ZDHHC1 - zinc finger DHHC-type containing 1 Gene

Homo sapiens

Also known as DHHC-1; ZNF377; C16orf1; HSU90653

Gene ID: 29800 | Gene type: protein coding

About ZDHHC1

This gene has 6 transcripts (splice variants), 215 orthologues and 17 paralogues. Ubiquitous expression in ovary (RPKM 6.2), testis (RPKM 6.1) and 24 other tissues.

Summary

Enables palmitoyltransferase activity. Involved in Antiviral innate immune response; positive regulation of defense response to virus by host; and protein palmitoylation. Located in Golgi apparatus and endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]

ZDHHC1 Products(2)

mRNA	Protein	Name
NM_001323627.2	NP_001310556.1	palmitoyltransferase ZDHHC1 isoform 2
NM_013304.3	NP_037436.1	palmitoyltransferase ZDHHC1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables palmitoyltransferase activity	IDA IDA: Inferred from direct assay	23034182	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25299331	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in antiviral innate immune response	IMP IMP: Inferred from mutant phenotype	25299331	GOA
involved in positive regulation of defense response to virus by host	IMP IMP: Inferred from mutant phenotype	25299331	GOA
involved in protein palmitoylation	IDA IDA: Inferred from direct assay	23034182	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	25299331	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	16647879	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	25299331	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZDHHC1 Protein Structure

DHHC

0
100
200
300
400
485 a.a.

Protein Preferred Names

Protein Names

palmitoyltransferase ZDHHC1

DHHC domain-containing cysteine-rich protein 1

ZDHHC1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZDHHC1	Q8WTX9	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	ZDHHC1	Q8WTX9	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	ZDHHC1	Q8WTX9	KRTAP12-2	Homo sapiens	P59991	Y2H Prey Pooling	32296183
Intra	ZDHHC1	Q8WTX9	KRTAP12-2	Homo sapiens	P59991	Y2H Array	32296183
Intra	ZDHHC1	Q8WTX9	KRT83	Homo sapiens	P78385	Y2H Array	32296183
Intra	ZDHHC1	Q8WTX9	KRT83	Homo sapiens	P78385	Y2H Prey Pooling	32296183
Intra	ZDHHC1	Q8WTX9	KRTAP9-2	Homo sapiens	Q9BYQ4	Validated Y2H	32296183
Intra	ZDHHC1	Q8WTX9	KRTAP9-2	Homo sapiens	Q9BYQ4	Y2H Array	32296183
Intra	ZDHHC1	Q8WTX9	KRTAP9-2	Homo sapiens	Q9BYQ4	Y2H Prey Pooling	32296183
Intra	ZDHHC1	Q8WTX9	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	ZDHHC1	Q8WTX9	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	ZDHHC1	Q8WTX9	GOPC	Homo sapiens	Q9HD26-2	Y2H Prey Pooling	32296183
Intra	ZDHHC1	Q8WTX9	GOPC	Homo sapiens	Q9HD26-2	Validated Y2H	32296183
Intra	ZDHHC1	Q8WTX9	GOPC	Homo sapiens	Q9HD26-2	Y2H Array	32296183
Intra	ZDHHC1	Q8WTX9	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Prey Pooling	32296183
Intra	ZDHHC1	Q8WTX9	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Array	32296183
Intra	ZDHHC1	Q8WTX9	KRTAP12-3	Homo sapiens	P60328	Y2H Prey Pooling	32296183
Intra	ZDHHC1	Q8WTX9	KRTAP12-3	Homo sapiens	P60328	Y2H Array	32296183
Intra	ZDHHC1	Q8WTX9	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	ZDHHC1	Q8WTX9	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
Intra	ZDHHC1	Q8WTX9	KRTAP17-1	Homo sapiens	Q9BYP8	Y2H Prey Pooling	32296183
Intra	ZDHHC1	Q8WTX9	KRTAP17-1	Homo sapiens	Q9BYP8	Validated Y2H	32296183
Intra	ZDHHC1	Q8WTX9	KRTAP17-1	Homo sapiens	Q9BYP8	Y2H Array	32296183
Intra	ZDHHC1	Q8WTX9	KRTAP2-4	Homo sapiens	Q9BYR9	Y2H Array	32296183
Intra	ZDHHC1	Q8WTX9	KRTAP2-4	Homo sapiens	Q9BYR9	Y2H Prey Pooling	32296183
Intra	ZDHHC1	Q8WTX9	KRTAP2-4	Homo sapiens	Q9BYR9	Validated Y2H	32296183
Intra	ZDHHC1	Q8WTX9	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	ZDHHC1	Q8WTX9	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	ZDHHC1	Q8WTX9	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	ZDHHC1	Q8WTX9	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	ZDHHC1	Q8WTX9	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	32296183
Intra	ZDHHC1	Q8WTX9	MDFI	Homo sapiens	Q99750	Validated Y2H	32296183
Intra	ZDHHC1	Q8WTX9	MDFI	Homo sapiens	Q99750	Y2H Array	32296183
Intra	ZDHHC1	Q8WTX9	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	ZDHHC1	Q8WTX9	KRT31	Homo sapiens	Q15323	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Immunodeficiency 10

Immune Dysfunction With T-Cell Inactivation Due To Calcium Entry Defect 2	Combined Immunodeficiency Due To Stim1 Deficiency
IMD10	Stim1 Deficiency
Cid Due To Stim1 Deficiency	Immune Dysfunction, With T-Cell Inactivation Due To Calcium Entry Defect 2
Immunodeficiency, Type 10

T Cell And Nk Cell Immunodeficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16011	ZDHHC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ZDHHC1	MGD	MGI:1918046
Canis familiaris	ZDHHC1	VGNC	VGNC:48577
Macaca mulatta	ZDHHC1	VGNC	VGNC:79102
Bos taurus	ZDHHC1	VGNC	VGNC:37126
Rattus norvegicus	ZDHHC1	RGD	RGD:1589775
Felis catus	ZDHHC1	VGNC	VGNC:67200

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