PNMA3 - PNMA family member 3 Gene

Homo sapiens

Also known as MA3; MA5

Gene ID: 29944 | Gene type: protein coding

About PNMA3

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:153,056,470-153,060,462 (from NCBI)

This gene has 3 transcripts (splice variants), 560 orthologues and 13 paralogues. Biased expression in brain (RPKM 9.4), testis (RPKM 8.8) and 7 other tissues.

Summary

The protein encoded by this gene belongs to the paraneoplastic antigen MA (PNMA) family, which shares homology with retroviral Gag proteins. The PNMA antigens are highly expressed in the brain and also in a range of tumors associated with serious neurological phenotypes. PMID:16407312 reports the presence of a functional -1 ribosomal frameshift signal (consisting of a heptanucleotide shift motif followed 3' by a pseudoknot structure) in this gene, however, the frame-shifted product has not been characterized. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

PNMA3 Products(2)

mRNA	Protein	Name
NM_001282535.2	NP_001269464.1	paraneoplastic antigen Ma3 isoform 2
NM_013364.6	NP_037496.4	paraneoplastic antigen Ma3 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PNMA3 Protein Structure

PNMA

0
100
200
300
400
463 a.a.

Protein Preferred Names

Protein Names

paraneoplastic antigen Ma3

paraneoplastic Ma antigen 3

PNMA3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PNMA3	Q9UL41	RPH3AL	Homo sapiens	Q9UNE2	Validated Y2H	32296183
Intra	PNMA3	Q9UL41	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	PNMA3	Q9UL41	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Alzheimer Disease 11

Ad11	Alzheimer'S Disease 11
Alzheimer Disease, Familial, 11	Alzheimer Disease-11
Alzheimer'S Disease 11, Late Onset

Melon Allergy

Cucumis Melo Fruit Allergy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10784	PNMA3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PNMA3	VGNC	VGNC:64262
Rattus norvegicus	PNMA3	RGD	RGD:1563752
Mus musculus	PNMA3	MGD	MGI:2180565
Macaca mulatta	PNMA3	VGNC	VGNC:76063

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