SNX12 - sorting nexin 12 Gene

Homo sapiens

Gene ID: 29934 | Gene type: protein coding

About SNX12

Cytogenetic location: Xq13.1 Genomic coordinates (GRCh38): X:71,059,247-71,073,426 (from NCBI)

This gene has 7 transcripts (splice variants), 215 orthologues and 15 paralogues. Ubiquitous expression in kidney (RPKM 19.5), thyroid (RPKM 17.8) and 25 other tissues.

Summary

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. A similar protein in mouse may be involved in regulating the neurite outgrowth. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

SNX12 Products(5)

mRNA	Protein	Name
NM_001256185.2	NP_001243114.1	sorting nexin-12 isoform 1
NM_001256186.2	NP_001243115.1	sorting nexin-12 isoform 2
NM_001256187.2	NP_001243116.1	sorting nexin-12 isoform 3
NM_001256188.2	NP_001243117.1	sorting nexin-12 isoform 4
NM_013346.4	NP_037478.2	sorting nexin-12 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	22709416	GOA
enables phosphatidylinositol binding	IDA IDA: Inferred from direct assay	22719997	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17474147	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of early endosome to late endosome transport	IDA IDA: Inferred from direct assay	22719997	GOA
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	22709416	GOA
involved in negative regulation of protein catabolic process	IDA IDA: Inferred from direct assay	22719997	GOA
involved in negative regulation of protein processing	IDA IDA: Inferred from direct assay	22709416	GOA
involved in negative regulation of protein transport	IDA IDA: Inferred from direct assay	22719997	GOA
involved in regulation of endocytosis	IMP IMP: Inferred from mutant phenotype	22709416	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in early endosome	IDA IDA: Inferred from direct assay	22709416	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNX12 Protein Structure

0
100
162 a.a.

Protein Preferred Names

Protein Names

sorting nexin-12

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13525	SNX12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SNX12	RGD	RGD:1565585
Felis catus	SNX12	VGNC	VGNC:65543
Bos taurus	SNX12	VGNC	VGNC:35093
Mus musculus	SNX12	MGD	MGI:1919331
Macaca mulatta	SNX12	VGNC	VGNC:77707

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