 MGD MGI:1921384
Macaca mulatta CYP2S1 VGNC VGNC:103641
Bos taurus CYP2S1 VGNC VGNC:110261
Rattus norvegicus CYP2S1 RGD RGD:1306078
Felis catus CYP2S1 VGNC VGNC:103487
Canis familiaris CYP2S1 VGNC VGNC:50356