SNX12 - sorting nexin 12 Gene

Homo sapiens

Gene ID: 29934 | Gene type: protein coding

About SNX12

Cytogenetic location: Xq13.1 Genomic coordinates (GRCh38): X:71,059,247-71,073,426 (from NCBI)

This gene has 7 transcripts (splice variants), 215 orthologues and 15 paralogues. Ubiquitous expression in kidney (RPKM 19.5), thyroid (RPKM 17.8) and 25 other tissues.

Summary

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. A similar protein in mouse may be involved in regulating the neurite outgrowth. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

SNX12 Products(5)

mRNA	Protein	Name
NM_001256185.2	NP_001243114.1	sorting nexin-12 isoform 1
NM_001256186.2	NP_001243115.1	sorting nexin-12 isoform 2
NM_001256187.2	NP_001243116.1	sorting nexin-12 isoform 3
NM_001256188.2	NP_001243117.1	sorting nexin-12 isoform 4
NM_013346.4	NP_037478.2	sorting nexin-12 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	22709416	GOA
enables phosphatidylinositol binding	IDA IDA: Inferred from direct assay	22719997	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17474147	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of early endosome to late endosome transport	IDA IDA: Inferred from direct assay	22719997	GOA
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	22709416	GOA
involved in negative regulation of protein catabolic process	IDA IDA: Inferred from direct assay	22719997	GOA
involved in negative regulation of protein processing	IDA IDA: Inferred from direct assay	22709416	GOA
involved in negative regulation of protein transport	IDA IDA: Inferred from direct assay	22719997	GOA
involved in regulation of endocytosis	IMP IMP: Inferred from mutant phenotype	22709416	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in early endosome	IDA IDA: Inferred from direct assay	22709416	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNX12 Protein Structure

0
100
162 a.a.

Protein Preferred Names

Protein Names

sorting nexin-12

SNX12 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SNX12	Q9UMY4	KLKB1	Homo sapiens	P03952	Y2H Array	32814053
Intra	SNX12	Q9UMY4	KLKB1	Homo sapiens	P03952	Validated Y2H	32814053
Intra	SNX12	Q9UMY4	KLKB1	Homo sapiens	P03952	Y2H Pooling	32814053
Intra	SNX12	Q9UMY4	CCT2	Homo sapiens	P78371	Validated Y2H	32814053
Intra	SNX12	Q9UMY4	CCT2	Homo sapiens	P78371	Y2H Array	32814053
Intra	SNX12	Q9UMY4	CCT2	Homo sapiens	P78371	Y2H Pooling	32814053
Intra	SNX12	Q9UMY4	NCK1	Homo sapiens	P16333	Peptide Array	17474147
Intra	SNX12	Q9UMY4	ARL6IP1	Homo sapiens	Q15041	Y2H Array	25416956
Intra	SNX12	Q9UMY4	LPL	Homo sapiens	P06858	Y2H Array	32814053
Intra	SNX12	Q9UMY4	LPL	Homo sapiens	P06858	Validated Y2H	32814053
Intra	SNX12	Q9UMY4	LPL	Homo sapiens	P06858	Y2H Pooling	32814053
Intra	SNX12	Q9UMY4	PACSIN1	Homo sapiens	Q9BY11	Validated Y2H	32814053
Intra	SNX12	Q9UMY4	PACSIN1	Homo sapiens	Q9BY11	Y2H Array	32814053
Intra	SNX12	Q9UMY4	PACSIN1	Homo sapiens	Q9BY11	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13525	SNX12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SNX12	RGD	RGD:1565585
Felis catus	SNX12	VGNC	VGNC:65543
Bos taurus	SNX12	VGNC	VGNC:35093
Mus musculus	SNX12	MGD	MGI:1919331
Macaca mulatta	SNX12	VGNC	VGNC:77707

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